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PET/CT in der Strahlentherapie

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PET/CT-Atlas

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Zusammenfassung

Die Strahlentherapie ist neben Chemotherapie und Operation elementarer Baustein für die Behandlung onkologischer Patienten. In den letzten Jahren hat sich diese erheblich gewandelt: Mit modernen Konzepten bietet sie sowohl eine Steigerung der Tumorkontrolle als auch eine Reduzierung von Nebenwirkungen. Dies wird v. a. erreicht durch die Anwendung der IMRT und deren Innovationen mit VMAT und Tomotherapie. Die Anwendung hochpräziser Bestrahlungstechniken setzt jedoch voraus, dass eine ebenso exakte Information zur Tumorausbreitung vorliegt. Die Verknüpfung der CT-Planung mit MRT und PET hat hier eine neue Grundlage geschaffen. Zusätzlich zur technischen Einbindung der CT-basierten Hybridbildgebung erlauben die aktuellen Entwicklungen in der molekularen Bildgebung über FDG hinaus mit immer spezifischeren Tracern (PSMA-Ligand, FET, F-MISO) die unmittelbare Integration von Tumorbiologie einschließlich Hypoxie und Proliferation in die Bestrahlungsplanung. Dieser Artikel stellt die Grundlagen sowie die praktische Umsetzung in den Einrichtungen der Autoren dar.

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Authors and Affiliations

  1. Diagnostisch Therapeutisches Zentrum, Kadiner Straße 23, 10243, Berlin

    Dr. med. Matthias Lampe

  2. Klinik für Strahlentherapie, HELIOS Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125, Berlin

    Prof. Dr. med. Robert Krempien

  3. Klinik für Strahlentherapie und Radioonkologie, Katharinenhospital, Klinikum Stuttgart, Kriegsbergstraße 60, 70174, Stuttgart

    Prof. Dr. med. Marc Münter

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  1. Dr. med. Matthias Lampe
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  2. Prof. Dr. med. Robert Krempien
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  1. Diagnostisch Therapeutisches Zentrum, Berlin, Deutschland

    Wolfgang Mohnike

  2. Königstein, Deutschland

    Gustav Hör

  3. Klinikum für Nuklearmedizin, Klinikum Fulda, Fulda, Deutschland

    Andreas Hertel

  4. UCLA Molecular & Medical Pharmacology, Los Angeles, CA, USA

    Heinrich Schelbert

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Lampe, M., Krempien, R., Münter, M. (2016). PET/CT in der Strahlentherapie. In: Mohnike, W., Hör, G., Hertel, A., Schelbert, H. (eds) PET/CT-Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48842-3_19

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