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Radiochemie/Tracer

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PET/CT-Atlas

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Zusammenfassung

Die Positronenemissionstomographie (PET), als funktionell-diagnostisches Verfahren, ermöglicht eine hochauflösende, quantitative und sensitive molekulare Bildgebung. Die Visualisierung biologischer Prozesse erfolgt hierbei mittels radioaktiv markierter Verbindungen, deren effiziente Synthese essenziell für eine Anwendung in der klinischen Diagnostik ist. Im Rahmen dieses Kapitels werden daher die Produktionsrouten relevanter Radioisotope und die verschiedenen Markierungsstrategien für die einzelnen Nuklide näher beleuchtet. Dabei wird sowohl auf die »organischen« Radionuklide, wie z. B. Kohlenstoff-11 oder Fluor-18, als auch auf die »metallischen« Radionuklide, wie z. B. Gallium-68 oder Rubidium-82, eingegangen. Zudem werden auch die wichtigsten klinischen Tracer, wie z. B. 2-[18F]FDG oder [18F]FMISO, und ihre Darstellung erläutert.

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  1. Institut für Kernchemie, Johannes Gutenberg-Universität Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz

    Prof. Dr. rer. nat. Frank Rösch & Dr. med. Markus Piel

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    Heinrich Schelbert

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Rösch, F., Piel, M. (2016). Radiochemie/Tracer. In: Mohnike, W., Hör, G., Hertel, A., Schelbert, H. (eds) PET/CT-Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48842-3_3

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