Lanthanide-Doped Upconversion Nanoparticles for Imaging-Guided Drug Delivery and Therapy

  • Zhanjun Li
  • Yuanwei Zhang
  • Gang HanEmail author
Part of the Springer Series in Biomaterials Science and Engineering book series (SSBSE, volume 6)


Lanthanide-doped upconversion nanoparticles (UCNPs) possess unique anti-Stokes optical properties, in which low-energy near-infrared (NIR) excitation can be converted into high-energy UV and/or visible emission with pronounced luminescence and chemical stability. Due to the rapid development of synthesis chemistry, lanthanide-doped UCNPs can be fabricated with narrow distribution and modulated physical behaviors. These unique characters endow them unique NIR-driven imaging/delivery/therapeutic applications, especially in the cases of the deep tissue environments. Herein, we introduce both the basic concepts and the up-to-date progresses of UCNPs in material engineering, toxicology, and bio-applications in imaging, molecular delivery, and tumor therapeutics.


Upconversion nanoparticles Optical imaging Drug delivery Optical therapy 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular PharmacologyUniversity of Massachusetts-Medical SchoolWorcesterUSA

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