Zusammenfassung
In diesem Kapitel werden zum einen die Grundlagen der klinischen Prüfung von Psychopharmaka, v. a. betreffend Studiendesign und statistischer Auswertemethoden, dargestellt. Besonderen Wert wird auch auf das neue Gebiet der Metaanalysen gelegt. Zum anderen werden die großen Substanzklassen dargestellt, sodass der Leser einen Überblick über die unterschiedlichen psychopharmakologischen Behandlungsoptionen erhält. Hierbei wird auf eine umfassende Darstellung Wert gelegt.
Literatur
Al-Sukhni M, Maruschak NA, McIntyre RS (2015) Vortioxetine: a review of efficacy, safety and tolerability with a focus on cognitive symptoms in major depressive disorder. Expert Opin Drug Saf 14:1291–1304
American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists, North American Association of the Study of Obesity (2004) Consensus development conference on antipsychotic drugs and obesity and diabetes. J Clin Psychiatry 65:267–272
Anderson IM, Tomenson BM (1994) The efficacy of selective serotonin re-uptake inhibitors in depression: a meta-analysis of studies against tricyclic antidepressants. J Psychopharmacol 8:238–249
Andreasen NC (1984a) Scale for the Assessment of Negative Symptoms (SANS). University of Iowa, Iowa City
Andreasen NC (1984b) Scale for the Assessment of Positive Symptoms (SAPS). University of Iowa, Iowa City
Ashton H. Benzodiazepine Wirkungsweise und therapeutischer Entzug. Überarbeitete Fassung 2002. http://www.benzo.org.uk/german/bzcha01.htm#8. Zugegriffen am 19.08.2013
Auguet M, Clostre F, De Feudis FV (1986) Effects of antidepressants on receptor-activated and Ca2+− activated contractions of rabbit isolated aorta. Gen Pharmacol 17:607–610
Baastrup PC, Poulsen JC, Schou M et al (1970) Prophylactic lithium: double blind discontinuation in manic-depressive and recurrent-depressive disorders. Lancet 15:326–330
Baldwin DS, Loft H, Dragheim M (2012) A randomised, double-blind, placebo controlled, duloxetine-referenced, fixed-dose study of three dosages of Lu AA21004 in acute treatment of major depressive disorder (MDD). Eur Neuropsychopharmacol 22:482–491
Bauer M, Tharmanathan P, Volz HP et al (2009) The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression: a meta-analysis. Eur Arch Psychiatry Clin Neurosci 259:172–185
Bauer M, Pfennig A, Severus E et al (2013) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders. World J Biol Psychiatry 14:334–385
Bech P (1978) Depressive symptomatology and drug response. Commun Psychopharmacol 2:409–418
Benkert O, Hippius H (2014) Kompendium der psychiatrischen Pharmakotherapie, 10. Aufl. Springer, Berlin/Heidelberg
Birks J, Harvey RJ (2006) Donepezil for dementia due to Alzheimer’s disease. Cochrane Database Syst Rev (1):CD001190.
Birks JS, Chong LY, Grimley Evans J (2015) Rivastigmine for Alzheimer’s disease. Cochrane Database Syst Rev. Sep 22;9:CD001191
Borbely AA, Mattmann P, Loepfe M et al (1985) Effect of benzodiazepine hypnotics on all-night sleep EEG spectra. Hum Neurobiol 4:189–194
Boulenger JP, Loft H, Flora I (2012) A randomized clinical study of Lu AA21004 in the prevention of relapse in patients with major depressive disorder. Psychopharmacology 26:1408–1416
Bowden CL, Calabrese JR, McElroy SL et al (2000) A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group. Arch Gen Psychiatry 57:481–489
Bowden CL, Calabrese JR, Sachs G (2003) A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 60:392–400
Braquet P (1987) The ginkgolides: potent platelet-activating factor antagonists’ isolated from Ginkgo biloba L. chemistry, pharmacology and clinical applications. Drugs Fut 12:643–699
Brondino N, De Silvestri A, Re S (2013) A systematic review and meta-analysis of Ginkgo biloba in neuropsychiatric disorders: from ancient tradition to modern-day medicine. Evid Based Complement Alternat Med 2013:915691
Calabrese JR, Bowden CL, Sachs G et al (2003) A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 64:1013–1024
Calabrese JR, Goldberg JF, Ketter TA et al (2006) Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies. Biol Psychiatry 59:1061–1064
Castells X, Ramos-Quiroga JA, Bosch R et al (2011a) Amphetamines for Attention Deficit Hyperactivity Disorder (ADHD) in adults. Cochrane Database Syst Rev (6):CD007813
Castells X, Ramos-Quiroga JA, Rigau D et al (2011b) Efficacy of methylphenidate for adults with attention-deficit hyperactivity disorder: a meta-regression analysis. CNS Drugs 25:157–169
Cipriani A, Furukawa TA, Geddes JR et al (2009) Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet 373:746–758
CIPS, Collegium Internationale Psychiatriae Scalarum (Hrsg) (2015) Internationale Skalen für Psychiatrie. Hogrefe, Göttingen
Cross National Collaborative Panic Study (1992) Drug treatment of panic disorder. Comparative efficacy of alprazolam, imipramine, and placebo. Cross-National Collaborative Panic Study, Second Phase Investigators. Drug treatment of panic disorder. Comparative efficacy of alprazolam, imipramine, and placebo. Br J Psychiatry 160:191–202
Cunill R, Castells X, Tobias A et al (2013) Atomoxetine for attention deficit hyperactivity disorder in the adulthood: a meta-analysis and meta-regression. Pharmacoepidemiol Drug Saf 22:961–969
Cunill R, Castells X, Tobias A et al (2016) Efficacy safety and variability in pharmacotherapy for adults with attention deficit hyperactivity disorder: a meta-analysis and meta-regression in over 9000 patients. Psychopharmacology (Berl) 233:187–197
Davis JM, Schaffer CB, Killian GA et al (1980) Important issues in the drug treatment of schizophrenia. Schizophr Bull 6:70–87
DGPPN, BÄK, KBV et al (Hrsg) (2015) S3-Leitlinie/Nationale Versorgungsleitlinie Unipolare Depression, 2. Aufl.
Doogan DP, Caillard V (1992) Sertraline in the prevention of depression. Br J Psychiatry 160:217–222
Downing RW, Rickels K (1985) Early treatment response in anxious outpatients treated with diazepam. Acta Psychiatr Scand 72:522–528
Du J, Gray NA, Falke C et al (2003) Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression. Ann N Y Acad Sci 1003:378–380
Faraone SV, Glatt SJ (2010) A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes. J Clin Psychiatry 71:754–763
Farrimond L, Roberts E, McShane R (2012) Memantine and cholinesterase inhibitor combination therapy for Alzheimer’s disease: a systematic review. BMI Open 2, e000917
Frank E, Kupfer DJ, Perel JM et al (1990) Three-year outcomes for maintenance therapies in recurrent depression. Arch Gen Psychiatry 47:1093–1099
Fritz RR, Malek-Ahmadi P et al (1983) Tranylcypromine lowers human platelet MAO B activity but not concentration. Biol Psychiatry 18:685–694
Gentil V, Alevizos B, Felix-Gentil M et al (1978) Single-dose effects of tranylcypromine on psychophysiological measures in normals. Br J Clin Pharmacol 5:536–538
Gianoulakis C (2004) Endogenous opioids and addiction to alcohol and other drugs of abuse. Curr Top Med Chem 4:39–50
Goodwin GM, Bowden CL, Calabrese JR et al (2004) A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 65:432–441
Graham J, Banaschewski T, Buitelaar J et al (2011) European guidelines on managing adverse effects of medication for ADHD. Eur Child Adolesc Psychiatry 20:17–37
Greil W, Kleindienst N (1999a) The comparative prophylactic efficacy of lithium and carbamazepine in patients with bipolar I disorder. Int Clin Psychopharmacol 14:277–281
Greil W, Kleindienst N (1999b) Lithium versus carbamazepine in the maintenance treatment of bipolar II disorder and bipolar disorder not otherwise specified. Int Clin Psychopharmacol 14:283–285
Greil W, Ludwig-Mayerhofer W, Erazo N et al (1997) Lithium versus carbamazepine in the maintenance treatment of bipolar disorders-a randomised study. J Affect Disord 43:151–161
Grunze H, Bauer M (2012) Medikamente zur Behandlung bipolar affektiver Störungen. In: Gründer G, Benkert O (Hrsg) Handbuch der psychiatrischen Pharmakotherapie, 2. Aufl. Springer, Berlin, S 629–657
Grunze H, Vieta E, Goodwin GM et al (2013) The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of bipolar disorders: update 2012 on the long-term treatment of bipolar disorder. World J Biol Psychiatry 14:154–219
Gual A, He Y, Torup L, van den Brink W et al (2013) A randomised, double-blind, placebo-controlled, efficacy study of nalmefene, as-needed use, in patients with alcohol dependence. Eur Neuropsychopharmacol 23:1432–1442
Hajak G, Müller WE, Wittchen HU et al (2003) Abuse and dependence potential for the nonbenzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data. Addiction 98:1371–1378
Hasan A, Falkai P, Wobrock T et al (2012) World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance. World J Biol Psychiatry 13:318–378
Hatta K, Sato K, Hamakawa H et al (2009) Effectiveness of second-generation antipsychotics with acute-phase schizophrenia. Schizophrenia Res 113:49–55
Hazell PL, Kohn MR, Dickson R et al (2011) Core ADHD symptom improvement with atomoxetine versus methylphenidate: a direct comparison meta-analysis. J Atten Disord 15:674–683
Heuser I, Förstl H (2012) Antidementiva. In: Gründer G, Benkert O (Hrsg) Handbuch der psychiatrischen Pharmakotherapie, 2. Aufl. Springer, Berlin, S 713–731
Howard R, McShane R, Lindesay J et al (2012) Donepezil and memantine for moderate-to-severe Alzheimer’s disease. N Engl J Med 366:893–903
Huedo-Medina TB, Kirsch I, Middlemass J et al (2012) Effektiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration. BMJ 345. doi:10.1136/bmj.e8343
Ihl R, Frölich L, Winblad B et al (2011) World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of Alzheimer’s disease and other dementias. World J Biol Psychiatry 12:2–32
Janssens D, Michiels C, Delaive E et al (1995) Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and Bilobalide. Biochem Pharmacol 50:991–999
Janssens D, Remacle J, Drieu K et al (1999) Protection of mitochondrial respiration activity by Bilobalide. Biochem Pharmacol 58:109–119
Janssens D, Delaive E, Remacle J et al (2000) Protection by bilobalide of the ischaemia-induced alterations of the mitochondrial respiratory activity. Fundam Clin Pharmacol 14:193–201
Kane JM, Woerner M, Borenstein M et al (1986) Integrating incidence and prevalence of tardive dyskinesia. Psychopharmacol Bull 22:254–258
Kasper S, Buchkremer G, Dilling H et al (Hrsg) (1994) Depressive Storungen erkennen und behandeln. Karger, Basel Freiburg
Kasper S, Möller HJ (2011) Psychopharmakotherapie – Klinisch-empirische Grundlagen. In: Möller HJ, Laux G, Kapfhammer HP (Hrsg) Psychiatrie, Psychosomatik, Psychotherapie, Bd 1, 4. Aufl. Springer, Heidelberg, S 731–766
Kasper S, Olié JP (2002) A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression. Eur Psychiatry 17(Suppl 3):331–340
Katona C, Hansen T, Olsen CK (2012) A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int Clin Psychopharmacol 27:215–223
Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276
Keller MB, Trivedi MH, Thase ME (2007a) The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the acute and continuation phases. Biol Psychiatry 62:1371–1379
Keller MB, Trivedi MH, Thase ME et al (2007b) The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) study: outcomes from the 2-year and combined maintenance phases. J Clin Psychiatry 68:1246–1256
Kiefer F, Mann K (2010) Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy. Curr Pharm Des 16:2098–2102
Kiefer F, Soyka M (2012) Medikamente zur Behandlung von Abhängigkeit und Entzugssymptomen. In: Gründer G, Benkert O (Hrsg) Handbuch der psychiatrischen Pharmakotherapie, 2. Aufl. Springer, Berlin, S 733–7491
Kishimoto T, Robenzadeh A, Leucht C et al (2014) Long-acting injectable vs oral antipsychotics for relapse prevention in schizophrenia: a meta-analysis of randomized trials. Schizophr Bull 40:192–213
Kissling W (1991) Guidelines for neuroleptic relapse prevention in schizophrenia. Springer, Berlin/Heidelberg/New York
Kocsis JH, Thase ME, Trivedi MH et al (2007) Preventention of recurrent episodes of depression with venlafaxine ER in a 1-year maintenance phase from the PREVENT study. J Clin Psychiatry 68:1014–1023
Koesters M, Becker T, Kilian R et al (2009) Limits of meta-analysis: methylphenidate in the treatment of adult attention-deficit hyperactivity disorder. J Psychopharmacol 23:733–744
Kraus JE, Sheitman BB, Cook A et al (2005) Olanzapine versus risperidone in newly admitted acutely ill psychotic patients. J Clin Psychiatry 66:1564–1568
Kupfer DJ (1991) Lessons to be learned from long-term treatment of aff ective disorders: Potential utility in panic disorder. J Clin Psychiatry 52 (Suppl 2): 12–16
Lang F, Hoerr R, Noeldner M et al (2013) Ginkgo biloba extract EGb 761: from an ancient Asian plant to a modern European herbal medicine product. In: Wagner H, Ulrich-Merzenich G (Hrsg) Evidence and rational based research on Chinese drugs. Springer, Wien, S 431–470
Lau J, Ioannidis JPA, Schmid CH (1997) Quantitative synthesis in systematic reviews. Ann Intern Med 127:820–826
Laux G, Ulrich S (2006) Tranylcypromin. PPT 13:130–144
Laux G, VIVALDI Study Group (2012) The antidepressant agomelatine in daily practice: results of the non-interventional study VIVALDI. Pharmacopsychiatry 45:284–291
Laux G, Becker T, Müller U (2002) Indikationen (von Tranylcypromin). In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka. Ein Therapiehandbuch, Bd 3, Antidepressiva, Phasenprophylaktika und Stimmungsstabilisierer. Springer, Wien/New York, S 489–507
Laux G, Huttner NA, VIVALDI Study Group (2014) Subgroup analysis of the non-interventional study VIVALDI: agomelatine in treatment-naïve patients, in combination therapy and after treatment switch. Int J Psychiatry Clin Pract 18:86–96
Leucht S, Barnes TR, Kissling W et al (2003) Relapse prevention in schizophrenia with new-generation antipsychotics: a systematic review and exploratory meta-analysis of randomized, controlled trials. Am J Psychiatry 160:1209–1222
Leucht S, Corves C, Arbter D et al (2009) Second generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373:31–41
Leucht S, Cipriani A, Spineli L et al (2013) Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet 282:951–962
Linde K, Mulrow CD, Berner M et al (2005) St John’s wort for depression. Cochrane Database Syst Rev (2)
Lockhart IA, Mitchell SA, Kelly S (2009) Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer’s disease: systematic review of the ‚real-world‘ evidence. Dement Geriatr Cogn Disord 28:389–403
Loy C, Schneider L (2006) Galantamine for Alzheimer’s disease and mild cognitive impairment. Cochrane Database Syst Rev 1, CD001747
Mahableshwarkar AR, Zajecka J, Jacobson W et al (2015) A randomized, placebo-controlled, active-reference, double-blind, flexible-dose study of the efficacy of vortioxetine on cognitive function in major depressive disorder. Neuropsychopharmacology 8:2025–2037
Maneeton N, Maneeton B, Eurviriyanukul K et al (2013) Efficacy, tolerability, and acceptability of bupropion for major depressive disorder: a meta-analysis of randomized-controlled trials comparison with venlafaxine. Drug Des Devel Ther 7:1053–1062
Mann K, Bladström A, Torup L (2013) Extending the treatment options in alcohol dependence: a randomized controlled study of as-needed nalmefene. Biol Psychiatry 73:706–713
McCue R, Waheed R, Urcuyo L et al (2006) Comparative effectiveness of second-generation antipsychotics and haloperidol in acute schizophrenia. Brit J Psychiatry 189:433–440
McShane R, Areosa Sastre A, Minakaran N (2006) Memantine for dementia. Cochrane Database Syst Rev. Apr 19;(2):CD003154
Meeker AS, Herink MC, Haxby DG et al (2015) The safety and efficacy of vortioxetine for acute treatment of major depressive disorder: a systematic review and meta-analysis. Syst Rev 4:21
Mészáros A, Czobor P, Bálint S et al (2009) Pharmacotherapy of adult attention deficit hyperactivity disorder (ADHD): a meta-analysis. Int J Neuropsychopharmacol 12:1137–1147
Miguel-Hidalgo JJ, Alvarez XA, Cacabelos R et al (2002) Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1–40). Brain Res 958:210–221
Möller HJ (1990) Neuroleptische Langzeittherapie schizophrener Erkrankungen. In: Heinrich K (Hrsg) Leitlinien neuroleptischer Therapie. Springer, Berlin/Heidelberg/New York, S 97–115
Möller HJ (2001) Amisulpride: efficacy in the management of chronic patients with predominant negative symptoms. Eur Arch Psychiatry Clin Neurosci 251:217–224
Möller HJ (2004) Novel antipsychotics in the long-term treatment of schizophrenia. World J Biol Psychiatry 5:9–19
Murphy BP, Chung YC, Park TW et al (2006) Pharmacological treatment of primary negative symptoms in schizophrenia: a systematic review. Schizophr Res 88:5–25
Neuvonen PJ, Pohjola-Sintonen S, Tacke U et al (1993) Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses. Lancet 342:1419
NICE (National Institute for Clinical Excellence) (2003) Core interventions in the treatment of schizophrenia. NICE, London. www.nice.org.uk
Nissen C, Frase L, Hajak G, Wetter TC (2014) Hypnotika – Stand der Forschung. Nervenarzt 85:67–76
Nutt DJ (2009) Beyond psychoanaleptics – can we improve antidepressant drug nomenclature? J Psychopharmacol 23:343–345
O’Donnell T, Rotzinger S, Nakashima TT et al (2003) Chronic lithium and sodium valproate both decrease the concentration of myoinositol and increase the concentration of inositol monophosphates in rat brain. Eur Neuropsychopharmacol 13:199–207
Overall JE, Gorham DR (1962) The brief psychiatric rating scale. Psychol Rep 10:799–812
Papakostas GI, Fava M (2006) A metaanalysis of clinical trials comparing moclobemide with selective serotonin reuptake inhibitors for the treatment of major depressive disorder. Can J Psychiatry 51:783–790
Papakostas GI, Stahl SM, Krishen A et al (2008) Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of major depressive disorder with high levels of anxiety (anxious depression): a pooled analysis of 10 studies. J Clin Psychiatry 69:1287–1292
Peuskens J, Trivedi J, Malyarov S (2007) Prevention of schizophrenia relapse extended release quetiapine fumarate dosed once daily: a randomized, placebo-controlled trial in clinically stable patients. Psychiatry 4:34–50
Porter AMW (1970) Depressive illness in a general practice. A demographic study and a controlled trial of imipramine. BMJ 1:773–778
Prien RF, Caffey EM Jr, Klett CJ (1973) Prophylactic efficacy of lithium carbonate in manic-depressive illness. Report of the Veterans Administration and National Institute of Mental Health Collaborative Study Group. Arch Gen Psychiatry 28:337–341
Prien RF, Klett CJ, Caffey EM Jr (1974) Lithium prophylaxis in recurrent affective illness. Am J Psychiatry 131:198–203
Prien RF, Kupfer DJ, Mansky PA et al (1984) Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium carbonate-imipramine combination. Arch Gen Psychiatry 41:1096–1104
Raja M, Azzoni A (2003) Comparison of three antipsychotics in the emergency psychiatric setting. Hum Psychopharmacol 18:447–452
Rapaport MH, Bose A, Zheng (2004) Escitalopram continuation treatment prevents relapse of depressive episodes. J Clin Psychiatry 65:44–49
Reimherr FW, Byerley WF, Ward MF et al (1988) Sertraline, a selective inhibitor of serotonin uptake, for the treatment of outpatients with major depressive disorder. Psychopharmacol Bull 24:200–205
Rösner S, Leucht S, Lehert P et al (2008) Acamprosate supports abstinence, naltrexone prevents excessive drinking: evidence from a meta-analysis with unreported outcomes. J Psychopharmacol 22:11–23
Rösner S, Hackl-Herrwerth A, Leucht S (2010a) Acamprosate for alcohol dependence. Cochrane Database Syst Rev (9):CD004332
Rösner S, Hackl-Herrwerth A, Leucht S (2010b) Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev (12):CD001867
Rummel-Kluge C, Kissling W, Leucht S (2006) Antidepressants for the negative symptoms of schizophrenia. Cochrane Database Syst Rev (3), Art. No.: CD005581. doi:10.1002/14651858.CD005581.pub2
Schäfer I, Lambert M, Naber D (2004) Atypische Antipsychotika bei therapieresistenter Schizophrenie. Nervenarzt 75:79–91
Schatzberg AF, Cole JO (1978) Benzodiazepines in depressive disorders. Arch Gen Psychiatry 35:1359–1365
Soyka M (2014) Nalmefene for the treatment of alcohol dependence: a current update. Int J Neuropsychopharmacol 17:675–684
Storebø OJ, Krogh HB, Ramstad E et al (2015) Methylphenidate for attention-deficit/hyperactivity disorder in children and adolescents: Cochrane systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. BMJ 351:h5203
Stuhec M, Munda B, Svab V et al (2015) Comparative efficacy and acceptability of atomoxetine, lisdexamfetamine, bupropion and methylphenidate in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis with focus on bupropion. J Affect Disord 178:149–159
Taylor DM, Duncan-McConnell D (2000) Refractory schizophrenia and atypical antipsychotics. J Psychopharmacol 14:409–418
Taylor D, Sparshatt A, Varma S et al (2014) Antidepressant efficacy of agomelatine: meta-analysis of published and unpublished studies. BMJ 348. doi:10.1136/bmj.g1888
Tiihonen J, Haukka J, Taylor M et al (2011) A nationwide cohort study of oral and depot antipsychotics after first hospitalization for schizophrenia. Am J Psychiatry 168:603–609
Treuer T, Gau SS, Méndez L et al (2013) A systematic review of combination therapy with stimulants and atomoxetine for attention-deficit/hyperactivity disorder, including patient characteristics, treatment strategies, effectiveness, and tolerability. J Child Adolesc Psychopharmacol 23:179–193
Tuunainen A, Wahlbeck K, Gilbody S (2002) Newer atypical antipsychotic medication in comparison to clozapine: a systematic review of randomized trials. Schizophr Res 56:1–10
van den Brink W, Aubin HJ, Bladström A et al (2013) Efficacy of as-needed nalmefene in alcohol-dependent patients with at least a high drinking risk level: results from a subgroup analysis of two randomized controlled 6-month studies. Alcohol Alcohol 48:570–578
van den Brink W, Sørensen P, Torup L et al (2014) Long-term efficacy, tolerability and safety of nalmefene as-needed in patients with alcohol dependence: a 1-year, randomised controlled study. J Psychopharmacol 28:733–744
van Laar T, De Deyn PP, Aarsland D et al (2011) Effects of cholinesterase inhibitors in Parkinson’s disease dementia: a review of clinical data. CNS Neurosci Ther 17:428–441
Vestergaard P, Gram LF, Kragh-Sørensen P et al (1993) Therapeutic potentials of recently introduced antidepressants. Danish University Antidepressant Group. Psychopharmacol Ser 10:190–198
Viguera AC, Koukopoulos A, Muzina DJ et al (2007) Teratogenicity and anticonvulsants: lessons from neurology to psychiatry. J Clin Psychiatry 68(Suppl 9):29–33
Volz HP, Ugur T (2014) Antidepressiva. In: Kasper S, Volz HP (Hrsg) Psychiatrie und Psychotherapie compact, 3. Aufl. Thieme, Stuttgart, S 306–330
Volz HP, Gleiter CH, Möller HJ (1996) Monoaminoxidasehemmer in der Psychiatrie. Nervenarzt 67:339–347
Volz HP, Reischies F, Riedel M (2010) Kognitive Störungen bei schizophrenen Patienten. Nervenarzt 81:39–54
Wahlbeck K, Cheine M, Essali A et al (1999) Evidence of clozapine’s effectiveness in schizophrenia: a systematic review and meta-analysis of randomised trials. Am J Psychiatry 156:990–999
Warner MD, Peabody CA, Whiteford HA et al (1988) Alprazolam as an antidepressant. J Clin Psychiatry 49:148–150
Watanabe N, Omori IM, Nakagawa A et al (2011) Mirtazapine versus other antidepressive agents for depression. Cochrane Database Syst Rev (12):CD006528
Weinmann S, Roll S, Schwarzbach C et al (2010) Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr 10:14
Weisler RH, Nolen WA, Neijber A et al (2011) Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: a randomized controlled study). J Clin Psychiatry 72:1452–1464
Woodward ND, Purdon SE, Meltzer HY (2005) A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. Int J Neuropsychopharmacol 8:457–472
Zimbroff DL, Kane JM, Tamminga CA et al (1997) Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group. Am J Psychiatry 154:782–791
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Volz, HP., Kasper, S., Möller, HJ. (2017). Psychopharmakotherapie – klinisch-empirische Grundlagen. In: Möller, HJ., Laux, G., Kapfhammer, HP. (eds) Psychiatrie, Psychosomatik, Psychotherapie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49295-6_31
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