Skip to main content
SpringerLink
Log in

Psychoneuroendokrinologische Grundlagen psychischer Erkrankungen

  • Chapter
  • First Online:
Psychiatrie, Psychosomatik, Psychotherapie

Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Psychische Erkrankungen weisen eine komplexe Pathopysiologie auf, die bis heute nur ansatzweise geklärt ist. Neben Veränderungen von Neurotransmittersystemen und Rezeptoren als deren Effektorsysteme, die dann auf nachgeschaltete Signaltransduktionsprozesse einwirken, mehren sich Hinweise, dass neuroendokrinologische Mechanismen eine wichtige Rolle in der Pathophysiologie psychischer Erkrankungen spielen. Mittlerweile gibt es auch erste Ansätze, die versuchen, derartige Mechanismen im Sinne von neuartigen Therapiestrategien nutzbar zu machen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Literatur

  • Anacker C, Zunszain PA, Cavalho LA, PAriante CM (2011) The glucocorticoid receptor: pivot of depression and antidepressant treatment? Psychoneuroendocrinology 36:415–425

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bauer M, Hellweg R, Gräf KJ, Baumgartner A (1998) Treatment of refractory depression with high-dose thyroxine. Neuropsychopharmacology 18:444–455

    Article  CAS  PubMed  Google Scholar 

  • Baulieu EE (1991) Neurosteroids: a new function in the brain. Biol Cell 71:3–10

    Article  CAS  PubMed  Google Scholar 

  • Behl C, Skutella T, Lezoualc’H F et al (1997) Neuroprotection of against oxidative stress by estrogens: structure-activity relationship. Mol Pharmacol 51:535–541

    Article  CAS  PubMed  Google Scholar 

  • Binder E, Salyakina D, Lichtner P et al (2004) Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet 36:1319–1325

    Article  CAS  PubMed  Google Scholar 

  • Binneman B, Feltner D, Kolluri S et al (2008) A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression. Am J Psychiatry 165:617–620

    Article  PubMed  Google Scholar 

  • Brockington IF, Meakin CJ (1994) Clinical clues to the aetiology of puerperal psychosis. Prog Neuropsychopharmacol Biol Psychiatry 18:417–429

    Article  CAS  PubMed  Google Scholar 

  • Checkley SA, Wieck A, Marks M et al (1992) Neuroendocrine studies of the aetiology of puerperal psychosis. Clin Neuropharmacol 15:212–213

    Article  Google Scholar 

  • Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240:889–895

    Article  CAS  PubMed  Google Scholar 

  • Flood JF, Smith GE, Roberts E (1988) Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res 447:269–278

    Article  CAS  PubMed  Google Scholar 

  • Friess E, Trachsel L, Guldner J et al (1995) DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. Am J Physiol 268:E107–E113

    CAS  PubMed  Google Scholar 

  • Friess E, Tagaya H, Trachsel L et al (1997) Progesterone-induced changes in sleep in male subjects. Am J Physiol 272:E885–E891

    CAS  PubMed  Google Scholar 

  • Ghadirian AM, Engelsmann F, Dhar V et al (1995) The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment. Biol Psychiatry 37:369–375

    Article  CAS  PubMed  Google Scholar 

  • Gold PW, Loriaux DL, Roy A et al (1986) Responses to corticotropin-releasing hormone in the hypercortisolism of depression and Cushing’s disease. N Engl J Med 314:1329–1335

    Article  CAS  PubMed  Google Scholar 

  • Gregoire AJP, Kumar R, Everitt B et al (1996) Transdermal oestrogen for treatment of severe postnatal depression. Lancet 347:930–933

    Article  CAS  PubMed  Google Scholar 

  • Häfner H, Nowotny B (1995) Epidemiology of early-onset schizophrenia. Eur Arch Psychiatry Clin Neurosci 245:80–92

    Article  PubMed  Google Scholar 

  • Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23:477–501

    Article  CAS  PubMed  Google Scholar 

  • Holsboer F, Barden N (1996) Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 17:187–205

    Article  CAS  PubMed  Google Scholar 

  • Holsboer F, von Bardeleben U, Gerken A et al (1984) Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. N Engl J Med 311:1127

    CAS  PubMed  Google Scholar 

  • Hudson JI, Hudson MS (1984) Endocrine dysfunction in anorexia nervosa and bulimia: comparison with abnormalities in other psychiatric disorders and disturbances due to metabolic factors. Psychiatr Dev 2:237–272

    CAS  PubMed  Google Scholar 

  • Ising M, Lucae S, Binder EB et al (2009) A genomewide association study points to multiple loci that predict antidepressant treatment response. Arch Gen Psychiatry 66:966–975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jahn H, Schick M, Kiefer F et al (2004) Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry 61:1235–1244

    Article  CAS  PubMed  Google Scholar 

  • Kellner M, Herzog L, Yassouridis A et al (1995) Possible role of atrial natriuretic hormoe in pituitary adrenocortical unresponsiveness in lactate-induced panic. Am J Psychiatry 152:1365–1367

    Article  CAS  PubMed  Google Scholar 

  • Krieg J-C, Lauer CJ, Hermle L et al (1990) Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders. Neuropsychobiology 23:57–67

    Article  CAS  PubMed  Google Scholar 

  • Kulkarni J, Riedel A, de Castella AR et al (2001) Estrogen – a potential treatment for schizophrenia. Schizophr Res 48:137–144

    Article  CAS  PubMed  Google Scholar 

  • Kulkarni J, Gavrilidis E, Wang W, Worsley R, Fitzgerald PB, Gurvich C, van Rheenen T, Berk M, Burger H (2015) Estradiol for treatment-resistant schizohprehnia: a large-scale randomized-controlled trial in women of child-bearing age. Mol Psychiatry 20:695–702

    Google Scholar 

  • Lancel M, Faulhaber J, Holsboer F, Rupprecht R (1996) Progesterone induces changes in sleep EEG comparable to those of agonistic GABAA receptor modulators. Am J Physiol 271:E763–E772

    Article  CAS  PubMed  Google Scholar 

  • Lesch KP, Rupprecht R (1989) Psychoneuroendocrine research in depression: II. Hormonal responses to releasing hormones as a probe for hypothalamic-pituitary-endorgan dysfunction. J Neural Transm 75:179–194

    Article  CAS  PubMed  Google Scholar 

  • Lesch KP, Ihl R, Frölich L et al (1990) Endocrine responses to growth hormone releasing hormone and corticotropin releasing hormone in early onset Alzheimer’s disease. Psychiatry Res 33:107–112

    Article  CAS  PubMed  Google Scholar 

  • Murphy BEP, Dhar V, Ghadirian AM et al (1991) Response to steroid suppression in major depression resistant to antidepressant therapy. J Clin Psychopharmacol 11:121–126

    CAS  PubMed  Google Scholar 

  • Nemeroff CB, Widerlöv E, Bisette G et al (1984) Elevated concentrations of CSF corticotropin-releasing-factor-like immunoreactivity in depressed patients. Science 226:1342–1343

    Article  CAS  PubMed  Google Scholar 

  • Neuhauser H, Laakmann G (1988) Stimulation of growth hormone by GHRH as compared to DMI in depressed patients. Pharmacopsychiatry 21:443–444

    Article  CAS  PubMed  Google Scholar 

  • O’Dwyer A-M, Lightman SL, Marks MN, Checkley SA (1995) Treatment of major depression with metyrapone and hydrocortisone. J Affect Disord 33:123–128

    Article  PubMed  Google Scholar 

  • Paul SM, Purdy RH (1992) Neuroactive steroids. FASEB J 6:2311–2322

    Article  CAS  PubMed  Google Scholar 

  • Rao ML, Strebel B, Halaris A et al (1995) Circadian rhythm of vital signs, norepinephrine, epinephrine, thyroid hormones, and cortisol in schizophrenia. Psychiatry Res 57:21–39

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R (1997) The neuropsychopharmacological potential of neuroactive steroids. J Psychiatr Res 31(3):297–314

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R (2003) Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties. Psychoneuroendocrinology 28:139–168

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Lesch KP (1989) Psychoneuroendocrine research in depression: I. Hormone levels of different neuroendocrine axes and the dexamethasone suppression test. J Neural Transm 75:167–178

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Lesch KP, Müller U et al (1989a) Blunted adrenocorticotropin but normal beta-endorphin release after human corticotropin-releasing hormone administration in depression. J Clin Endocrinol Metab 69:600–603

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Rupprecht C, Rupprecht M et al (1989b) Triiodothyronine, thyroxine and TSH response to dexamethasone in depressed patients and normal controls. Biol Psychiatry 25:22–32

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Baghai TC, Möller HJ (2004) Neuentwicklungen in der Pharmakotherapie der Depression. Nervenarzt 75:273–280

    Article  CAS  PubMed  Google Scholar 

  • Rupprecht R, Rammes G, Eser D et al (2009) Translocator protein (18 kDa) as target for anxiolytics without benzodiazepine-like side effects. Science 325:490–493

    Article  CAS  PubMed  Google Scholar 

  • Schatzberg AF (2015) The role of the hypothalamic-pituitary-adrenal (HPA) axis in the pathogenesis of psychotic major depression. World J Biol Psyhciatry 16:2–11

    Article  Google Scholar 

  • Schreiber W, Lauer CJ, Krumrey K et al (1996) Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder. Neuropsychopharmacology 15:7–15

    Article  CAS  PubMed  Google Scholar 

  • Schüle C, Baghai TC, Eser D et al (2009a) The combined dexamethasone/CRH test (DEX/CRH test) and prediction of acute treatment response in major depression. PLoS One 4:e4324

    Article  PubMed  PubMed Central  Google Scholar 

  • Schüle C, Baghai TC, Eser D, Rupprecht R (2009b) Hypothalamic-pituitary-adrenocortical (HPA) system regulation and new treatment strategies in depression. Exp Rev Neurother 9:1005–1019

    Article  Google Scholar 

  • Starkmann MN, Schteingart DE (1981) Neuropsychiatric manifestations of patients with Cushing’s syndrome. Relationship to cortisol and adrenocorticotropic hormone levels. Arch Intern Med 141:215–219

    Article  Google Scholar 

  • Steiger A (1995) Schlafendokrinologie. Nervenarzt 66:15–27

    CAS  PubMed  Google Scholar 

  • Steiger A, Guldner J, Colla-Müller M et al (1994) Growth hormone-releasing hormone (GHRH)-induced effects on sleep EEG and nocturnal secretion of growth hormone, cortisol and ACTH in patients with major depression. Psychiatr Res 28:225–238

    Article  CAS  Google Scholar 

  • Unden F, Ljunggren JG, Kjellman BF et al (1986) Twenty-four-hour serum levels and decreased TSH response to TRH in affective disorders. Acta Psychiatr Scand 73:358–365

    Article  CAS  PubMed  Google Scholar 

  • Voderholzer U, Laakmann G, Wittman R et al (1993) Profiles of spontaneous 24-hour and stimulated growth hormone secretion in male patients with endogenous depression. Psychiatry Res 47:215–227

    Article  CAS  PubMed  Google Scholar 

  • von Bardeleben U, Stalla GK, Müller OA, Holsboer F (1988) Blunting of corticotropin response to corticotropin-releasing hormone in depressed patients is avoided by metyrapone pretreatment. Biol Psychiatry 24:782–786

    Article  Google Scholar 

  • Wolkowitz OM, Reus VI, Manfredi F et al (1993) Ketoconazole administration in hypercortisolemic depression. Am J Psychiatry 150:810–812

    Article  CAS  PubMed  Google Scholar 

  • Zobel AW, Yassouridis A, Frieboes RM, Holsboer F (1999) Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am J Psychiatry 156:949–951

    Article  CAS  PubMed  Google Scholar 

  • Zobel AW, Nickel T, Kunzel HE et al (2000) Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res 34:171–181

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg, Bezirksklinikum Regensburg, Universitätsstr 84, 93053, Regensburg, Deutschland

    Rainer Rupprecht

Authors
  1. Rainer Rupprecht
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rainer Rupprecht .

Editor information

Editors and Affiliations

  1. em. Direktor der Klinik für Psychiatrie und Psychotherapie, der Ludwig-Maximilians-Universität (LMU) München, München, Germany

    Hans-Jürgen Möller

  2. Ehem. Ärztlicher Direktor des kbo-Inn-Salzach-Klinikums für Psychiatrie, Psychotherapie, Psychosomatik und Neurologie, Akadem. Lehrkrankenhaus der LMU München Institut für Psychologische Medizin (IPM), Soyen, Germany

    Gerd Laux

  3. Vorstand der Klinik für Psychiatrie und Psychotherapeutische Medizin, Medizinische Universität Graz, Graz, Austria

    Hans-Peter Kapfhammer

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag GmbH Deutschland

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Rupprecht, R. (2017). Psychoneuroendokrinologische Grundlagen psychischer Erkrankungen. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie, Psychosomatik, Psychotherapie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49295-6_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-49295-6_9

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-49293-2

  • Online ISBN: 978-3-662-49295-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation