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Pathology of the Head and Neck pp 673–751Cite as

Common Skin Tumors of the Head and Neck

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Abstract

The purpose of this chapter is to provide a general overview on the most relevant clinical features, histopathological findings and molecular profiles of common and rare cutaneous tumor and tumor-like lesions occurring in the head and neck region. At the molecular level, the most common non-melanoma skin cancers in the head and neck show molecular alterations related to UV exposure. Melanoma subtypes, such as lentigo maligna melanoma and desmoplastic melanoma, which are more often seen on the chronically sun-damaged skin of the head and neck, show a peculiar molecular signature that may potentially affect treatment strategies. Interestingly, some adnexal neoplasms affecting this region may reflect hereditary conditions. Rare cutaneous lesions of different lines of differentiation in this location can often provide a challenging diagnosis due to wide morphological differential diagnosis. The treatment of skin cancer in the head and neck region crosses numerous medical and surgical specialties. Aggressive malignancies are often identified late, and patient outcomes are unsatisfactory, with potentially avoidable morbidity and mortality.

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Authors and Affiliations

  1. Division of Pathology, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, Florence, 50134, Italy

    Daniela Massi MD

  2. Institute of Pathology, Medical Faculty University of Ljubljana, Korytkova 2, Ljubljana, 1000, Slovenia

    Boštjan Luzar MD, PhD

  3. Department of Pathology, Hospital Clinic, University of Barcelona, Villarroel 170, Barcelona, 08036, Spain

    Llucia Alos MD, PhD

Authors
  1. Daniela Massi MD
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  2. Boštjan Luzar MD, PhD
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  3. Llucia Alos MD, PhD
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Correspondence to Daniela Massi MD .

Editor information

Editors and Affiliations

  1. University of Barcelona, Anatomic Pathology Hospital Clínic University of Barcelona, Barcelona, Spain

    Antonio Cardesa

  2. Radboud Univ Nijmegen Medical Center, Pathology Radboud Univ Nijmegen Medical Center, Nijmegen, The Netherlands

    Pieter J. Slootweg

  3. University of Ljubljana,, Institute of Pathology, Faculty of Medic University of Ljubljana,, Ljublijana, Slovenia

    Nina Gale

  4. University of Florence, Dept of Surg & Translational Medicine University of Florence, Florence, Italy

    Alessandro Franchi

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Massi, D., Luzar, B., Alos, L. (2016). Common Skin Tumors of the Head and Neck. In: Cardesa, A., Slootweg, P., Gale, N., Franchi, A. (eds) Pathology of the Head and Neck. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49672-5_15

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