Advertisement

Effect of Vasomotion on Blood Flow Distribution in Microvessels

  • J. C. Shao
  • Y. LiuEmail author
  • Z. D. Su
Conference paper
Part of the Lecture Notes in Mechanical Engineering book series (LNME)

Abstract

The control of flow in the microcirculation is crucial to ensure blood supply to the tissues. The spontaneous time-dependent contraction and relaxation of small arteries and arterioles was observed 160 years ago and is termed as vasomotion. Vasomotion is an intrinsic phenomenon unrelated to cardiac rhythm or neural and hormonal regulation; and it works as a local control mechanism to regulate the microvascular blood flow. In spite of tremendous studies on vasomotion, the physiological role of vasomotion is not clear. Vasomotion results in the flow oscillation which is termed as flowmotion. The flowmotion is crucial for optimal blood flow and nutrient delivery in micro vasculature. Blood vessels in tumors are highly irregular and dense compared to those in normal tissue which may affect the flowmotion. As the first attempt, in this study we investigated the effect of irregular microvascular structure on flow delivery in microvascular bed with composite flow oscillating frequencies. The results showed that the irregular micro vasculature would decrease the flowmotion and lead to reduction of nutrient and drug delivery which is consistent with the experimental observation.

Keywords

Vascular Network Tumor Vasculature Flow Oscillation Nutrient Delivery Intravital Microscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Support given by Hong Kong RGC under grant No. PolyU 5202/13E is gratefully acknowledged.

References

  1. Guo P, Fu BM (2012) Effect of wall compliance and permeability on blood-flow rate in counter-current microvessels formed from anastomosis during tumor-induced angiogenesis. J Biomech Eng 134(4):041003CrossRefGoogle Scholar
  2. Pries AR, Hopfner M, le Nobel F, Dewhirst MW, Secomb TW (2010) The shunt problem: control of functional shunting in normal and tumor vasculature. Nat Rev Cancer 10:587–593CrossRefGoogle Scholar
  3. Rossi M, Carpi A (2004) Skin microcirculation in peripheral arterial obliterative disease. Biomed Pharmacother 58:427–431CrossRefGoogle Scholar
  4. Segal SS (2000) Integration of blood flow control to skeletal muscle: key role of feed arteries. Acta Physiol Scand 168:511–518CrossRefGoogle Scholar
  5. Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49(23):6449–6465Google Scholar
  6. Zamir M (2005) The physics of coronary blood flow. Springer, New YorkzbMATHGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Mechanical EngineeringThe Hong Kong Polytechnic UniversityHong KongChina
  2. 2.College of Metrological and Measurement EngineeringChina Jiliang UniversityHangzhouChina

Personalised recommendations