Skip to main content

Pain Management

  • Chapter
  • First Online:
The Surgery of Childhood Tumors
  • 1365 Accesses

Abstract

It is one of the “Rights of the Child” not to have to endure pain [1, 2]. In the past there was little knowledge or understanding of pain in children [3]. Many of us were taught that babies do not feel pain. Minor operations such as circumcision were often performed on neonates with no analgesia. We now know this to be a cruel misconception and in fact neonates have an enhanced, more global response to pain. Sensitization of the nervous system by trauma at such an early age can lead to different pain behavior in later life [4]. This global response in neonates is due in part to the poor hyalinization of nerves at this early stage of life, and also to the inability to localize pain until the brain develops a proper body image in the first few months of life.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Southall DP, et al. The Child-Friendly Healthcare Initiative (CFHI): healthcare provision in accordance with the UN Convention on the Rights of the Child. Pediatrics. 2000;106(5):1054–64.

    Article  CAS  PubMed  Google Scholar 

  2. http://www.childfriendlyhealthcare.org/publications/pediatrics.htm.

  3. Bonica JJ. Evolution and current status of pain programs. J Pain Symptom Manage. 1990;5(6):368–74 (review).

    Article  CAS  PubMed  Google Scholar 

  4. Taddio A, Katz J. The effects of early pain experience in neonates on pain responses in infancy and childhood. Paediatr Drugs. 2005;7(4):245–57 (review).

    Article  PubMed  Google Scholar 

  5. Franck LS, Greenberg CS, Stevens B. Pain assessment in infants and children. In: Yaster M, editor. The pediatric clinics of North America. Philadelphia: Lippincott; 2000. p. 487–512.

    Google Scholar 

  6. Bonica JJ. The management of pain, vol. 1. 2nd ed. Pennsylvania: Lea and Febiger; 1990.

    Google Scholar 

  7. Fitzgerald M, Howard RF. The neurobiologic basis of pediatric pain. In: Schecter NL, Berde CB, Yaster M, editors. Pain in infants, children and adolescents. 2nd ed. Philadelphia: Lippincott; 2003. p. 19–42.

    Google Scholar 

  8. Hu P, McLachlan EM. Long-term changes in the distribution of galanin in dorsal root ganglia after sciatic or spinal nerve transection in rats. Neuroscience. 2001;103(4):1059–71.

    Article  CAS  PubMed  Google Scholar 

  9. Bago M, Dean C. Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT(1A) receptors in the RVLM. Am J Physiol Regul Integr Comp Physiol. 2001;280(4):R976–84.

    CAS  PubMed  Google Scholar 

  10. Holmberg K, Shi TJ, Albers KM, Davis BM, Hokfelt T. Effect of peripheral nerve lesion and lumbar sympathectomy on peptide regulation in dorsal root ganglia in the NGF-overexpressing mouse. Exp Neurol. 2001;167(2):290–303.

    Article  CAS  PubMed  Google Scholar 

  11. Scislo TJ, Kitchen AM, Augustyniak RA, O’Leary DS. Differential patterns of sympathetic responses to selective stimulation of nucleus tractus solitarius purinergic receptor subtypes. Clin Exp Pharmacol Physiol. 2001;28(1–2):120–4 (review).

    Article  CAS  PubMed  Google Scholar 

  12. Chabal C. Membrane stabilizing agents and experimental neuromas. In: Fields HL, Liebeskind JC, editors. Pharmacological approaches to the treatment of chronic pain: new concepts and critical issues, Progress in pain research and management, vol. 1. Seattle: IASP Press; 1994. p. 205–10.

    Google Scholar 

  13. Halligan PW, Zeman A, Berger A. Phantoms in the brain. Question the assumption that the adult brain is “hard wired.”. BMJ. 1999;319(7210):587–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Centre for Synaptic Plasticity. http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html.

  15. Dev KK, Henley JM. The regulation of AMPA receptor-binding sites. Mol Neurobiol. 1998;17(1–3):33–58.

    Article  CAS  PubMed  Google Scholar 

  16. Parpura V, Basarsky TA, Liu F, Jeftinija K, Jeftinija S, Haydon PG. Glutamate-mediated astrocyte-neuron signalling. Nature. 1994;369(6483):707–8.

    Article  Google Scholar 

  17. Dendorfer A, Wolfrum S, Dominiak P. Pharmacology and cardiovascular implications of the kinin-kallikrein system. Jpn J Pharmacol. 1999;79:403–26.

    Article  CAS  PubMed  Google Scholar 

  18. Skidgel RA, Alhenc-Gelas F, Campbell WB. Relation of cardiovascular signaling by kinins and products of similar converting enzyme systems; prologue: kinins and related systems. New life for old discoveries. Am J Physiol Heart Circ Physiol. 2003;284:H1886–91.

    Article  CAS  PubMed  Google Scholar 

  19. Dendorfer A, Wolfrum S, Wagemann M, Qadri F, Dominiak P. Pathways of bradykinin degradation in blood and plasma of normotensive and hypertensive rats. Am J Physiol Heart Circ Physiol. 2001;280:H2182–8.

    CAS  PubMed  Google Scholar 

  20. Kuoppala A, Lindstedt KA, Saarinen J, Kovanen PT, Kokkonen JO. Inactivation of bradykinin by angiotensin-converting enzyme and by carboxypeptidase N in human plasma. Am J Physiol Heart Circ Physiol. 2000;278(4):H1069–74.

    CAS  PubMed  Google Scholar 

  21. Kozlowska M, Smolenski RT, Makarewicz W, Hoffmann C, Jastorff B, Swierczynski J. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171–81.

    Article  CAS  PubMed  Google Scholar 

  22. Kondo M, Yamaoka T, Honda S, et al. The rate of cell growth is regulated by purine biosynthesis via ATP production and G1 to S phase transition 1. J Biochem. 2000;128(1):57–64.

    Article  CAS  PubMed  Google Scholar 

  23. Yegutkin GG, Samburski SS, Jalkanen S. Soluble purine-converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactions. FASEB J. 2003;17(10):1328–30. Epub 2003 May 20.

    CAS  PubMed  Google Scholar 

  24. Schurmann M, Gradl G, Wizgal I, Tutic M, Moser C, Azad S, Beyer A. Clinical and physiologic evaluation of stellate ganglion blockade for complex regional pain syndrome type I. Clin J Pain. 2001;17(1):94–100.

    Article  CAS  PubMed  Google Scholar 

  25. Cleary AG, Sills JA, Davidson JE, Cohen AM. Reflex sympathetic dystrophy. Rheumatology (Oxford). 2001;40(5):590–1.

    Article  CAS  Google Scholar 

  26. Ceballos A, Cabezudo L, Bovaira M, Fenollosa P, Moro B. Spinal cord stimulation: a possible therapeutic alternative for chronic mesenteric ischaemia. Pain. 2000;87(1):99–101.

    Article  CAS  PubMed  Google Scholar 

  27. McCleane G. Pharmacological strategies in relieving neuropathic pain. Expert Opin Pharmacother. 2004;5(6):1299–312.

    Article  CAS  PubMed  Google Scholar 

  28. Manning DC. New and emerging pharmacological targets for neuropathic pain. Curr Pain Headache Rep. 2004;8(3):192–8.

    Article  PubMed  Google Scholar 

  29. Cousins MJ, Mather LE. Intrathecal and extradural administration of opioids. Anesthesiology. 1984;61:276–310.

    Article  CAS  PubMed  Google Scholar 

  30. Chaney MA. Side effects of intrathecal and extradural opiates. Can J Anaesth. 1995;42:891–903.

    Article  CAS  PubMed  Google Scholar 

  31. Lynch BA, Lambeng N, Nocka K, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci. 2004;101(26):9861–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Maihofner C, Handwerker HO, Neundorfer B, Birklein F. Patterns of cortical reorganisation in complex regional pain syndrome. Neurology. 2003;61(12):1707–15.

    Article  PubMed  Google Scholar 

  33. Buskila D, Neumann L, Press J. Genetic factors in neuromuscular pain. CNS Spectr. 2005;10(4):281–4.

    PubMed  Google Scholar 

  34. Finegold AA, Mannes AJ, Iadarola MJ. A paracrine paradigm for in vivo gene therapy in the central nervous system: treatment of chronic pain. Hum Gene Ther. 1999;10(7):1251–7.

    Article  CAS  PubMed  Google Scholar 

  35. Kaye P. Pocket book of symptom control. Northampton: EPL Publications; 1994. p. 72.

    Google Scholar 

  36. Smith O. Pain-killer genes. Science. 1999;284(5420):1634.

    Article  CAS  PubMed  Google Scholar 

  37. Currie JM. Management of chronic pain in children. Arch Dis Child. 2006;91:111–4.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John Currie .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Currie, J. (2016). Pain Management. In: Carachi, R., Grosfeld, J. (eds) The Surgery of Childhood Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48590-3_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-48590-3_39

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-48588-0

  • Online ISBN: 978-3-662-48590-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics