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Glomeruläre Erkrankungen

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Book cover Nierenerkrankungen im Kindes- und Jugendalter

Zusammenfassung

Dieses Kapitel stellt, orientiert an klinischen Leitsymptomen, die sich bei glomerulären Erkrankungen als nephritisches oder nephrotisches Syndrom bzw. einem Mischbild zeigen, entsprechende Erkrankungen mit ihren Spezifika im Kindesalter dar. Die Möglichkeiten und Erkenntnisse genetischer Diagnostik und deren Bedeutung für die Therapie werden repetitiv aufgegriffen. Ebenso wird die Bedeutung des Komplementsystems als primärer Auslöser sowie sekundärer Aktivator glomerulärer Erkrankungen dargestellt.

Die Original-Version dieses Kapitels wurde korrigiert. http://dx.doi.org/10.1007/978-3-662-48789-1_19

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Notes

  1. 1.

    Von: Anja K. Büscher, Stefanie Weber

  2. 2.

    Von Martin Pohl

Literatur

  • Arbeitsgemeinschaft für Pädiatrische Nephrologie (APN) (2007) Therapieempfehlung zur Lupusnephritis bei Kindern und Jugendlichen. Monatsschr Kinderheilkd 155: 1175–1188

    Google Scholar 

  • Benz MR, Ehren R, Tönshoff V, Weber LT (2015) Alternativen zur Steroidbehandlung des steroidsensiblen nephrotischen Syndroms im Kindesalter. Nephrologe 10: 462–470

    Google Scholar 

  • Benz MR, Reiter K, Eife R (2004) Hämaturie und Proteinurie im Kindesalter. Monatsschr. Kinderheilkd 152: 238–247

    Google Scholar 

  • Benz MR, Weber LT (2012) Nephrotisches Syndrom im Kindesalter. Monatsschr Kinderheilkd 160: 787–804

    Google Scholar 

  • Cossey LN, Walker PD, Larsen CP (2013) Phospholipase A2 receptor staining in pediatric idiopathic membranous glomerulopathy. Pediatr Nephrol 28: 2307–2311

    Google Scholar 

  • Cugno M, Castelli R, Cicardi M (2008) Angioedema due to acquired C1-inhibitor deficiency: a bridging condition between autoimmunity and lymphoproliferation. Autoimmunity reviews 8: 156–159

    Google Scholar 

  • Fries JW, Mendrick DL, Rennke HG (1988) Determinants of immune complex-mediated glomerulonephritis. Kidney Int 34: 333

    Google Scholar 

  • Gardner-Medwin JM, Dolezalova P, Cummins C, Southwood TR (2002) Incidence of Henoch-Schonlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet 360: 1197–1202

    Google Scholar 

  • Gbadegesin R, Smoyer WE (2008) Nephrotic Syndrome. In: Geary DF, Schaefer F (eds) Comprehensive Pediatric Nephrology. Mosby Elsevier, Philadelphia

    Google Scholar 

  • Habbig S, Mihatsch MJ, Heinen S et al. (2009) C3 deposition glomerulopathy due to a functional factor H defect. Kidney international 75: 1230–1234

    Google Scholar 

  • Hagelberg S, Lee Y, Bargman J et al. (2002) Longterm Followup of Childhood Lupus Nephritis. J Rheumatol 29: 2635–2642

    Google Scholar 

  • Hanly JG, O’Keeffe AG, Su L et al. (2016) The frequency and outcome of lupus nephritis: results from an international inception cohort study. Rheumatology 55: 252–262

    Google Scholar 

  • KDIGO Clinical Practice Guideline for Glomerulonephritis (2012) Idiopathic membranous nephropathy. Kidney International Supplements 2: 186–197

    Google Scholar 

  • KDIGO Glomerulonephritis Work Group (2012) KDIGO clinical practice guideline for glomerulonephritis. Kidney Int Suppl 2: 139–274

    Google Scholar 

  • Legendre CM, Licht C, Muus P et al. (2013) Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med 368 2169–2181

    Google Scholar 

  • Lemaire M, Fremeaux-Bacchi V, Schaefer F et al. (2013) Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nat Genet 45: 531–536

    Google Scholar 

  • Livingston B, Bonner A, Pope J (2011) Differences in clinical manifestations between childhood-onset lupus and adult-onset lupus: a meta-analysis. Lupus 20: 1345–1355

    Google Scholar 

  • Loirat C, Fakhouri F, Ariceta G et al. for HUSI (2016) An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatric nephrology 31: 15–39

    Google Scholar 

  • Loirat C, Fremeaux-Bacchi V (2011) Atypical hemolytic uremic syndrome. Orphanet J Rare Dis 6: 60

    Google Scholar 

  • Mahler M, van Schaarenburg RA, Trouw LA (2013) Anti-C1q autoantibodies, novel tests, and clinical consequences. Frontiers in immunology 4: 117

    Google Scholar 

  • McCaffrey J, Lennon R, Webb NJA (2015) The non-immunosuppressive management of childhood nephrotic syndrome. Pediatr Nephrol: http://link.springer.com/article/10.1007%2Fs00467-015-3241-0. Letzter Zugriff: 26.04.2016

    Google Scholar 

  • Mekahli D, Liutkus A, Ranchin B et al. (2009) Long-term outcome of idiopathic steroid-resistant nephrotic syndrome: a multicenter study. Pediatr Nephrol 24: 1525–1532

    Google Scholar 

  • Menon S, Valentini RP (2010) Membranous nephropathy in children: clinical presentation and therapeutic approach. Pediatr Nephrol 25: 1419–1428

    Google Scholar 

  • Mestecky J, Raska M, Julian BA et al. (2013) IgA Nephropathy: Molecular Mechanisms of the Disease Annu Rev Pathol Mech Dis 8: 217–240

    Google Scholar 

  • Michael M, Elliott EJ, Craig JC, Ridley G, Hodson EM (2009) Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials. Am J Kidney Dis 53: 259–272

    Google Scholar 

  • Mollnes TE, Kirschfink M (2006) Complement analysis in clinic and research. Advances in experimental medicine and biology 586: 361–380

    Google Scholar 

  • Narchi H (2005) Risk of long term renal impairment and duration of follow up recommended for Henoch-Schonlein purpura with normal or minimal urinary findings: a systematic review. Arch Dis Child 90: 916–920

    Google Scholar 

  • Niaudet P (2008) Nephritic Syndrome. In: Geary DF, Schaefer F (eds) Comprehensive Pediatric Nehrology. Mosby, Philadelphia

    Google Scholar 

  • Noris M, Remuzzi G (2013) Overview of complement activation and regulation. Seminars in nephrology 33: 479–492

    Google Scholar 

  • Pohl M, DittrichK, Ehrich JHH et al; Gesellschaft für Pädiatrische Nephrologie (2013) Behandlung der Purpura-Schönlein-Henoch-Nephritis bei Kindern und Jugendlichen – Therapieempfehlungen der Gesellschaft für Pädiatrische Nephrologie (GPN). Monatsschr Kinderheilkd 161: 543–553

    Google Scholar 

  • Pons-Estel GJ, Alarcon GS, McGwin G Jr et al. (2009) Protective effect of hydroxychloroquine on renal damage in patients with lupus nephritis: LXV, data from a multiethnic US cohort. Arthritis Rheum 61: 830–839

    Google Scholar 

  • Ponticelli C, Moroni M, Glassock RJ (2014) De Novo Glomerular Diseases after Renal Transplantation. Clin J Am Soc Nephrol 9: 1479–1487

    Google Scholar 

  • Potter EV, Lipschultz SA, Abidh S, et al. (1982)Twelve to seventeen-year follow-up of patients with poststreptococcal acute glomerulonephritis in Trinidad. N Engl J Med 307: 725

    Google Scholar 

  • Riedl M, Fakhouri F, Lequintrec M et al. (2014) The spectrum of complement-mediated thrombotic microangiopathies: pathogenetic insights identifying novel treatment approaches. Semin Thromb Hemost 40: 444–464

    Google Scholar 

  • Roberts IS, Cook HT, Troyanov S et al; Working Group of the International IgA Nephropathy Network and the Renal Pathology Society (2009) The Oxford classification of IgA nephropathy: pathology definitions, correlations, and reproducibility. Kidney Int 76: 546–556

    Google Scholar 

  • Rodriguez-Iturbe B, Batsford S (2007) Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet. Kidney Int 71: 1094

    Google Scholar 

  • Rodriguez-Iturbe B, Musser JM (2008) The current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol 19: 1855

    Google Scholar 

  • Ronco P, Debiec H (2015) Pathophysiological advances in membranous nephropathy: time for a shift in patient’s care. Lancet 385: 1983–1992

    Google Scholar 

  • Rosales A, Hofer J, Zimmerhackl LB et al. for the German-Austrian HUSSG (2012) Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae. Clin Infect Dis 54: 1413–1421

    Google Scholar 

  • Rosenecker J (2014) Pädiatrische Differenzialdiagnostik. Springer, Berlin Heidelberg

    Google Scholar 

  • Roy S 3rd, Murphy WM, Arant BS Jr. (1981) Poststreptococcal crescentic glomerulonephritis in children: comparison of quintuple therapy versus supportive care. J Pediatr 98: 403

    Google Scholar 

  • Ruggenenti P, Debiec H, Ruggiero B et al. (2015) Anti-phospholipase A2 receptor antibody titer predicts post-rituximab outcome ofmembranous nephropathy. J Am Soc Nephrol 26: 2545–2558

    Google Scholar 

  • Samuel S, Bitzan M, Zappitelli M et al. (2014) Canadian Society of Nephrology Commentary oft he 2012 KDIGO Clinical Practice Guideline for Glomerulonephritis: Management of Nephrotic Syndrome in Children. Am J Kidney Dis 63: 354–362

    Google Scholar 

  • Schärer K, Mehls O (2002) Pädiatrische Nephrologie. Springer, Berlin Heidelberg

    Google Scholar 

  • Servais A, Noel LH, Roumenina LT et al. (2012) Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies. Kidney international 82: 454–464

    Google Scholar 

  • Siddall EC, Radhakrishnan J (2012) The pathophysiology of edema formation in the nephrotic syndrome. Kidney International 82: 635–642

    Google Scholar 

  • Troyanov S, Wall CA, Miller JA, Scholey JW, Cattran DC; Toronto Glomerulonephritis Registry Group (2004) Idiopathic membranous nephropathy: definition and relevance of a partial remission. Kidney Int 66: 1199–1205

    Google Scholar 

  • Vivarelli M, Emma F (2014) Treatment of C3G with complement blockers. Semin Thromb Hemost 40: 472–477

    Google Scholar 

  • Weening JJ, D’Agati VD, Schwartz MM et al. (2004) International Society of Nephrology Working Group on the Classification of Lupus Nephritis; Renal Pathology Society Working Group on the Classification of Lupus Nephritis: The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 65: 521–530

    Google Scholar 

  • Wilhelmus S, Bajema IM, Bertsias GK et al. (2015) Lupus nephritis management guidelines compared. Nephrol Dial Transplant (online first): 10.1093/ndt/gfv102

    Google Scholar 

  • Wuerzner R, Riedl M, Rosales A, Orth-Hoeller D (2014) Treatment of enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome. Semin Thromb Hemost 40: 508–516

    Google Scholar 

  • Zuber J, Fakhouri F, Roumenina LT, Loirat C, Fremeaux-Bacchi V (2012) Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies. Nature Reviews Nephrology 8: 643–657

    Google Scholar 

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Author information

Authors and Affiliations

  1. Nephropathologische Abteilung, Universitätsklinikum Erlangen, Krankenhausstraße 8–10, 91054, Erlangen

    Prof. Dr. med Kerstin Amann

  2. Klinik für Kinderheilkunde II Kindernephrologie, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen

    PD Dr. med. Anja K. Büscher

  3. Division of Nephrology, The Hospital for Sick Children, University Avenue 555, M5G 1X8, ON, Toronto, Canada

    Prof. Dr. med. Christoph Licht

  4. Klinik für Allgemeine Kinder- und Jugendmedizin Kindernephrologie, Universitätsklinikum Freiburg, Mathildenstr. 1, 79106, Freiburg

    PD Dr. med. Martin Pohl

  5. Research Institute, The Hospital for Sick Children Cell Biology Program, University Avenue 555, M5G 1X8, ON, Toronto, Canada

    Dr. med. Magdalena Riedl

  6. Klinik für Kinder- und Jugendmedizin II Kindernephrologie, Universitätsklinikum Gießen und Marburg, Standort Marburg, Baldingerstraße, 35033, Marburg

    Prof. Dr. med. Stefanie Weber

  7. Klinik und Poliklinik für Kinder- und Jugendmedizin Kindernephrologie, Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln

    Prof. Dr. med. Lutz T. Weber

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  1. Prof. Dr. med Kerstin Amann
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Editors and Affiliations

  1. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Köln, Köln

    Jörg Dötsch  & Lutz T. Weber  & 

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Amann, K. et al. (2017). Glomeruläre Erkrankungen. In: Dötsch, J., Weber, L. (eds) Nierenerkrankungen im Kindes- und Jugendalter. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48789-1_2

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  • DOI: https://doi.org/10.1007/978-3-662-48789-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-48788-4

  • Online ISBN: 978-3-662-48789-1

  • eBook Packages: Medicine (German Language)

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