Abstract
Cardiovascular diseases (CVD) are the world’s leading cause of mortality, claiming over 17 million lives per year [1]. In the United States alone, over 800,000 individuals died from CVD in 2013, or about one-third of all deaths that year, making CVD the leading cause of death in the nation [2, 3]. Coronary heart disease accounts for just under half of CVD deaths, and with cerebrovascular disease and peripheral vascular disease, comprises the atherosclerotic vascular diseases (ASVD). The annual incidence of global ASVD mortality is expected to rise to an estimated 23.6 million deaths by the year 2030. As a comparison, ASVD annually accounts for more deaths in the United States than all forms of cancer combined [2]. However, progress is being made to moderate the high rate of ASVD mortality through risk reduction strategies and improvements in therapy.
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References
Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, Naghavi M, Mensah GA, Murray CJ. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372:1333–41.
Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha M, Cushman M, de Ferranti S, Despres J-P, Fullerton J, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Moller ER, Moy CS, Munter P, Mussdfolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pankey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virami SS, Willey JZ, Woo D, Yeh RW, Turner MB, on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics – 2015. Update from the American Heart Association. Circulation. 2015;131:434–41.
GBD 2013 Morality and Causes of Death Collaborators. Global, regional and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–71.
Mitchell RN. Blood vessels. In: Kumar V, Abbas AK, Aster JC, editors. Robbin and cotran pathologic basis of disease. Philadelphia: Elsevier/Saunders; 2015. p. 483–522.
Ridker PM, Cannon CP, Morrw D, Rifai N, Rose LM, McCabe CH, Pfeffer MA, Braunwald E. C-reactive protein levels and outcomes after statin therapy. N Engl J Med. 2005;352:20–8.
Ross R. Atherosclerosis – an inflammatory disease. N Engl J Med. 1999;340:115.
Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32:2045–51.
Grebe A, Latz E. Cholesterol crystals and inflammation. Curr Rheumatol Rep. 2013;15:313–20.
Witztum JL, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol. 2014;9:73–102.
Finn AV, Kolodgie FD, Virmani R. Correlation between carotid intimal/medial thickness and atherosclerosis. A point of view from pathology. Arterioscler Thromb Vasc Biol. 2010;30:177–81.
Finn AV, Nakano M, Narula J, Koldgie FD, Virmani R. Concept of vulnerable/unstable plaque. Arterioscler Thromb Vasc Biol. 2010;30:1282–92.
Ridker PM. C-reactive protein : eighty years from discovery to emergence as a major risk marker for cardiovascular disease. Clin Chem. 2009;55.
Mattila KJ, Nieminen MS. Association between dental health acute myocardial infarction. BMJ. 1989;298:779–81.
Syrjanen J, Peltola J. Dental infections in association with cerebral infarction in young and middle-aged me. J Intern Med. 1989;225:179–84.
Bahekar AA, Singh S, Saha S, Molnar J, Arora R. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J. 2007;154:830–7.
Friedewald VE, Kornman KS, Beck JD, Genco R, Goldfine A, Libby P, Offenbacher S, Ridker PM, Van Dyke TE, Roberts WC. The american journal of cardiology and journal of periodontology editors’ consensus: periodontitis and atherosclerotic cardiovascular disease. Am J Cardiol. 2009;104:59–68.
Humphrey LL, Fu R, Buckley DI, Freeman M, Helfand MJ. Periodontal disease and coronary heart disease incidence: a systematic review and meta-analysis. J Gen Intern Med. 2008;23:2079–86.
Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005;43:5721–32.
Haraszthy Zambon JJ, Trevisan M, Zeid M, Genco RJ. Identification of periodontal pathogens in atheromatous plaques. J Periodontol. 2000;71:1554–60.
Lockhart PB, Bolger AF, Papapanou PN, Osinbowale O, Trevisan M, Levison ME, Taubert KA, Newburger JW, Gonik HL, Gewitz MH, Wilson WR, Smith SC, Baddour LM. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association? A scientific statement from the American Heart Association. Circulation. 2012;125:2520–44.
Andrews R, Berger JS, Brown DL. Effects of antibiotic therapy on outcomes of patients with coronary artery disease: a meta-analysis of randomized controlled trials. JAMA. 2005;293:2641–7.
Leishman SJ, Ford PJ, Do HL, Palmer JE, Heng NC, West MJ, Seymour GJ, Cullinan MP. Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. J Clin Periodontol. 2012;39:923–30.
Cullinan MP, Seymour GJ. Periodontal disease and systemic illness: will the evidence ever be enough? Periodontol 2000. 2013;62:271–86.
D’Aiuto F, Orlandi M, Gunsolley JC. Evidence the periodontal treatment improves biomarkers and CVD outcomes. J Clin Periodontol. 2013;40:S85–105.
Teeuw WJ, Solt DE, Susanto H, Gerdes VE, Abbas F, D’Aiuto F, Kastelein JJP, Loos BG. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J Clin Periodontol. 2014;41:70–9.
Orlandi M, Suvan J, Petrie A, Donos N, Masi S, Hingorani A, Deanfield J, D’Aiuto F. Association between periodontal disease and its treatment: a systematic review and meta-analysis. Atherosclerosis. 2014;236:39–46.
Tonetti MS, D’Auito F, Nibati L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J. Treatment of periodontitis and endothelial function. N Engl J Med. 2007;356:911–20.
Piconi S, Trabattoni D, Luraghi C, Perilli E, Borelli M, Pacei M, Rizzardini G, Lattudada A, Bray DH, Catalano M, Sparaco A, Clerici M. Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-medial thickness. FASEB J. 2009;23:1196–204.
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Reynolds, H.R., Craig, R.G. (2016). Atherosclerotic Vascular Disease and Periodontal Disease. In: Craig, R., Kamer, A. (eds) A Clinician's Guide to Systemic Effects of Periodontal Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49699-2_4
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DOI: https://doi.org/10.1007/978-3-662-49699-2_4
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