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A Clinician's Guide to Systemic Effects of Periodontal Diseases pp 107–115Cite as

Periodontal Infections and Rheumatoid Arthritis

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Abstract

Rheumatoid arthritis (RA) is a chronic, destructive, autoimmune disorder characterized by autoantibody production and predilection for the joints that can lead to accelerated morbidity, mortality, and disability [1]. Current understanding of RA pathogenesis posits that a combination of host predisposition and risk factors is most likely required for the initiation and sustainability of the inflammatory process. However, the exact combination of factors and the precise timing for clinical manifestations are still insufficiently understood [2]. Mounting evidence suggests that environmental risk factors such as commensal and infectious microbiota may contribute to RA in patients with genetic susceptibility [3]. New findings suggest that germ-free mice, lacking all microbiota, are resistant to development of spontaneous autoimmune arthritis [4]. Intriguingly, recent evidence suggests that, in the right genetic background [5], the presence of certain predisposing factors (i.e., periodontitis (PD) and smoking) [6–9] along with serological markers (i.e., autoantibodies and proinflammatory cytokines) may predict the emergence of RA [10].

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Author information

Authors and Affiliations

  1. Department of Cariology and Comprehensive Care, New York University College of Dentistry, New York, NY, USA

    Walter A. Bretz DDS, PhD

  2. Division of Rheumatology, New York University School of Medicine, New York, NY, USA

    Jose U. Scher MD

  3. New York University Langone Hospital for Joint Diseases, New York, NY, USA

    Jose U. Scher MD

  4. Department of Medicine, New York University School of Medicine, New York, NY, USA

    Steven B. Abramson MD

Authors
  1. Walter A. Bretz DDS, PhD
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  2. Jose U. Scher MD
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  3. Steven B. Abramson MD
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Corresponding author

Correspondence to Walter A. Bretz DDS, PhD .

Editor information

Editors and Affiliations

  1. Basic Sciences and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA

    Ronald G. Craig

  2. New York University College of Dent, New York, New York, USA

    Angela R. Kamer

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Bretz, W.A., Scher, J.U., Abramson, S.B. (2016). Periodontal Infections and Rheumatoid Arthritis. In: Craig, R., Kamer, A. (eds) A Clinician's Guide to Systemic Effects of Periodontal Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49699-2_9

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  • DOI: https://doi.org/10.1007/978-3-662-49699-2_9

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  • Online ISBN: 978-3-662-49699-2

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