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Major and Minor Salivary Glands

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Pathology of the Head and Neck

Abstract

The chapter explores the colourful world of salivary gland tumours with extensive illustrations and a very detailed index.

It covers the full range of salivary disease including normal anatomy and histology, non-neoplastic diseases, benign and malignant primary salivary gland tumours, lymphoid disorders and metastases.

Each entity includes aetiology, definition, pathogenesis, microscopy with immunohistochemistry, special staining, molecular genetics and differential diagnosis.

Chapter 5 is recommended for use in academic settings and also in routine practice as it is based on the clinical work of all the authors, all of whom have extensive experience.

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References

  1. Martinez-Madrigal F, Micheau C. Histology of the major salivary glands. Am J Surg Pathol. 1989;13(10):879–99.

    Article  CAS  PubMed  Google Scholar 

  2. Ihrler S, et al. A morphogenetic concept of salivary duct regeneration and metaplasia. Virchows Arch. 2002;440(5):519–26.

    Article  PubMed  Google Scholar 

  3. Ihrler S, et al. Regeneration in chronic sialadenitis: an analysis of proliferation and apoptosis based on double immunohistochemical labelling. Virchows Arch. 2004;444(4):356–61.

    Article  PubMed  Google Scholar 

  4. Prasad AR, et al. The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. Arch Pathol Lab Med. 1999;123(9):801–6.

    CAS  PubMed  Google Scholar 

  5. Foschini MP, et al. Differential expression of myoepithelial markers in salivary, sweat and mammary glands. Int J Surg Pathol. 2000;8(1):29–37.

    Article  PubMed  Google Scholar 

  6. Jones H, Moshtael F, Simpson RH. Immunoreactivity of alpha smooth muscle actin in salivary gland tumors: a comparison with S100 protein. J Clin Pathol. 1992;45(10):938–40.

    Google Scholar 

  7. Batsakis JG, el-Naggar AK. Sebaceous lesions of salivary glands and oral cavity. Ann Otol Rhinol Laryngol. 1990;99(5 Pt 1):416–8.

    Article  CAS  PubMed  Google Scholar 

  8. Auclair PL. Tumor-associated lymphoid proliferation in the parotid gland. A potential diagnostic pitfall. Oral Surg Oral Med Oral Pathol. 1994;77(1):19–26.

    Article  CAS  PubMed  Google Scholar 

  9. Harris NL. Lymphoid proliferations of the salivary glands. Am J Clin Pathol. 1999;111(1 Suppl 1):S94–103.

    CAS  PubMed  Google Scholar 

  10. Ihrler S, et al. Pattern recognition in the differential diagnosis of salivary lymphoepithelial lesions. Pathologe. 2009;30(6):432–41.

    Article  CAS  PubMed  Google Scholar 

  11. Seifert G. Primary salivary gland tumors in lymph nodes of the parotid gland. Report of 3 cases and review of the literature. Pathologe. 1997;18(2):141–6.

    Article  CAS  PubMed  Google Scholar 

  12. Harrison J. Histology and pathology of sialolithiasis. In: Surgical and medical management. New York: Thieme; 2006. p. 71–8.

    Google Scholar 

  13. Harrison JD. Causes, natural history, and incidence of salivary stones and obstructions. Otolaryngol Clin North Am. 2009;42(6):927–47. Table of Contents.

    Article  PubMed  Google Scholar 

  14. Werning J. Infectious and systemic diseases. In: Auclair P, Ellis GL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: Saunders; 1991.

    Google Scholar 

  15. Ihrler S, et al. HIV-related parotid lymphoepithelial cysts. Immunohistochemistry and 3-D reconstruction of surgical and autopsy material with special reference to formal pathogenesis. Virchows Arch. 1996;429(2–3):139–47.

    CAS  PubMed  Google Scholar 

  16. Jeffers L, Webster-Cyriaque JY. Viruses and salivary gland disease (SGD): lessons from HIV SGD. Adv Dent Res. 2011;23(1):79–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Geyer JT, et al. Chronic sclerosing sialadenitis (Kuttner tumor) is an IgG4-associated disease. Am J Surg Pathol. 2010;34(2):202–10.

    Article  PubMed  Google Scholar 

  18. Strehl JD, Hartmann A, Agaimy A. Numerous IgG4-positive plasma cells are ubiquitous in diverse localised non-specific chronic inflammatory conditions and need to be distinguished from IgG4-related systemic disorders. J Clin Pathol. 2011;64(3):237–43.

    Article  PubMed  Google Scholar 

  19. Harrison JD, Rodriguez-Justo M. Commentary on IgG4-related sialadenitis: Mikulicz’s disease, Kuttner’s tumor, and eponymy. Histopathology. 2011;58(7):1164–6.

    Google Scholar 

  20. Harrison JD, Rodriguez-Justo M. IgG4-related sialadenitis is rare: histopathological investigation of 129 cases of chronic submandibular sialadenitis. Histopathology. 2013;63(1):96–102.

    Article  PubMed  Google Scholar 

  21. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7(1):19–73.

    CAS  PubMed  Google Scholar 

  22. Herold J, Nicholson AG. Fine needle aspiration cytology in the diagnosis of amyloid in the submandibular gland. Br J Oral Maxillofac Surg. 1992;30(6):393–4.

    Article  CAS  PubMed  Google Scholar 

  23. Brannon RB, Fowler CB, Hartman KS. Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature. Oral Surg Oral Med Oral Pathol. 1991;72(3):317–25.

    Article  CAS  PubMed  Google Scholar 

  24. Batsakis JG, Manning JT. Necrotizing sialometaplasia of major salivary glands. J Laryngol Otol. 1987;101(9):962–6.

    Article  CAS  PubMed  Google Scholar 

  25. Ihrler S, et al. Pathogenesis of sialadenosis: possible role of functionally deficient myoepithelial cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):218–23.

    Article  PubMed  Google Scholar 

  26. Buchner A, et al. Adenomatoid hyperplasia of minor salivary glands. Oral Surg Oral Med Oral Pathol. 1991;71(5):583–7.

    Article  CAS  PubMed  Google Scholar 

  27. Di Palma S. Epithelial-myoepithelial carcinoma with co-existing multifocal intercalated duct hyperplasia of the parotid gland. Histopathology. 1994;25(5):494–6.

    Article  PubMed  Google Scholar 

  28. Chetty R. Intercalated duct hyperplasia: possible relationship to epithelial-myoepithelial carcinoma and hybrid tumors of salivary gland. Histopathology. 2000;37(3):260–3.

    Google Scholar 

  29. Weinreb I, et al. Intercalated duct lesions of salivary gland: a morphologic spectrum from hyperplasia to adenoma. Am J Surg Pathol. 2009;33(9):1322–9.

    Article  PubMed  Google Scholar 

  30. Konings AW, Coppes RP, Vissink A. On the mechanism of salivary gland radiosensitivity. Int J Radiat Oncol Biol Phys. 2005;62(4):1187–94.

    Article  CAS  PubMed  Google Scholar 

  31. Chan JKC, Tang S, Tsang WYW, Lee KC, Batsakis JG. Histologic changes induced by fine-needle aspiration. Adv Anat Pathol. 1996;3:71–90.

    Article  Google Scholar 

  32. Eveson JW, Cawson RA. Infarcted (‘infected’) adenolymphomas. A clinicopathological study of 20 cases. Clin Otolaryngol Allied Sci. 1989;14(3):205–10.

    Article  CAS  PubMed  Google Scholar 

  33. Li S, et al. Worrisome histologic alterations following fine-needle aspiration of benign parotid lesions. Arch Pathol Lab Med. 2000;124(1):87–91.

    CAS  PubMed  Google Scholar 

  34. Di Palma S, et al. Metaplastic (infarcted) Warthin’s tumor of the parotid gland: a possible consequence of fine needle aspiration biopsy. Histopathology. 1999;35(5):432–8.

    Google Scholar 

  35. Shintaku M, Honda T. Identification of oncocytic lesions of salivary glands by anti-mitochondrial immunohistochemistry. Histopathology. 1997;31(5):408–11.

    Article  CAS  PubMed  Google Scholar 

  36. Mukunyadzi P, et al. Tissue effects of salivary gland fine-needle aspiration. Does this procedure preclude accurate histologic diagnosis? Am J Clin Pathol. 2000;114(5):741–5.

    Article  CAS  PubMed  Google Scholar 

  37. Palmer TJ, et al. Oncocytic adenomas and oncocytic hyperplasia of salivary glands: a clinicopathological study of 26 cases. Histopathology. 1990;16(5):487–93.

    Article  CAS  PubMed  Google Scholar 

  38. Pereira L, et al. Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors. BMC Cancer. 2012;12:53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Brandwein MS, Huvos AG. Oncocytic tumors of major salivary glands. A study of 68 cases with follow-up of 44 patients. Am J Surg Pathol. 1991;15(6):514–28.

    Article  CAS  PubMed  Google Scholar 

  40. Sato S, et al. Multifocal nodular oncocytic hyperplasia of bilateral parotid glands: a case report with a histological variant of clear cells. Pathol Res Pract. 2011;207(7):452–5.

    Article  PubMed  Google Scholar 

  41. Kontaxis A, et al. Diffuse hyperplastic oncocytosis of the parotid gland. Laryngorhinootologie. 2004;83(3):185–8.

    Article  CAS  PubMed  Google Scholar 

  42. Seifert G. Tumor-like lesions of the salivary glands. The new WHO classification. Pathol Res Pract. 1992;188(7):836–46.

    Google Scholar 

  43. Seifert G, Thomsen S, Donath K. Bilateral dysgenetic polycystic parotid glands. Morphological analysis and differential diagnosis of a rare disease of the salivary glands. Virchows Arch A Pathol Anat Histol. 1981;390(3):273–88.

    Article  CAS  PubMed  Google Scholar 

  44. Smyth AG, Ward-Booth RP, High AS. Polycystic disease of the parotid glands: two familial cases. Br J Oral Maxillofac Surg. 1993;31(1):38–40.

    Article  CAS  PubMed  Google Scholar 

  45. Davis PB. Cystic fibrosis since 1938. Am J Respir Crit Care Med. 2006;173(5):475–82.

    Article  PubMed  Google Scholar 

  46. Villella VR, et al. Targeting the intracellular environment in cystic fibrosis: restoring autophagy as a novel strategy to circumvent the CFTR defect. Front Pharmacol. 2013;4:1.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Vinayachandran D, Sankarapandian S. Salivary duct cyst: histo-pathologic correlation. J Clin Imaging Sci. 2013;3 Suppl 1:3.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Ellis GL, Auclair P. Tumors of the salivary glands. In: Atlas of tumor pathology. Washington, DC: AFIP; 2008.

    Google Scholar 

  49. Jensen J. Idiopathic diseases. In: Auclair P, Ellis GL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: Saunders; 1991.

    Google Scholar 

  50. Elliott JN, Oertel YC. Lymphoepithelial cysts of the salivary glands. Histologic and cytologic features. Am J Clin Pathol. 1990;93(1):39–43.

    Article  CAS  PubMed  Google Scholar 

  51. Jaffe ES. Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Mod Pathol. 2002;15(3):255–63.

    Article  PubMed  Google Scholar 

  52. Smith BC, et al. Sclerosing polycystic adenosis of major salivary glands. A clinicopathologic analysis of nine cases. Am J Surg Pathol. 1996;20(2):161–70.

    Article  CAS  PubMed  Google Scholar 

  53. Skalova A, et al. Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol. 2006;30(8):939–44.

    Article  PubMed  Google Scholar 

  54. Skalova A, et al. Sclerosing polycystic adenosis of parotid gland with dysplasia and ductal carcinoma in situ. Report of three cases with immunohistochemical and ultrastructural examination. Virchows Arch. 2002;440(1):29–35.

    Article  CAS  PubMed  Google Scholar 

  55. Petersson F, Tan PH, Hwang JS. Sclerosing polycystic adenosis of the parotid gland: report of a bifocal, paucicystic variant with ductal carcinoma in situ and pronounced stromal distortion mimicking invasive carcinoma. Head Neck Pathol. 2011;5(2):188–92.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Gnepp DR. Sclerosing polycystic adenosis of the salivary gland: a lesion that may be associated with dysplasia and carcinoma in situ. Adv Anat Pathol. 2003;10(4):218–22.

    Article  PubMed  Google Scholar 

  57. Gnepp DR, et al. Sclerosing polycystic adenosis of the salivary gland: a report of 16 cases. Am J Surg Pathol. 2006;30(2):154–64.

    Article  PubMed  Google Scholar 

  58. Canas Marques R, Felix A. Invasive carcinoma arising from sclerosing polycystic adenosis of the salivary gland. Virchows Arch. 2014;464(5):621–5.

    Article  PubMed  Google Scholar 

  59. Pieterse AS, Seymour AE. Parotid cysts. An analysis of 16 cases and suggested classification. Pathology. 1981;13(2):225–34.

    Article  CAS  PubMed  Google Scholar 

  60. Islam S, Hoffman GR. Parotid dermoid cyst: a rare entity. J Laryngol Otol. 2009;123(2):e7.

    Article  CAS  PubMed  Google Scholar 

  61. Tas A, et al. Dermoid cyst of the parotid gland: first pediatric case. Int J Pediatr Otorhinolaryngol. 2010;74(2):216–7.

    Article  PubMed  Google Scholar 

  62. Nagao T, et al. Keratocystoma of the parotid gland: a report of two cases of an unusual pathologic entity. Mod Pathol. 2002;15(9):1005–10.

    Article  PubMed  Google Scholar 

  63. Huang XF, et al. Keratocystoma of the parotid gland: a clinicopathological study and literature review. Int J Oral Maxillofac Surg. 2012;41(2):256–60.

    Article  PubMed  Google Scholar 

  64. Simpson R. Myoepithelial tumors of the salivary glands. Curr Diagn Pathol. 2002;8:328–37.

    Google Scholar 

  65. Zarbo RJ, et al. Salivary gland basal cell and canalicular adenomas: immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. Arch Pathol Lab Med. 2000;124(3):401–5.

    CAS  PubMed  Google Scholar 

  66. Zarbo RJ, Regezi JA, Batsakis JG. S-100 protein in salivary gland tumors: an immunohistochemical study of 129 cases. Head Neck Surg. 1986;8(4):268–75.

    Article  CAS  PubMed  Google Scholar 

  67. Barnes EL, Eveson J, Reichart P, Sidransky D. Tumors of the salivary glands. In: World Health Organization classification of tumors. Lyon; 2005.

    Google Scholar 

  68. Seifert G, Miehlke A, Haubrich J, Chilla R. Diseases of the salivary glands. Stuttgart: Thieme; 1986.

    Google Scholar 

  69. Eveson J. Oncocytic and squamous differentiation in salivary glands and tumors. Rev Esp Patol. 1999;32:433–4.

    Google Scholar 

  70. Skalova A, et al. Analysis of collagen isotypes in crystalloid structures of salivary gland tumors. Hum Pathol. 1992;23(7):748–54.

    Article  CAS  PubMed  Google Scholar 

  71. Di Palma S, et al. Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells. J Clin Pathol. 2007;60(5):492–9.

    Article  PubMed  CAS  Google Scholar 

  72. Skalova A, et al. Pleomorphic adenoma of the salivary glands with intravascular tumor deposits: a diagnostic pitfall. Am J Surg Pathol. 2012;36(11):1674–82.

    Article  PubMed  Google Scholar 

  73. Henriksson G, et al. Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer. 1998;82(4):617–20.

    Article  CAS  PubMed  Google Scholar 

  74. Dehner LP, Valbuena L, Perez-Atayde A, Reddick RL, Askin FB, Rosai J. Salivary gland anlage tumor (“congenital pleomorphic adenoma”): a clinicopathologic, immunohistochemical and ultrastructural study of nine cases. Am J Surg Pathol. 1984;18:25–36.

    Article  Google Scholar 

  75. Herrmann BW, Dehner LP, Lieu JE. Congenital salivary gland anlage tumor: a case series and review of the literature. Int J Pediatr Otorhinolaryngol. 2005;69(2):149–56.

    Article  PubMed  Google Scholar 

  76. Tinsa F, et al. Congenital salivary gland anlage tumor of the nasopharynx. Fetal Pediatr Pathol. 2010;29(5):323–9.

    Article  PubMed  Google Scholar 

  77. Gnepp DR, Henley J, Simpson RHW. Salivary and lacrimal glands. In: Diagnostic surgical pathology of the head and neck. 2nd ed. Saunders Elsevier, Philadelphia, PA; 2011.

    Google Scholar 

  78. Simpson RH, Jones H, Beasley P. Benign myoepithelioma of the salivary glands: a true entity? Histopathology. 1995;27(1):1–9.

    Article  CAS  PubMed  Google Scholar 

  79. Ogawa Y, et al. Plasmacytoid cells in salivary-gland pleomorphic adenomas: evidence of luminal cell differentiation. Virchows Arch. 2003;443(5):625–34.

    Article  PubMed  Google Scholar 

  80. Simpson R. Clear cell tumors. Rev Esp Patol. 1999;32:432–3.

    Google Scholar 

  81. Skalova A, et al. Spindle cell myoepithelial tumors of the parotid gland with extensive lipomatous metaplasia. A report of four cases with immunohistochemical and ultrastructural findings. Virchows Arch. 2001;439(6):762–7.

    Google Scholar 

  82. Alos L, et al. Myoepithelial tumors of salivary glands: a clinicopathologic, immunohistochemical, ultrastructural, and flow-cytometric study. Semin Diagn Pathol. 1996;13(2):138–47.

    CAS  PubMed  Google Scholar 

  83. Lin HC, et al. Basal cell adenoma of the sublingual gland. Ann Otol Rhinol Laryngol. 2003;112(12):1066–8.

    Article  PubMed  Google Scholar 

  84. Veeresh M, et al. Basal cell adenoma of the submandibular gland. J Maxillofac Oral Surg. 2010;9(3):289–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Batsakis JG, Luna MA. Basaloid salivary carcinoma. Ann Otol Rhinol Laryngol. 1991;100(9 Pt 1):785–7.

    Article  CAS  PubMed  Google Scholar 

  86. Luna MA, Tortoledo ME, Allen M. Salivary dermal analogue tumors arising in lymph nodes. Cancer. 1987;59(6):1165–9.

    Article  CAS  PubMed  Google Scholar 

  87. Luna MA, et al. Carcinomas ex monomorphic adenoma of salivary glands. J Laryngol Otol. 1989;103(8):756–9.

    Article  CAS  PubMed  Google Scholar 

  88. Seifert G. Histological typing of salivary gland tumors. In: World Health Organization international histological classification of tumors. Berlin: Springer; 1991.

    Google Scholar 

  89. Honda K, et al. Clonal analysis of the epithelial component of Warthin’s tumor. Hum Pathol. 2000;31(11):1377–80.

    Article  CAS  PubMed  Google Scholar 

  90. Seifert G, Bull HG, Donath K. Histologic subclassification of the cystadenolymphoma of the parotid gland. Analysis of 275 cases. Virchows Arch A Pathol Anat Histol. 1980;388(1):13–38.

    Article  CAS  PubMed  Google Scholar 

  91. Batsakis JG, Sneige N, el-Naggar AK. Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol. 1992;101(2 Pt 1):185–8.

    Article  CAS  PubMed  Google Scholar 

  92. Skalova A, et al. Malignancy-simulating change in parotid gland oncocytoma following fine needle aspiration. Report of 3 cases. Pathol Res Pract. 1999;195(6):399–405.

    Article  CAS  PubMed  Google Scholar 

  93. Zhou CX, Gao Y. Oncocytoma of the salivary glands: a clinicopathologic and immunohistochemical study. Oral Oncol. 2009;45(12):e232–8.

    Article  CAS  PubMed  Google Scholar 

  94. Hyde J, et al. Bilateral multinodular oncocytomas of the parotid arising in a background of bilateral oncocytic nodular hyperplasia. Ear Nose Throat J. 2008;87(1):51–4.

    PubMed  Google Scholar 

  95. Ellis G. Clear cell oncocytoma of salivary gland. Hum Pathol. 1988;19:862–7.

    Article  CAS  PubMed  Google Scholar 

  96. Agaimy A, et al. Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma. Am J Surg Pathol. 2013;37(1):128–37.

    Article  PubMed  Google Scholar 

  97. McHugh JB, et al. p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma. Head Neck Pathol. 2007;1(2):123–31.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Weinreb I, et al. Ductal adenomas of salivary gland showing features of striated duct differentiation (‘striated duct adenoma’): a report of six cases. Histopathology. 2010;57(5):707–15.

    Article  PubMed  Google Scholar 

  99. Yuce S, et al. Canalicular adenoma of the palate. J Craniofac Surg. 2012;23(5):e396–8.

    Article  PubMed  Google Scholar 

  100. Oliveira-Santos C, et al. Asymptomatic nodules of the upper lip: report of a canalicular adenoma with immunoprofile presentation. Gerodontology. 2012;29(2):e1121–4.

    Article  PubMed  Google Scholar 

  101. Yoon AJ, et al. Bilateral canalicular adenomas of the upper lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(3):341–3.

    Article  PubMed  Google Scholar 

  102. Queiroz LM, et al. A rare salivary gland neoplasm: multiple canalicular adenoma; a case report. Auris Nasus Larynx. 2004;31(2):189–93.

    Article  PubMed  Google Scholar 

  103. Gnepp DR. My journey into the world of salivary gland sebaceous neoplasms. Head Neck Pathol. 2012;6(1):101–10.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Seethala RR, et al. Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol. 2012;25(1):26–35.

    Article  PubMed  Google Scholar 

  105. Rawlinson NJ, Almarzooqi S, Nicol K. Sebaceous lymphadenoma of the parotid gland in a 13-year-old girl: a case report. Head Neck Pathol. 2010;4(2):144–7.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Brannon RB, Sciubba JJ, Giulani M. Ductal papillomas of salivary gland origin: a report of 19 cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(1):68–77.

    Article  CAS  PubMed  Google Scholar 

  107. Waldron CA, el-Mofty SK, Gnepp DR. Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 1988;66(3):323–33.

    Article  CAS  PubMed  Google Scholar 

  108. Skalova A, et al. Oncocytic cystadenoma of the parotid gland with tyrosine-rich crystals. Pathol Res Pract. 2000;196(12):849–51.

    Article  CAS  PubMed  Google Scholar 

  109. Michal M, Skalova A, Mukensnabl P. Micropapillary carcinoma of the parotid gland arising in mucinous cystadenoma. Virchows Arch. 2000;437(4):465–8.

    Article  CAS  PubMed  Google Scholar 

  110. Chenevert J, et al. DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol. 2012;25(7):919–29.

    Article  CAS  PubMed  Google Scholar 

  111. Skalova A, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34(5):599–608.

    PubMed  Google Scholar 

  112. Hellquist HB, et al. Tumor growth fraction and apoptosis in salivary gland acinic cell carcinomas. Prognostic implications of Ki-67 and bcl-2 expression and of in situ end labelling (TUNEL). J Pathol. 1997;181(3):323–9.

    Google Scholar 

  113. Skalova A, et al. Cell proliferation correlates with prognosis in acinic cell carcinomas of salivary gland origin. Immunohistochemical study of 30 cases using the MIB 1 antibody in formalin-fixed paraffin sections. J Pathol. 1994;173(1):13–21.

    Article  CAS  PubMed  Google Scholar 

  114. Skalova A, et al. Acinic cell carcinoma with high-grade transformation: a report of 9 cases with immunohistochemical study and analysis of TP53 and HER-2/neu genes. Am J Surg Pathol. 2009;33(8):1137–45.

    Article  PubMed  Google Scholar 

  115. Michal M, et al. Well-differentiated acinic cell carcinoma of salivary glands associated with lymphoid stroma. Hum Pathol. 1997;28(5):595–600.

    Article  CAS  PubMed  Google Scholar 

  116. Tognon C, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell. 2002;2(5):367–76.

    Article  CAS  PubMed  Google Scholar 

  117. Bishop JA, et al. Most nonparotid “acinic cell carcinomas” represent mammary analog secretory carcinomas. Am J Surg Pathol. 2013;37(7):1053–7.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Connor A, et al. Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol. 2012;36(1):27–34.

    Article  PubMed  Google Scholar 

  119. Chiosea SI, et al. Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 2012;61(3):387–94.

    Article  PubMed  Google Scholar 

  120. Laco J, et al. Mammary analog secretory carcinoma of salivary glands: a report of 2 cases with expression of basal/myoepithelial markers (calponin, CD10 and p63 protein). Pathol Res Pract. 2013;209(3):167–72.

    Article  CAS  PubMed  Google Scholar 

  121. Chenevert J, Barnes LE, Chiosea SI. Mucoepidermoid carcinoma: a five-decade journey. Virchows Arch. 2011;458(2):133–40.

    Article  PubMed  Google Scholar 

  122. Skalova A, et al. Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, beta-catenin, EGFR, and CCND1 genes. Am J Surg Pathol. 2014;38(1):23–33.

    Article  PubMed  Google Scholar 

  123. Sultan I, et al. Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases. Head Neck. 2011;33(10):1476–81.

    Article  PubMed  Google Scholar 

  124. Stenman G. Fusion oncogenes in salivary gland tumors: molecular and clinical consequences. Head Neck Pathol. 2013;7 Suppl 1:S12–9.

    Article  PubMed  Google Scholar 

  125. Jee KJ, et al. Genomic profiles and CRTC1-MAML2 fusion distinguish different subtypes of mucoepidermoid carcinoma. Mod Pathol. 2013;26(2):213–22.

    Article  CAS  PubMed  Google Scholar 

  126. Luna MA. Salivary mucoepidermoid carcinoma: revisited. Adv Anat Pathol. 2006;13(6):293–307.

    Article  PubMed  Google Scholar 

  127. Tian W, et al. IgG4(+) plasma cells in sclerosing variant of mucoepidermoid carcinoma. Am J Surg Pathol. 2012;36(7):973–9.

    Article  PubMed  Google Scholar 

  128. Brandwein MS, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25(7):835–45.

    Article  CAS  PubMed  Google Scholar 

  129. Skalova A, et al. Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections. Hum Pathol. 1994;25(9):929–35.

    Article  CAS  PubMed  Google Scholar 

  130. Goode RK, Auclair PL, Ellis GL. Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer. 1998;82(7):1217–24.

    Article  CAS  PubMed  Google Scholar 

  131. Altemani A, et al. Signet-ring cell change in adenoid cystic carcinoma: a clinicopathological and immunohistochemical study of four cases. Histopathology. 2013;62(4):531–42.

    Article  PubMed  Google Scholar 

  132. Skalova A, et al. Assessment of proliferative activity using the MIB1 antibody help to distinguish polymorphous low grade adenocarcinoma from adenoid cystic carcinoma of salivary glands. Pathol Res Pract. 1997;193(10):695–703.

    Article  CAS  PubMed  Google Scholar 

  133. Marchio C, Weigelt B, Reis-Filho JS. Adenoid cystic carcinomas of the breast and salivary glands (or ‘The strange case of Dr Jekyll and Mr Hyde’ of exocrine gland carcinomas). J Clin Pathol. 2010;63(3):220–8.

    Article  PubMed  Google Scholar 

  134. Wetterskog D, et al. Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology. 2013;62(4):543–50.

    Article  PubMed  PubMed Central  Google Scholar 

  135. Brill 2nd LB, et al. Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Mod Pathol. 2011;24(9):1169–76.

    Article  CAS  PubMed  Google Scholar 

  136. Di Palma S, et al. Primary sinonasal adenoid cystic carcinoma presenting with skin metastases – genomic profile and expression of the MYB-NFIB fusion biomarker. Histopathology. 2014;64(3):453–5.

    Article  PubMed  Google Scholar 

  137. Ogawa I, et al. Pleomorphic adenoma with extensive adenoid cystic carcinoma-like cribriform areas of parotid gland. Pathol Int. 2003;53(1):30–4.

    Article  PubMed  Google Scholar 

  138. Vargas H, Kaplan S. Mixed tumor, polymorphous low-grade adenocarcinoma and ACC of the salivary gland: pathogenic implications and differential diagnosis by Ki-67 (MIB1), BCL2 and S100 immunohistochemistry. Appl Immunohistochem. 1997;5:8–16.

    Google Scholar 

  139. Szanto PA, et al. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer. 1984;54(6):1062–9.

    Article  CAS  PubMed  Google Scholar 

  140. Seethala RR, et al. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007;31(11):1683–94.

    Article  PubMed  Google Scholar 

  141. Spiro RH, Huvos AG. Stage means more than grade in adenoid cystic carcinoma. Am J Surg. 1992;164(6):623–8.

    Article  CAS  PubMed  Google Scholar 

  142. Kokemueller H, et al. Adenoid cystic carcinoma of the head and neck – a 20 years experience. Int J Oral Maxillofac Surg. 2004;33(1):25–31.

    Article  CAS  PubMed  Google Scholar 

  143. Abu El-Naaj I, et al. Polymorphous low grade adenocarcinoma: case series and review of surgical management. J Oral Maxillofac Surg. 2011;69(7):1967–72.

    Article  PubMed  Google Scholar 

  144. Evans HL, Luna MA. Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol. 2000;24(10):1319–28.

    Article  CAS  PubMed  Google Scholar 

  145. Pogodzinski MS, et al. Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope. 2006;116(12):2145–9.

    Article  PubMed  Google Scholar 

  146. Nagao T, et al. Polymorphous low-grade adenocarcinoma of the major salivary glands: report of three cases in an unusual location. Histopathology. 2004;44(2):164–71.

    Article  CAS  PubMed  Google Scholar 

  147. Tortoledo ME, Luna MA, Batsakis JG. Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol. 1984;110(3):172–6.

    Article  CAS  PubMed  Google Scholar 

  148. Simpson RH, et al. Polymorphous low-grade adenocarcinoma of the salivary glands: a clinicopathological comparison with adenoid cystic carcinoma. Histopathology. 1991;19(2):121–9.

    Article  CAS  PubMed  Google Scholar 

  149. Castle JT, et al. Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. Cancer. 1999;86(2):207–19.

    Article  CAS  PubMed  Google Scholar 

  150. Verma V, Mendenhall WM, Werning JW. Polymorphous low-grade adenocarcinoma of the head and neck. Am J Clin Oncol. 2014;37(6):624–6.

    Google Scholar 

  151. Edwards PC, Bhuiya T, Kelsch RD. C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):586–93.

    Article  PubMed  Google Scholar 

  152. Kemp BL, et al. Terminal duct adenocarcinomas of the parotid gland. J Laryngol Otol. 1995;109(5):466–8.

    Article  CAS  PubMed  Google Scholar 

  153. Parrett TJ, Prasad A, Raslan WF, Kakar S, Lewis JE. Long term and life-long follow-up in polymorphous low grade adenocarcinoma. Mod Pathol. 2002;15:223.

    Google Scholar 

  154. Slootweg PJ. Low-grade adenocarcinoma of the oral cavity: polymorphous or papillary? J Oral Pathol Med. 1993;22(7):327–30.

    Article  CAS  PubMed  Google Scholar 

  155. Simpson RH, et al. Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology. 2002;41(3):250–9.

    Article  CAS  PubMed  Google Scholar 

  156. Michal M, et al. Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. Histopathology. 1999;35(6):495–501.

    Article  CAS  PubMed  Google Scholar 

  157. Skalova A, et al. Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol. 2011;35(8):1168–76.

    Article  PubMed  Google Scholar 

  158. Borowski-Borowy P, et al. Cribriform adenocarcinoma of the tongue. Pol J Pathol. 2011;62(3):168–71.

    PubMed  Google Scholar 

  159. Cocek A, et al. Cribriform adenocarcinoma of the base of the tongue and low-grade, polymorphic adenocarcinomas of the salivary glands. Oncol Lett. 2011;2(1):135–8.

    PubMed  Google Scholar 

  160. Prasad KC, et al. Pedunculated cribriform adenocarcinoma of the base of the tongue. Ear Nose Throat J. 2004;83(1):62–4.

    PubMed  Google Scholar 

  161. Laco J, et al. Cribriform adenocarcinoma of minor salivary glands may express galectin-3, cytokeratin 19, and HBME-1 and contains polymorphisms of RET and H-RAS proto-oncogenes. Virchows Arch. 2012;461(5):531–40.

    Article  CAS  PubMed  Google Scholar 

  162. Li CY, et al. Epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the palate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(4):460–5.

    Article  CAS  PubMed  Google Scholar 

  163. Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31(1):44–57.

    Article  PubMed  Google Scholar 

  164. Mantesso A, et al. Analysis of epithelial-myoepithelial carcinoma based on the establishment of a novel cell line. Oral Oncol. 2003;39(5):453–8.

    Article  CAS  PubMed  Google Scholar 

  165. Cheung FM, Hioe F, Kong JH. Histologic variant of the epithelial-myoepithelial carcinoma of the salivary gland: a case report. Head Neck. 1995;17(5):437–44.

    Article  CAS  PubMed  Google Scholar 

  166. Seethala RR. Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor. Head Neck Pathol. 2013;7 Suppl 1:S77–84.

    Article  PubMed  Google Scholar 

  167. Shinozaki A, et al. Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol. 2008;32(6):913–23.

    Article  PubMed  Google Scholar 

  168. Simpson RH, et al. Epithelial-myoepithelial carcinoma of salivary glands. J Clin Pathol. 1991;44(5):419–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  169. Cardesa A, Slootweg P, editors. Major and minor salivary glands. In: Pathology of the head and neck. Berlin: Springer; 2006.

    Google Scholar 

  170. Fonseca I, Soares J. Epithelial-myoepithelial carcinoma of the salivary glands. A study of 22 cases. Virchows Arch A Pathol Anat Histopathol. 1993;422(5):389–96.

    Article  CAS  PubMed  Google Scholar 

  171. Alos L, et al. High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases. Virchows Arch. 1999;434(4):291–9.

    Article  CAS  PubMed  Google Scholar 

  172. Roy P, et al. Epithelial-myoepithelial carcinoma with high grade transformation. Am J Surg Pathol. 2010;34(9):1258–65.

    Article  PubMed  Google Scholar 

  173. Weinreb I. Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol. 2013;7 Suppl 1:S20–9.

    Article  PubMed  Google Scholar 

  174. Wang B, et al. Primary salivary clear cell tumors – a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Arch Pathol Lab Med. 2002;126(6):676–85.

    PubMed  Google Scholar 

  175. Simpson RH, et al. Clear cell carcinoma of minor salivary glands. Histopathology. 1990;17(5):433–8.

    Article  CAS  PubMed  Google Scholar 

  176. Milchgrub S, et al. Hyalinizing clear cell carcinoma of salivary gland. Am J Surg Pathol. 1994;18(1):74–82.

    Article  CAS  PubMed  Google Scholar 

  177. Dardick I, Leong I. Clear cell carcinoma: review of its histomorphogenesis and classification as a squamous cell lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(3):399–405.

    Article  PubMed  Google Scholar 

  178. Antonescu CR, Katabi N, Zhang L, Seethala RR, Jordan RC, Perez-Ordoñez B, Leong IT, Bradley G, Klieb H, Weinreb I. Rearrangement of the EWSR1 gene is a consistent feature in hyalinising clear cell carcinoma of salivary gland. Modern Pathol. 2011;24(Supplement 1):273.

    Google Scholar 

  179. Tanguay J, Weinreb I. What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma. Head Neck Pathol. 2013;7(1):28–34.

    Article  PubMed  PubMed Central  Google Scholar 

  180. Bilodeau EA, Weinreb I, Antonescu CR, Zhang L, Dacic S, Muller S, Barker B, Seethala RR. Clear cell odontogenic carcinomas show EWSR1 rearrangements: a novel finding and biological link to salivary clear cell carcinomas. Modern Pathol. 2012;25(Supplement 1):305.

    Google Scholar 

  181. O’Sullivan-Mejia ED, et al. Hyalinizing clear cell carcinoma: report of eight cases and a review of literature. Head Neck Pathol. 2009;3(3):179–85.

    Article  PubMed  PubMed Central  Google Scholar 

  182. McCluggage G, et al. Basal cell adenocarcinoma of the submandibular gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(3):342–50.

    Article  CAS  PubMed  Google Scholar 

  183. Petersen SK, et al. Basal cell adenocarcinoma of the sublingual gland. Ugeskr Laeger. 2010;172(7):551–2.

    PubMed  Google Scholar 

  184. Jayakrishnan A, et al. Basal cell adenocarcinoma in minor salivary glands. Histopathology. 2003;42(6):610–4.

    Article  CAS  PubMed  Google Scholar 

  185. Farrell T, Chang YL. Basal cell adenocarcinoma of minor salivary glands. Arch Pathol Lab Med. 2007;131(10):1602–4.

    PubMed  Google Scholar 

  186. Muller S, Barnes L. Basal cell adenocarcinoma of the salivary glands. Report of seven cases and review of the literature. Cancer. 1996;78(12):2471–7.

    Article  CAS  PubMed  Google Scholar 

  187. Antonescu CR, Terzakis JA. Multiple malignant cylindromas of skin in association with basal cell adenocarcinoma with adenoid cystic features of minor salivary gland. J Cutan Pathol. 1997;24(7):449–53.

    Article  CAS  PubMed  Google Scholar 

  188. Nagao T, et al. Basal cell adenocarcinoma of the salivary glands: comparison with basal cell adenoma through assessment of cell proliferation, apoptosis, and expression of p53 and bcl-2. Cancer. 1998;82(3):439–47.

    Article  CAS  PubMed  Google Scholar 

  189. Cui R, et al. Rare cerebral and pulmonary metastases from low-grade basal cell adenocarcinoma of the parotid gland. Clin Nucl Med. 2011;36(12):1124–6.

    Article  PubMed  Google Scholar 

  190. Savera AT, et al. Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 25 patients. Am J Surg Pathol. 2000;24(6):761–74.

    Article  CAS  PubMed  Google Scholar 

  191. Nagao T, et al. Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer. 1998;83(7):1292–9.

    Article  CAS  PubMed  Google Scholar 

  192. Antonescu CR, et al. EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene. Genes Chromosomes Cancer. 2010;49(12):1114–24.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  193. Antonescu CR, et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011;50(7):559–70.

    Article  CAS  PubMed  Google Scholar 

  194. Shah AA, et al. EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol. 2013;37(4):571–8.

    Article  PubMed  Google Scholar 

  195. Skalova A, et al. Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol. 2015;39(3):338–48.

    Article  PubMed  Google Scholar 

  196. Michal M, et al. Clear cell malignant myoepithelioma of the salivary glands. Histopathology. 1996;28(4):309–15.

    Article  CAS  PubMed  Google Scholar 

  197. Di Palma S, Guzzo M. Malignant myoepithelioma of salivary glands: clinicopathological features of ten cases. Virchows Arch A Pathol Anat Histopathol. 1993;423(5):389–96.

    Article  PubMed  Google Scholar 

  198. Salovaara E, et al. Management and outcome of salivary duct carcinoma in major salivary glands. Eur Arch Otorhinolaryngol. 2013;270(1):281–5.

    Article  PubMed  Google Scholar 

  199. Bahrami A, et al. An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions. Histopathology. 2013;63(2):250–62.

    Article  PubMed  Google Scholar 

  200. Hogg RP, Ayshford C, Watkinson JC. Parotid duct carcinoma arising in bilateral chronic sialadenitis. J Laryngol Otol. 1999;113(7):686–8.

    Article  CAS  PubMed  Google Scholar 

  201. Gill J, et al. Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland. Hum Pathol. 2009;40(6):881–6.

    Article  CAS  PubMed  Google Scholar 

  202. Simpson RH. Salivary duct carcinoma: new developments – morphological variants including pure in situ high grade lesions; proposed molecular classification. Head Neck Pathol. 2013;7 Suppl 1:S48–58.

    Article  PubMed  Google Scholar 

  203. Simpson RH, et al. Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol. 2003;27(8):1070–9.

    Article  PubMed  Google Scholar 

  204. Brandwein MS, et al. Salivary duct carcinoma (cribriform salivary carcinoma of excretory ducts). A clinicopathologic and immunohistochemical study of 12 cases. Cancer. 1990;65(10):2307–14.

    Article  CAS  PubMed  Google Scholar 

  205. Nagao T, et al. Invasive micropapillary salivary duct carcinoma: a distinct histologic variant with biologic significance. Am J Surg Pathol. 2004;28(3):319–26.

    Article  PubMed  Google Scholar 

  206. Simpson RHW, Di Palma S. Carcinomas of the salivary gland. In: Underwood J, Pignatelli M, editors. Recent advances in histopathology. London: Royal Society of Medicine Press; 2007. p. 17–43.

    Google Scholar 

  207. Nagao T, et al. Sarcomatoid variant of salivary duct carcinoma: clinicopathologic and immunohistochemical study of eight cases with review of the literature. Am J Clin Pathol. 2004;122(2):222–31.

    Article  PubMed  Google Scholar 

  208. Simpson RH, Desai S, Di Palma S. Salivary duct carcinoma in situ of the parotid gland. Histopathology. 2008;53(4):416–25.

    Article  CAS  PubMed  Google Scholar 

  209. Nikitakis NG, et al. Immunohistochemical expression of cytokeratins 7 and 20 in malignant salivary gland tumors. Mod Pathol. 2004;17(4):407–15.

    Article  PubMed  Google Scholar 

  210. Kapadia SB, Barnes L. Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma. Mod Pathol. 1998;11(11):1033–8.

    CAS  PubMed  Google Scholar 

  211. Skalova A, et al. Expression of HER-2/neu gene and protein in salivary duct carcinomas of parotid gland as revealed by fluorescence in-situ hybridization and immunohistochemistry. Histopathology. 2003;42(4):348–56.

    Article  CAS  PubMed  Google Scholar 

  212. Di Palma S, et al. Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes*. Histopathology. 2012;61(4):629–43.

    PubMed  Google Scholar 

  213. Williams MD, et al. Differential expression of hormonal and growth factor receptors in salivary duct carcinomas: biologic significance and potential role in therapeutic stratification of patients. Am J Surg Pathol. 2007;31(11):1645–52.

    Article  PubMed  Google Scholar 

  214. Barnes L, et al. Salivary duct carcinoma. Part II. Immunohistochemical evaluation of 13 cases for estrogen and progesterone receptors, cathepsin D, and c-erbB-2 protein. Oral Surg Oral Med Oral Pathol. 1994;78(1):74–80.

    Article  CAS  PubMed  Google Scholar 

  215. Moriki T, et al. Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosis. Cancer. 2001;93(5):344–50.

    Article  CAS  PubMed  Google Scholar 

  216. Fan CY, Wang J, Barnes EL. Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature. Am J Surg Pathol. 2000;24(4):579–86.

    Article  CAS  PubMed  Google Scholar 

  217. Kay PA, Roche P, Olsen KD, Lewis JE. Salivary duct carcinoma: immunohistochemical analysis of androgen receptor, prostate markers and HER-2/neu oncoprotein in 40 cases. Mod Pathol. 2001;14:150.

    Article  Google Scholar 

  218. Simpson RH, et al. Salivary duct adenocarcinoma. Histopathology. 1991;18(3):229–35.

    Article  CAS  PubMed  Google Scholar 

  219. Kuo YJ, Weinreb I, Perez-Ordonez B. Low-grade salivary duct carcinoma or low-grade intraductal carcinoma? Review of the literature. Head Neck Pathol. 2013;7 Suppl 1:S59–67.

    Article  PubMed  Google Scholar 

  220. Locati LD, Bossi B, Rinaldi GR, Bergamini CB, Quattrone Q, Staurengo S, Pilotti S, Licitra L. Anti-androgen therapy in recurrent and/or metastatic salivary glands carcinoma (RSGC). Ann Oncol. 2006;16:38.

    Google Scholar 

  221. Di Palma S, Whitaker S, Potter K, Pitkin L. Carcinoma ex pleomorphic adenoma successfully treated with trastuzumab and radiotherapy. Virchow Archiv. 2012;461 Suppl 1:S144.

    Google Scholar 

  222. Falchook GS, et al. Human epidermal receptor 2-amplified salivary duct carcinoma: regression with dual human epidermal receptor 2 inhibition and anti-vascular endothelial growth factor combination treatment. Head Neck. 2014;36(3):E25–7.

    Article  PubMed  Google Scholar 

  223. Griffith CC, et al. PIK3CA mutations and PTEN loss in salivary duct carcinomas. Am J Surg Pathol. 2013;37(8):1201–7.

    Article  PubMed  Google Scholar 

  224. Hui KK, et al. Salivary duct adenocarcinoma: a high grade malignancy. J Laryngol Otol. 1986;100(1):105–14.

    Article  CAS  PubMed  Google Scholar 

  225. Colmenero Ruiz C, Patron Romero M, Martin Perez M. Salivary duct carcinoma: a report of nine cases. J Oral Maxillofac Surg. 1993;51(6):641–6.

    Article  CAS  PubMed  Google Scholar 

  226. Guzzo M, et al. Salivary duct carcinoma: clinical characteristics and treatment strategies. Head Neck. 1997;19(2):126–33.

    Article  CAS  PubMed  Google Scholar 

  227. Delgado R, Klimstra D, Albores-Saavedra J. Low grade salivary duct carcinoma. A distinctive variant with a low grade histology and a predominant intraductal growth pattern. Cancer. 1996;78(5):958–67.

    Article  CAS  PubMed  Google Scholar 

  228. Brandwein-Gensler M, et al. Low-grade salivary duct carcinoma: description of 16 cases. Am J Surg Pathol. 2004;28(8):1040–4.

    Article  PubMed  Google Scholar 

  229. Weinreb I, et al. Low-grade intraductal carcinoma of salivary gland: report of 3 cases with marked apocrine differentiation. Am J Surg Pathol. 2006;30(8):1014–21.

    Article  PubMed  Google Scholar 

  230. Yakirevich E, et al. Primary mucin-producing tumors of the salivary glands: a clinicopathological and morphometric study. Histopathology. 2010;57(3):395–409.

    Google Scholar 

  231. Ghannoum JE, Freedman PD. Signet-ring cell (mucin-producing) adenocarcinomas of minor salivary glands. Am J Surg Pathol. 2004;28(1):89–93.

    Article  PubMed  Google Scholar 

  232. Esteva CJ, Slater L, Gnepp DR. Mucinous myoepithelioma, a previously unrecognized variant. Mod Pathol. 2012;92 Suppl 2:308.

    Google Scholar 

  233. Gnepp DR. Mucinous myoepithelioma, a recently described new myoepithelioma variant. Head Neck Pathol. 2013;7 Suppl 1:S85–9.

    Article  PubMed  Google Scholar 

  234. Zhou CX, et al. Primary oncocytic carcinoma of the salivary glands: a clinicopathologic and immunohistochemical study of 12 cases. Oral Oncol. 2010;46(10):773–8.

    Article  CAS  PubMed  Google Scholar 

  235. Lee TH, et al. Malignant transformation of a benign oncocytoma of the submandibular gland: a case report. Kaohsiung J Med Sci. 2010;26(6):327–32.

    Article  PubMed  Google Scholar 

  236. Therkildsen MH, et al. Malignant Warthin’s tumor: a case study. Histopathology. 1992;21(2):167–71.

    Google Scholar 

  237. Weiler C, et al. Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation of 41 cases. Histopathology. 2011;59(4):741–50.

    Article  PubMed  Google Scholar 

  238. Di Palma S. Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol. 2013;7 Suppl 1:S68–76.

    Article  PubMed  Google Scholar 

  239. Chen HH, et al. Carcinoma ex pleomorphic adenoma of soft palate with cavernous sinus invasion. World J Surg Oncol. 2010;8:24.

    Article  PubMed  PubMed Central  Google Scholar 

  240. Toluie S, Thompson LD. Sinonasal tract adenoid cystic carcinoma ex-pleomorphic adenoma: a clinicopathologic and immunophenotypic study of 9 cases combined with a comprehensive review of the literature. Head Neck Pathol. 2012;6(4):409–21.

    Article  PubMed  PubMed Central  Google Scholar 

  241. LiVolsi VA, Perzin KH. Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study. Cancer. 1977;39(5):2209–30.

    Article  CAS  PubMed  Google Scholar 

  242. Gnepp DR. Malignant mixed tumors of the salivary glands: a review. Pathol Annu. 1993;28(Pt 1):279–328.

    PubMed  Google Scholar 

  243. Nagao K, et al. Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland. Cancer. 1981;48(1):113–21.

    Article  CAS  PubMed  Google Scholar 

  244. Lewis JE, Olsen KD, Sebo TJ. Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases. Hum Pathol. 2001;32(6):596–604.

    Article  CAS  PubMed  Google Scholar 

  245. Auclair PL, Ellis GL. Atypical features in salivary gland mixed tumors: their relationship to malignant transformation. Mod Pathol. 1996;9(6):652–7.

    CAS  PubMed  Google Scholar 

  246. Ihrler S, et al. Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53. Histopathology. 2007;51(3):362–71.

    Article  CAS  PubMed  Google Scholar 

  247. Di Palma S. Malignancy in pleomorphic adenoma (malignant mixed tumor) of salivary glands. In: Proceedings in head and neck pathology. Ljubljana: University of Ljubljana; 2003.

    Google Scholar 

  248. El-Naggar AK, et al. Molecular genetic alterations in carcinoma ex-pleomorphic adenoma: a putative progression model? Genes Chromosomes Cancer. 2000;27(2):162–8.

    Article  CAS  PubMed  Google Scholar 

  249. Kujan O, et al. The expression of FHIT in salivary carcinoma ex pleomorphic adenoma. Anticancer Res. 2012;32(8):3147–52.

    PubMed  Google Scholar 

  250. Antony J, et al. Carcinoma ex pleomorphic adenoma: a comprehensive review of clinical, pathological and molecular data. Head Neck Pathol. 2012;6(1):1–9.

    Article  PubMed  Google Scholar 

  251. Olsen KD, Lewis JE. Carcinoma ex pleomorphic adenoma: a clinicopathologic review. Head Neck. 2001;23(9):705–12.

    Article  CAS  PubMed  Google Scholar 

  252. Brandwein M, et al. Noninvasive and minimally invasive carcinoma ex mixed tumor: a clinicopathologic and ploidy study of 12 patients with major salivary tumors of low (or no?) malignant potential. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;81(6):655–64.

    Article  CAS  PubMed  Google Scholar 

  253. Di Palma S, et al. Non-invasive (intracapsular) carcinoma ex pleomorphic adenoma: recognition of focal carcinoma by HER-2/neu and MIB1 immunohistochemistry. Histopathology. 2005;46(2):144–52.

    Article  PubMed  Google Scholar 

  254. Zhao J, et al. Prognostic factors affecting the clinical outcome of carcinoma ex pleomorphic adenoma in the major salivary gland. World J Surg Oncol. 2013;11(1):180.

    Article  PubMed  PubMed Central  Google Scholar 

  255. Sharon E, Kelly RJ, Szabo E. Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine. Head Neck Oncol. 2010;2:12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  256. Hashimoto K, et al. HER-2/neu gene amplification in carcinoma ex pleomorphic adenoma in relation to progression and prognosis: a chromogenic in-situ hybridization study. Histopathology. 2012;60(6b):E131–42.

    Article  PubMed  Google Scholar 

  257. DeRoche TC, Hoschar AP, Hunt JL. Immunohistochemical evaluation of androgen receptor, HER-2/neu, and p53 in benign pleomorphic adenomas. Arch Pathol Lab Med. 2008;132(12):1907–11.

    PubMed  Google Scholar 

  258. Altemani A, et al. Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology. 2005;46(6):635–41.

    Article  CAS  PubMed  Google Scholar 

  259. Katabi N, et al. Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. Hum Pathol. 2010;41(7):927–34.

    Article  PubMed  Google Scholar 

  260. Felix A, et al. Intracapsular carcinoma ex pleomorphic adenoma. Report of a case with unusual metastatic behaviour. Oral Oncol. 2002;38(1):107–10.

    Article  CAS  PubMed  Google Scholar 

  261. Stephen J, et al. True malignant mixed tumors (carcinosarcoma) of salivary glands. Oral Surg Oral Med Oral Pathol. 1986;61(6):597–602.

    Article  CAS  PubMed  Google Scholar 

  262. Tanahashi J, et al. Carcinosarcoma ex recurrent pleomorphic adenoma of the submandibular gland. Apmis. 2007;115(6):789–94.

    Article  PubMed  Google Scholar 

  263. Petersson F, Loh KS. Carcinosarcoma ex non-recurrent pleomorphic adenoma composed of TTF-1 positive large cell neuroendocrine carcinoma and myofibrosarcoma: apropos a rare Case. Head Neck Pathol. 2013;7(2):163–70.

    Article  PubMed  Google Scholar 

  264. Vekony H, et al. Salivary gland carcinosarcoma: oligonucleotide array CGH reveals similar genomic profiles in epithelial and mesenchymal components. Oral Oncol. 2009;45(3):259–65.

    Article  CAS  PubMed  Google Scholar 

  265. Nouraei SA, et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg. 2006;132(7):788–93.

    Article  CAS  PubMed  Google Scholar 

  266. Santaliz-Ruiz LE, et al. Metastasizing pleomorphic adenoma: a fascinating enigma. Case Rep Med. 2012;2012:148103.

    PubMed  PubMed Central  Google Scholar 

  267. Manucha V, Ioffe OB. Metastasizing pleomorphic adenoma of the salivary gland. Arch Pathol Lab Med. 2008;132(9):1445–7.

    PubMed  Google Scholar 

  268. Tarsitano A, et al. Metastasizing “benign” pleomorphic salivary adenoma: a dramatic case-report and literature review. J Craniomaxillofac Surg. 2014;268:42(8):1562–5.

    Google Scholar 

  269. Wenig BM, et al. Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol. 1992;16(9):845–58.

    Article  CAS  PubMed  Google Scholar 

  270. Bradley PJ. ‘Metastasizing pleomorphic salivary adenoma’ should now be considered a low-grade malignancy with a lethal potential. Curr Opin Otolaryngol Head Neck Surg. 2005;13(2):123–6.

    Article  PubMed  Google Scholar 

  271. el-Naggar A, Batsakis JG, Kessler S. Benign metastatic mixed tumors or unrecognized salivary carcinomas? J Laryngol Otol. 1988;102(9):810–2.

    Google Scholar 

  272. Bae CH, Kim YD, Song SY. Benign pleomorphic adenoma of the soft palate metastasizing to the sphenoid sinus. Clin Exp Otorhinolaryngol. 2010;3(3):172–5.

    Article  PubMed  PubMed Central  Google Scholar 

  273. Di Palma S, Skálová A. Malignancy in pleomorphic adenoma. Rev Esp Patol. 1999;32:431–2.

    Google Scholar 

  274. Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer. 1984;53(10):2155–70.

    Article  CAS  PubMed  Google Scholar 

  275. Gnepp DR. Sebaceous neoplasms of salivary gland origin: a review. Pathol Annu. 1983;18(Pt 1):71–102.

    PubMed  Google Scholar 

  276. Wang H, et al. Sebaceous carcinoma of the oral cavity: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(2):e37–40.

    Article  PubMed  Google Scholar 

  277. Cohn ML, Callender DL, El-Naggar AK. Sebaceous carcinoma ex-pleomorphic adenoma: a rare phenotypic occurrence. Ann Diagn Pathol. 2004;8(4):224–6.

    Article  PubMed  Google Scholar 

  278. Altemani A, et al. Sebaceous carcinoma of the parotid gland in children: an immunohistochemical and ploidy study. Int J Oral Maxillofac Surg. 2008;37(5):433–40.

    Article  CAS  PubMed  Google Scholar 

  279. Claudius K, et al. A red cheek as first clinical sign of a sebaceous lymphadenocarcinoma of the parotid gland with lymphangiosis carcinomatosa and lymph node metastases. Am J Dermatopathol. 2011;33(4):e50–3.

    Article  PubMed  Google Scholar 

  280. Croitoru CM, Mooney JE, Luna MA. Sebaceous lymphadenocarcinoma of salivary glands. Ann Diagn Pathol. 2003;7(4):236–9.

    Article  PubMed  Google Scholar 

  281. Shukla M, Panicker S. Synchronous sebaceous lymphadenoma with squamous cell carcinoma – case report. World J Surg Oncol. 2003;1(1):30.

    Article  PubMed  PubMed Central  Google Scholar 

  282. Ahn SH, Park SY. Sebaceous lymphadenocarcinoma of parotid gland. Eur Arch Otorhinolaryngol. 2006;263(10):940–2.

    Article  PubMed  Google Scholar 

  283. Albeck H, et al. Familial clusters of nasopharyngeal carcinoma and salivary gland carcinomas in Greenland natives. Cancer. 1993;72(1):196–200.

    Article  CAS  PubMed  Google Scholar 

  284. Gupta S, Loh KS, Petersson F. Lymphoepithelial carcinoma of the parotid gland arising in an intraglandular lymph node: report of a rare case mimicking metastasis. Ann Diagn Pathol. 2012;16(5):416–21.

    Article  PubMed  Google Scholar 

  285. Amit S, Agarwal A, Khan L. Cytomorphological features of lymphoepithelial carcinoma of submandibular gland in an adolescent male. J Cytol. 2012;29(3):216–8.

    Article  PubMed  PubMed Central  Google Scholar 

  286. Nakao K, et al. Detection of Epstein-Barr virus in metastatic lymph nodes of patients with nasopharyngeal carcinoma and a primary unknown carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129(3):338–40.

    Article  PubMed  Google Scholar 

  287. Spencer CR, et al. Lymphoepithelial carcinoma of the parotid gland: a rare neck lump. JRSM Short Rep. 2012;3(5):28.

    Article  PubMed  PubMed Central  Google Scholar 

  288. Chong VF, Fan YF. Parotid gland involvement in nasopharyngeal carcinoma. J Comput Assist Tomogr. 1999;23(4):524–8.

    Article  CAS  PubMed  Google Scholar 

  289. Liu FY, et al. 18F-FDG PET can replace conventional work-up in primary M staging of nonkeratinizing nasopharyngeal carcinoma. J Nucl Med. 2007;48(10):1614–9.

    Article  PubMed  Google Scholar 

  290. Myers JN, Peel RL, Myers EN. Pathologic quiz case 1. Malignant lymphoepithelial lesion of the parotid gland. Arch Otolaryngol Head Neck Surg. 1995;121(4):479–82.

    Article  CAS  PubMed  Google Scholar 

  291. Gnepp DR, Corio RL, Brannon RB. Small cell carcinoma of the major salivary glands. Cancer. 1986;58(3):705–14.

    Article  CAS  PubMed  Google Scholar 

  292. Nagao T, et al. Small cell carcinoma of the major salivary glands: clinicopathologic study with emphasis on cytokeratin 20 immunoreactivity and clinical outcome. Am J Surg Pathol. 2004;28(6):762–70.

    Article  PubMed  Google Scholar 

  293. Chan JK, et al. Cytokeratin 20 immunoreactivity distinguishes Merkel cell (primary cutaneous neuroendocrine) carcinomas and salivary gland small cell carcinomas from small cell carcinomas of various sites. Am J Surg Pathol. 1997;21(2):226–34.

    Article  CAS  PubMed  Google Scholar 

  294. Batsakis JG, Luna MA. Undifferentiated carcinomas of salivary glands. Ann Otol Rhinol Laryngol. 1991;100(1):82–4.

    Article  CAS  PubMed  Google Scholar 

  295. Kraemer BB, Mackay B, Batsakis JG. Small cell carcinomas of the parotid gland. A clinicopathologic study of three cases. Cancer. 1983;52(11): 2115–21.

    Google Scholar 

  296. Chernock RD, Duncavage EJ, Gnepp DR, El-Mofty SK, Lewis J, editors. Absence of polyoma virus in primary parotid high grade neuroendocrine carcinomas. Modern Pathol. 2011;24(Suppl 1):276A

    Google Scholar 

  297. Cheuk W, et al. Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch Pathol Lab Med. 2001;125(2):228–31.

    Google Scholar 

  298. Said-Al-Naief N, Sciandra K, Gnepp DR. Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the parotid gland: report of three cases with contemporary review of salivary neuroendocrine carcinomas. Head and Neck Pathol. 2013;7(3):295–303.

    Article  Google Scholar 

  299. Modlin IM, Shapiro MD, Kidd M. Primary carcinoid tumor of the parotid gland: a case report and review of the literature. Ear Nose Throat J. 2006;85(8):533–9.

    PubMed  Google Scholar 

  300. Pang B, et al. Desmoplastic small round cell tumor of major salivary glands: report of 1 case and a review of the literature. Appl Immunohistochem Mol Morphol. 2011;19(1):70–5.

    Google Scholar 

  301. Yin WH, et al. Desmoplastic small round cell tumor of the submandibular gland – a rare but distinctive primary salivary gland neoplasm. Hum Pathol. 2010;41(3):438–42.

    Article  PubMed  Google Scholar 

  302. Dahlin DC, Beabout JW. Dedifferentiation of low-grade chondrosarcomas. Cancer. 1971;28(2):461–6.

    Article  CAS  PubMed  Google Scholar 

  303. Evans HL. Liposarcoma and atypical lipomatous tumors: a study of 66 cases followed for a minimum of 10 years. Surg Pathol. 1988;1:41–54.

    Google Scholar 

  304. Cheuk W, Chan JK, Ngan RK. Dedifferentiation in adenoid cystic carcinoma of salivary gland: an uncommon complication associated with an accelerated clinical course. Am J Surg Pathol. 1999;23(4):465–72.

    Article  CAS  PubMed  Google Scholar 

  305. Nagao T, et al. Dedifferentiated adenoid cystic carcinoma: a clinicopathologic study of 6 cases. Mod Pathol. 2003;16(12):1265–72.

    Google Scholar 

  306. Di Palma S, et al. Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland. Virchows Arch. 1999;434(4):361–5.

    Google Scholar 

  307. Gnepp D. Metastatic disease to the major salivary glands. In: Auclair P, Ellis GL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: Saunders; 1991. p. 560–9.

    Google Scholar 

  308. Bergersen PJ, Kennedy PJ, Kneale KL. Metastatic tumors of the parotid region. Aust N Z J Surg. 1987;57(1):23–6.

    Google Scholar 

  309. Simpson RH, Skalova A. Metastatic carcinoma of the prostate presenting as parotid tumor. Histopathology. 1997;30(1):70–4.

    Google Scholar 

  310. Vessecchia G, Di Palma S, Giardini R. Submandibular gland metastasis of breast carcinoma: a case report and review of the literature. Virchows Arch. 1995;427(3):349–51.

    Article  CAS  PubMed  Google Scholar 

  311. Ying YL, Johnson JT, Myers EN. Squamous cell carcinoma of the parotid gland. Head Neck. 2006;28(7):626–32.

    Article  PubMed  Google Scholar 

  312. Nuyens M, et al. Metastatic disease to the parotid gland. Otolaryngol Head Neck Surg. 2006;135(6):844–8.

    Article  PubMed  Google Scholar 

  313. Croitoru CM, Suarez PA, Luna MA. Hybrid carcinomas of salivary glands. Report of 4 cases and review of the literature. Arch Pathol Lab Med. 1999;123(8):698–702.

    CAS  PubMed  Google Scholar 

  314. Viva E, et al. Endodermal sinus (yolk sac) tumor of the parotid gland: a case report. Int J Pediatr Otorhinolaryngol. 1992;24(3):269–74.

    Article  CAS  PubMed  Google Scholar 

  315. Sredni ST, et al. Endodermal sinus tumor of the parotid gland in a child. Pediatr Dev Pathol. 2004;7(1):77–80.

    Article  PubMed  Google Scholar 

  316. Vawter GF, Tefft M. Congenital tumors of the parotid gland. Arch Pathol. 1966;82(3):242–5.

    CAS  PubMed  Google Scholar 

  317. Taylor GP. Congenital epithelial tumor of the parotid-sialoblastoma. Pediatr Pathol. 1988;8(4):447–52.

    Article  CAS  PubMed  Google Scholar 

  318. Adkins GF. Low grade basaloid adenocarcinoma of salivary gland in childhood – the so-called hybrid basal cell adenoma – adenoid cystic carcinoma. Pathology. 1990;22(4):187–90.

    Article  CAS  PubMed  Google Scholar 

  319. Brandwein M, et al. Sialoblastoma: clinicopathological/immunohistochemical study. Am J Surg Pathol. 1999;23(3):342–8.

    Article  CAS  PubMed  Google Scholar 

  320. Batsakis JG, Frankenthaler R. Embryoma (sialoblastoma) of salivary glands. Ann Otol Rhinol Laryngol. 1992;101(11):958–60.

    Article  CAS  PubMed  Google Scholar 

  321. Simpson RH, Sarsfield P. Benign and malignant lymphoid lesions of the salivary glands. Curr Diagn Pathol. 1997;4:91–9.

    Article  Google Scholar 

  322. Ihrler S, Harrison JD. Mikulicz’s disease and Mikulicz’s syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(3):334–9.

    Article  PubMed  Google Scholar 

  323. Ihrler S, et al. Lymphoepithelial duct lesions in Sjogren-type sialadenitis. Virchows Arch. 1999;434(4):315–23.

    Article  CAS  PubMed  Google Scholar 

  324. Daniels T. Benign lymphoepithelial lesion and Sjogren’s syndrome. In: Auclair P, Ellis GL, Gnepp DR, editors. Surgical pathology of the salivary glands. Philadelphia: Saunders; 1991. p. 83–106.

    Google Scholar 

  325. Fox RI, Kang HI. Pathogenesis of Sjogren’s syndrome. Rheum Dis Clin North Am. 1992;18(3):517–38.

    CAS  PubMed  Google Scholar 

  326. Mavragani CP, Moutsopoulos HM. Sjogren’s syndrome. Annu Rev Pathol. 2014;9:273–85.

    Article  CAS  PubMed  Google Scholar 

  327. Haddad J, et al. Lymphocytic sialadenitis of Sjogren’s syndrome associated with chronic hepatitis C virus liver disease. Lancet. 1992;339(8789):321–3.

    Article  CAS  PubMed  Google Scholar 

  328. Tincani A, et al. Novel aspects of Sjogren’s syndrome in 2012. BMC Med. 2013;11:93.

    Article  PubMed  PubMed Central  Google Scholar 

  329. Gleeson MJ, Cawson RA, Bennett MH. Benign lymphoepithelial lesion: a less than benign disease. Clin Otolaryngol Allied Sci. 1986;11(1):47–51.

    Article  CAS  PubMed  Google Scholar 

  330. Isaacson PG, Norton A. Malignant lymphoma of the salivary glands. In: Norton A, Isaacson PG, editors. Extranodal lymphomas. Edinburgh: Churchill-Livingstone; 1994. p. 67–83.

    Google Scholar 

  331. Tzioufas AG, Kapsogeorgou EK, Moutsopoulos HM. Pathogenesis of Sjogren’s syndrome: what we know and what we should learn. J Autoimmun. 2012;39(1–2):4–8.

    Article  CAS  PubMed  Google Scholar 

  332. Quintana PG, et al. Salivary gland lymphoid infiltrates associated with lymphoepithelial lesions: a clinicopathologic, immunophenotypic, and genotypic study. Hum Pathol. 1997;28(7):850–61.

    Article  CAS  PubMed  Google Scholar 

  333. Daniels TE, Fox PC. Salivary and oral components of Sjogren’s syndrome. Rheum Dis Clin North Am. 1992;18(3):571–89.

    CAS  PubMed  Google Scholar 

  334. Ellis GL, Auclair P. Malignant epithelial tumors. In: Atlas of tumor pathology. Washington, DC: AFIP; 1996.

    Google Scholar 

  335. Isaacson PG, Chott A, Nakamura S. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In: Campo E, Swerdlow SH, Harris NL, et al., editors. WHO classification of tumors of haematopoetic and lymphoid tissue. Lyon: IARC; 2008. p. 214–9.

    Google Scholar 

  336. Giannouli S, Voulgarelis M. Predicting progression to lymphoma in Sjogren’s syndrome patients. Expert Rev Clin Immunol. 2014;10(4):501–512.

    Google Scholar 

  337. Suchy BH, Wolf SR. Bilateral mucosa-associated lymphoid tissue lymphoma of the parotid gland. Arch Otolaryngol Head Neck Surg. 2000;126(2):224–6.

    Article  CAS  PubMed  Google Scholar 

  338. Isaacson PG, et al. Follicular colonization in B-cell lymphoma of mucosa-associated lymphoid tissue. Am J Surg Pathol. 1991;15(9):819–28.

    Article  CAS  PubMed  Google Scholar 

  339. Chan JK, et al. T- and T/natural killer-cell lymphomas of the salivary gland: a clinicopathologic, immunohistochemical and molecular study of six cases. Hum Pathol. 1997;28(2):238–45.

    Article  CAS  PubMed  Google Scholar 

  340. Isaacson PG. Malignant lymphomas with a follicular growth pattern. Histopathology. 1996;28(6):487–95.

    Article  CAS  PubMed  Google Scholar 

  341. Jaffe ES, Harris N, Stein H, Vardiman JW. World Health Organization classification of tumors: tumors of haematopoietic and lymphoid tissues. Berlin: Springer; 2001.

    Google Scholar 

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Authors and Affiliations

  1. Department of Histopathology, Royal Surrey County Hospital, University of Surrey, Egerton Road, Guildford, GU2 7XX, Surrey, UK

    Silvana Di Palma MD, FRCPath

  2. Department of Anatomical Pathology, Foothills Medical Centre, University of Calgary, 1403, 29th Street NW, Calgary, T2N 2T9, AB, Canada

    Roderick H. W. Simpson MD

  3. Department of Pathology, Faculty of Medicine in Plzen, Charles University Prague, Plzen, Czech Republic

    Alena Skalova MD, PhD

  4. Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

    Isabel Fonseca MD, PhD

  5. Serviço de Anatomia Patológica, Instituto Português de Oncologia Francisco Gentil - Lisboa, Lisbon, Portugal

    Isabel Fonseca MD, PhD

  6. Department of Pathology and Forensic Medicine, Institute of Biomedicine, University of Turku, Turku, Finland

    Ilmo Leivo MD, PhD

  7. Laboratory for Dermatopathology and Oral Pathology, Munich, Germany

    Stephan Ihrler

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  1. Silvana Di Palma MD, FRCPath
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  2. Roderick H. W. Simpson MD
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  3. Alena Skalova MD, PhD
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  4. Isabel Fonseca MD, PhD
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  5. Ilmo Leivo MD, PhD
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  6. Stephan Ihrler
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Correspondence to Silvana Di Palma MD, FRCPath .

Editor information

Editors and Affiliations

  1. University of Barcelona, Anatomic Pathology Hospital Clínic University of Barcelona, Barcelona, Spain

    Antonio Cardesa

  2. Radboud Univ Nijmegen Medical Center, Pathology Radboud Univ Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter J. Slootweg

  3. University of Ljubljana,, Institute of Pathology, Faculty of Medic University of Ljubljana,, Ljublijana, Slovenia

    Nina Gale

  4. University of Florence, Dept of Surg & Translational Medicine University of Florence, Florence, Italy

    Alessandro Franchi

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Di Palma, S., Simpson, R.H.W., Skalova, A., Fonseca, I., Leivo, I., Ihrler, S. (2016). Major and Minor Salivary Glands. In: Cardesa, A., Slootweg, P., Gale, N., Franchi, A. (eds) Pathology of the Head and Neck. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49672-5_5

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