Zusammenfassung
Die allergische bronchopulmonale Aspergillose ist eine seltene, oft spät diagnostizierte, allergische Erkrankung der Atemwege, die auf dem Boden eines Asthma bronchiale entsteht und durch eine komplexe Immunantwort auf A. fumigatus (oder seltener andere Pilze), die intrapulmonal gedeihen, zu schwerer, irreversibler Lungenschädigung führt. Die Diagnose lässt sich durch die Kombination typischer klinischer Zeichen, Laborparameter und Radiologie stellen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Agarwal R, Maskey D, Aggarwal AN et al (2013a) Diagnostic performance of various tests and criteria employed in allergic bronchopulmonary aspergillosis: a latent class analysis. PLoS One 8:e61105
Agarwal R, Chakrabarti A, Shah A et al (2013b) Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy 43:850–873
Agarwal R, Gupta D, Aggarwal AN et al (2010) Clinical significance of decline in serum IgE levels in allergic bronchopulmonary aspergillosis. Respir Med 104:204–210
Agarwal R, Aggarwal AN, Sehgal IS, Dhooria S, Behera D, Chakrabarti A (2015) Performance of serum galactomannan in patients with allergic bronchopulmonary aspergillosis. Mycoses 58(7):408–412
Bains SN, Judson MA (2012) Allergic bronchopulmonary aspergillosis. Clin Chest Med 33:265–281
Balter MS, Rebuck AS (1992) Treatment of allergic bronchopulmonary aspergillosis with inhaled corticosteroids. Respir Med 86:441–442
Beauvais A, Fontaine T, Aimanianda V, Latge JP (2014) Aspergillus cell wall and biofilm. Mycopathologia 178:371–377
Bedi RS (1994) Allergic bronchopulmonary aspergillosis: review of 20 cases. Indian J Chest Dis Allied Sci 36:181–186
Bellocchio S, Moretti S, Perruccio K et al (2004) TLRs govern neutrophil activity in aspergillosis. J Immunol 173:7406–7415
Bonini M, Di Maria G, Paggiaro P et al (2014) Potential benefit of omalizumab in respiratory diseases. Ann Allergy Asthma Immunol 113:513–519
Bosken CH, Myers JL, Greenberger PA, Katzenstein AL (1988) Pathologic features of allergic bronchopulmonary aspergillosis. Am J Surg Pathol 12:216–222
Chapman BJ, Capewell S, Gibson R, Greening AP, Crompton GK (1989) Pulmonary eosinophilia with and without allergic bronchopulmonary aspergillosis. Thorax 44:919–924
Chauhan B, Santiago L, Kirschmann DA et al (1997) The association of HLA-DR alleles and T cell activation with allergic bronchopulmonary aspergillosis. J Immunol 159:4072–4076
Chetty A (2003) Pathology of allergic bronchopulmonary aspergillosis. Front Biosci 8:e110–e114
Chowdhary A, Agarwal K, Kathuria S, Gaur SN, Randhawa HS, Meis JF (2014) Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview. Crit Rev Microbiol 40:30–48
Denning DW, O’Driscoll BR, Powell G et al (2009) Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med 179:11–18
Denning DW, Pleuvry A, Cole DC (2013) Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults. Med Mycol 51:361–370
Dhooria S, Agarwal R (2014) Diagnosis of allergic bronchopulmonary aspergillosis: a case-based approach. Future Microbiol 9:1195–1208
van der Ent CK, Hoekstra H, Rijkers GT (2007) Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. Thorax 62:276–277
Gauthier T, Wang X, Sifuentes Dos Santos J et al (2012) Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. PLoS One 7:e29906
Gibson PG, Wark PA, Simpson JL et al (2003) Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis. Eur Respir J 21:582–588
Graves TS, Fink JN, Patterson R, Kurup VP, Scanlon GT (1979) A familial occurrence of allergic bronchopulmonary aspergillosis. Ann Intern Med 91:378–382
Greenberger PA (1994) Diagnosis and management of allergic bronchopulmonary aspergillosis. Allergy Proc 15:335–339
Greenberger PA (2002) Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. Clin Allergy Immunol 16:449–468
Greenberger PA (2012) Chapter 18: Allergic bronchopulmonary aspergillosis. Allergy Asthma Proc 33:S61–S63 (Suppl 1)
Greenberger PA (1988) Allergic bronchopulmonary aspergillosis and fungoses. Clin Chest Med 9:599–608
Greenberger PA, Patterson R (1987) Allergic bronchopulmonary aspergillosis. Model of bronchopulmonary disease with defined serologic, radiologic, pathologic and clinical findings from asthma to fatal destructive lung disease. Chest 91:165S–171S
Greenberger PA, Patterson R (1988) Allergic bronchopulmonary aspergillosis and the evaluation of the patient with asthma. J Allergy Clin Immunol 81:646–650
Greenberger PA, Smith LJ, Hsu CC, Roberts M, Liotta JL (1988) Analysis of bronchoalveolar lavage in allergic bronchopulmonary aspergillosis: divergent responses of antigen-specific antibodies and total IgE. J Allergy Clin Immunol 82:164–170
Greenberger PA, Bush RK, Demain JG, Luong A, Slavin RG, Knutsen AP (2014) Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol Pract 2:703–708
Hansell DM, Strickland B (1989) High-resolution computed tomography in pulmonary cystic fibrosis. Br J Radiol 62:1–5
Hemmann S, Menz G, Ismail C, Blaser K, Crameri R (1999) Skin test reactivity to 2 recombinant Aspergillus fumigatus allergens in A fumigatus-sensitized asthmatic subjects allows diagnostic separation of allergic bronchopulmonary aspergillosis from fungal sensitization. J Allergy Clin Immunol 104:601–607
Henderson AH (1968) Allergic aspergillosis: review of 32 cases. Thorax 23:501–512
Heppt W, Bachert C (2010) Praktische Allergologie, 2. Aufl. Thieme, Stuttgart
Hinson KF, Moon AJ, Plummer NS (1952) Broncho-pulmonary aspergillosis; a review and a report of eight new cases. Thorax 7:317–333
Hogan C, Denning DW (2011) Allergic bronchopulmonary aspergillosis and related allergic syndromes. Semin Respir Crit Care Med 32:682–692
Howard SJ, Cerar D, Anderson MJ et al (2009) Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis 15:1068–1076
Imbeault B, Cormier Y (1993) Usefulness of inhaled high-dose corticosteroids in allergic bronchopulmonary aspergillosis. Chest 103:1614–1617
Kauffman HF, Beaumont F, de Monchy JG, Sluiter HJ, de Vries K (1984) Immunologic studies in bronchoalveolar fluid in a patient with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 74:835–840
Kaur S, Gupta VK, Thiel S, Sarma PU, Madan T (2007) Protective role of mannan-binding lectin in a murine model of invasive pulmonary aspergillosis. Clin Exp Immunol 148:382–389
Kirsten D, Nowak D, Rabe KF, Magnussen H (1993) Diagnosis of bronchopulmonary aspergillosis is often made too late. Med Klin (Munich) 88:353–356
Knutsen AP (2011) Immunopathology and immunogenetics of allergic bronchopulmonary aspergillosis. J Allergy (Cairo) 2011:785983
Kono Y, Tsushima K, Yamaguchi K et al (2013) The utility of galactomannan antigen in the bronchial washing and serum for diagnosing pulmonary aspergillosis. Respir Med 107:1094–1100
Logan PM, Muller NL (1996a) High-attenuation mucous plugging in allergic bronchopulmonary aspergillosis. Can Assoc Radiol J 47:374–377
Logan PM, Muller NL (1996b) CT manifestations of pulmonary aspergillosis. Crit Rev Diagn Imaging 37:1–37
Malo JL, Pepys J, Simon G (1977) Studies in chronic allergic bronchopulmonary aspergillosis. 2. radiological findings. Thorax 32:262–268
McCarthy DS, Pepys J (1971) Allergic broncho-pulmonary aspergillosis. Clinical immunology. 2. Skin, nasal and bronchial tests. Clin Allergy 1:415–432
McCarthy DS, Simon G, Hargreave FE (1970) The radiological appearances in allergic broncho-pulmonary aspergillosis. Clin Radiol 21:366–375
Mintzer RA, Rogers LF, Kruglik GD, Rosenberg M, Neiman HL, Patterson R (1978) The spectrum of radiologic findings in allergic bronchopulmonary aspergillosis. Radiology 127:301–307
Moss RB (2005) Pathophysiology and immunology of allergic bronchopulmonary aspergillosis. Med Mycol 43:S203–S206 (Suppl 1)
Moss RB (2014) Treatment options in severe fungal asthma and allergic bronchopulmonary aspergillosis. Eur Respir J 43:1487–1500
Murphy D, Lane DJ (1981) Pleural effusion in allergic bronchopulmonary aspergillosis: two case reports. Br J Dis Chest 75:91–95
Neeld DA, Goodman LR, Gurney JW, Greenberger PA, Fink JN (1990) Computerized tomography in the evaluation of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis 142:1200–1205
Panchal N, Pant C, Bhagat R, Shah A (1994) Central bronchiectasis in allergic bronchopulmonary aspergillosis: comparative evaluation of computed tomography of the thorax with bronchography. Eur Respir J 7:1290–1293
Panchal N, Bhagat R, Pant C, Shah A (1997) Allergic bronchopulmonary aspergillosis: the spectrum of computed tomography appearances. Respir Med 91:213–219
Pasqualotto AC, Denning DW (2007) Generic substitution of itraconazole resulting in sub-therapeutic levels and resistance. Int J Antimicrob Agents 30:93–94
Patterson K, Strek ME (2010) Allergic bronchopulmonary aspergillosis. Proc Am Thorac Soc 7:237–244
Patterson R, Greenberger PA, Halwig JM, Liotta JL, Roberts M (1986) Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies. Arch Intern Med 146:916–918
Phelan MS, Kerr IH (1984) Allergic broncho-pulmonary aspergillosis: the radiological appearance during long-term follow-up. Clin Radiol 35:385–392
Ricketti AJ, Greenberger PA, Patterson R (1984) Serum IgE as an important aid in management of allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 74:68–71
Ritz N, Ammann RA, Casaulta AC, Schoeni-Affolter F, Schoeni MH (2005) Risk factors for allergic bronchopulmonary aspergillosis and sensitisation to Aspergillus fumigatus in patients with cystic fibrosis. Eur J Pediatr 164:577–582
Rosenberg IL, Greenberger PA (1984) Allergic bronchopulmonary aspergillosis and aspergilloma. Long-term follow-up without enlargement of a large multiloculated cavity. Chest 85:123–125
Rosenberg M, Patterson R, Roberts M, Wang J (1978) The assessment of immunologic and clinical changes occurring during corticosteroid therapy for allergic bronchopulmonary aspergillosis. Am J Med 64:599–606
Saxena S, Madan T, Shah A, Muralidhar K, Sarma PU (2003) Association of polymorphisms in the collagen region of SP-A2 with increased levels of total IgE antibodies and eosinophilia in patients with allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 111:1001–1007
Schwartz HJ, Citron KM, Chester EH et al (1978) A comparison of the prevalence of sensitization to Aspergillus antigens among asthmatics in Cleveland and London. J Allergy Clin Immunol 62:9–14
Serisier DJ, Martin ML (2011) Long-term, low-dose erythromycin in bronchiectasis subjects with frequent infective exacerbations. Respir Med 105:946–949
Shah A, Panjabi C (2014) Allergic aspergillosis of the respiratory tract. Eur Respir Rev 23:8–29
Skov M, Pressler T, Jensen HE, Hoiby N, Koch C (1999) Specific IgG subclass antibody pattern to Aspergillus fumigatus in patients with cystic fibrosis with allergic bronchopulmonary aspergillosis (ABPA. Thorax 54:44–50
Stevens DA, Schwartz HJ, Lee JY et al (2000) A randomized trial of itraconazole in allergic bronchopulmonary aspergillosis. N Engl J Med 342:756–762
Tomee JF, Kauffman HF (2000) Putative virulence factors of Aspergillus fumigatus. Clin Exp Allergy 30:476–484
Tomee JF, Wierenga AT, Hiemstra PS, Kauffman HK (1997) Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines. J Infect Dis 176:300–303
Tomee JF, Kauffman HF, Klimp AH, de Monchy JG, Koeter GH, Dubois AE (1994) Immunologic significance of a collagen-derived culture filtrate containing proteolytic activity in Aspergillus-related diseases. J Allergy Clin Immunol 93:768–778
Virchow JC (2010) Allergische bronchopulmonale Aspergillose. In: Heppt W, Bachert C (Hrsg) Praktische Allergologie. Thieme, Stuttgart, S 56–64
Vlahakis NE, Aksamit TR (2001) Diagnosis and treatment of allergic bronchopulmonary aspergillosis. Mayo Clin Proc 76:930–938
Voskamp AL, Gillman A, Symons K et al (2015) Clinical efficacy and immunologic effects of omalizumab in allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol Pract 3:192–199
Webb W, Müller NL, Naidich DP (2009) High-resolution CT of the lung. Fourth. Aufl. Lipincott Williams & Wilkins, Philadelphia
Whitaker P, Brownlee K, Lee T, Conway S, Etherington C, Peckham D (2011) Sequential bronchoscopy in the management of lobar atelectasis secondary to allergic bronchopulmonary aspergillosis. J Bronchology Interv Pulmonol 18:57–60
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Virchow, J.C. (2016). Allergische bronchopulmonale Aspergillose. In: Kreuter, M., Costabel, U., Herth, F., Kirsten, D. (eds) Seltene Lungenerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48419-7_32
Download citation
DOI: https://doi.org/10.1007/978-3-662-48419-7_32
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-48418-0
Online ISBN: 978-3-662-48419-7
eBook Packages: Medicine (German Language)