Abstract
Acute pyogenic infections of the spine in pediatric age group are reviewed in this chapter. Spinal infections are uncommon in childhood; therefore, the clinical workup should begin with a high level of suspicion. Discitis and vertebral osteomyelitis have distinct epidemiologic, clinical, and radiographic features; however, they are considered to be different manifestations of the same pathological process. Child’s inability to communicate or localize symptoms and nonspecific laboratory findings generally cause a delay in the diagnosis that can be avoided with the early use of spinal imaging. Treatment should include intravenous antibiotics followed by oral intake, and rest and/or immobilization to improve comfort especially in the initial stages. Surgical interventions can occasionally be necessary especially in the setting of neurologic findings. The efficacy and duration of treatment can be followed via the levels of ESR and CRP. Functional deficits generally do not occur regardless of the radiological changes.
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Abbreviations
- CRP:
-
C-reactive protein
- ESR:
-
Erythrocyte sedimentation rate
- MRI:
-
Magnetic resonance imaging
- PCR:
-
Polymerase chain reaction
- PPD:
-
Purified protein derivative
References
Gouliouris T, Aliyu SH, Brown NM (2010) Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 65(Suppl 3):iii11–iii24
Fernandez M, Carrol CL, Baker CJ (2000) Discitis and vertebral osteomyelitis in children: an 18-year review. Pediatrics 105:1299–1304
van Dalen IV, Heeg M (2000) Neonatal infectious spondylitis of the cervical spine presenting with quadriplegia: a case report. Spine 25:1450–1452
Nussinovitch M, Sokolover N, Volovitz B, Amir J (2002) Neurologic abnormalities in children presenting with diskitis. Arch Pediatr Adolesc Med 156:1052–1054
Tomaszewski R, Bijata W (2011) Acute haematogenous upper cervical osteomyelitis in neonates: a report of two cases. J Bone Joint Surg 93:849–852
Kayser R, Mahlfeld K, Greulich M, Grasshoff H (2005) Spondylodiscitis in childhood: results of a long-term study. Spine 30:318–323
Early SD, Kay RM, Tolo VT (2003) Childhood diskitis. J Am Acad Orthop Surg 11:413–420
Cushing AH (1993) Diskitis in children. Clin Infect Dis 17:1–6
Brown R, Hussain M, McHugh K, Novelli V, Jones D (2001) Discitis in young children. J Bone Joint Surg 83:106–111
Spencer SJ, Wilson NI (2012) Childhood discitis in a regional children's hospital. J Pediatr Orthop B 21:264–268
Miranda I, Salom M, Burguet S (2014) Discitis en niños menores de 3 anõs. Serie de casos y revisión de la literatura. Rev Esp Cir Ortop Traumatol 58:92–100
Wenger DR, Bobechko WP, Gilday DL (1978) The spectrum of intervertebral disc-space infection in children. J Bone Joint Surg Am 60:100–108
Karabouta Z, Bisbinas I, Davidson A, Goldsworthy LL (2005) Discitis in toddlers: a case series and review. Acta Paediatr 94:1516–1518
Arthurs OJ, Gomez AC, Heinz P, Set PA (2009) The toddler refusing to weight-bear: a revised imaging guide from a case series. Emerg Med J 26:797–801
Menelaus MB (1964) Discitis. An inflammation affecting the intervertebral discs in children. J Bone Joint Surg Br 46:16–23
Spiegel PG, Kengla KW, Isaacson AS, Wilson JC Jr (1972) Intervertebral disc-space inflammation in children. J Bone Joint Surg Am 54:284–296
Kemp HB, Jackson JW, Jeremiah JD, Hall AJ (1973) Pyogenic infections occurring primarily in intervertebral discs. J Bone Joint Surg 55:698–714
Boston HC Jr, Bianco AJ Jr, Rhodes KH (1975) Disk space infections in children. Orthop Clin North Am 6:953–964
Fischer GW, Popich GA, Sullivan DE, Mayfield G, Mazat BA, Patterson PH (1978) Diskitis: a prospective diagnostic analysis. Pediatrics 62:543–548
Scoles PV, Quinn TP (1982) Intervertebral discitis in children and adolescents. Clin Orthop Relat Res 162:31–36
Crawford AH, Kucharzyk DW, Ruda R, Smitherman HC Jr (1991) Diskitis in children. Clin Orthop Relat Res 266:70–79
Jansen BR, Hart W, Schreuder O (1993) Discitis in childhood. 12-35-year follow-up of 35 patients. Acta Orthop Scand 64:33–36
Ryoppy S, Jaaskelainen J, Rapola J, Alberty A (1993) Nonspecific diskitis in children. A nonmicrobial disease? Clin Orthop Relat Res 297:95–99
Ring D, Johnston CE 2nd, Wenger DR (1995) Pyogenic infectious spondylitis in children: the convergence of discitis and vertebral osteomyelitis. J Pediatr Orthop 15:652–660
Ventura N, Gonzalez E, Terricabras L, Salvador A, Cabrera M (1996) Intervertebral discitis in children: a review of 12 cases. Int Orthop 20:32–34
Ceroni D, Cherkaoui A, Kaelin A, Schrenzel J (2010) Kingella kingae spondylodiscitis in young children: toward a new approach for bacteriological investigations? A preliminary report. J Child Orthop 4:173–175
Lew DP, Waldvogel FA (1997) Osteomyelitis. N Engl J Med 336:999–1007
Gutierrez K (2005) Bone and joint infections in children. Pediatr Clin North Am 52(779–794):vi
Fucs PM, Meves R, Yamada HH (2012) Spinal infections in children: a review. Int Orthop 36:387–395
Galil A, Gorodischer R, Bar-Ziv J, Hallel T, Malkin C, Garty R (1982) Intervertebral disc infection (discitis) in childhood. Eur J Pediatr 139:66–70
Wiley AM, Trueta J (1959) The vascular anatomy of the spine and its relationship to pyogenic vertebral osteomyelitis. J Bone Joint Surg 41-B:796–809
Whalen JL, Parke WW, Mazur JM, Stauffer ES (1985) The intrinsic vasculature of developing vertebral end plates and its nutritive significance to the intervertebral discs. J Pediatr Orthop 5:403–410
Song KS, Ogden JA, Ganey T, Guidera KJ (1997) Contiguous discitis and osteomyelitis in children. J Pediatr Orthop 17:470–477
Glazer PA, Hu SS (1996) Pediatric spinal infections. Orthop Clin North Am 27:111–123
Ratcliffe JF (1985) Anatomic basis for the pathogenesis and radiologic features of vertebral osteomyelitis and its differentiation from childhood discitis. A microarteriographic investigation. Acta Radiol Diagn (Stockh) 26:137–143
Garron E, Viehweger E, Launay F, Guillaume JM, Jouve JL, Bollini G (2002) Nontuberculous spondylodiscitis in children. J Pediatr Orthop 22:321–328
King HA (1999) Back pain in children. Orthop Clin North Am 30(467–474):ix
Dormans JP, Moroz L (2007) Infection and tumors of the spine in children. J Bone Joint Surg Am 89(Suppl 1):79–97
du Lac P, Panuel M, Devred P, Bollini G, Padovani J (1990) MRI of disc space infection in infants and children. Report of 12 cases. Pediatr Radiol 20:175–178
Maliner LI, Johnson DL (1997) Intervertebral disc space inflammation in children. Childs Nerv Syst 13:101–103; discussion 104
Sobottke R, Seifert H, Fatkenheuer G, Schmidt M, Gossmann A, Eysel P (2008) Current diagnosis and treatment of spondylodiscitis. Dtsch Arztebl Int 105:181–187
Rothman SL (1996) The diagnosis of infections of the spine by modern imaging techniques. Orthop Clin North Am 27:15–31
Chandrasenan J, Klezl Z, Bommireddy R, Calthorpe D (2011) Spondylodiscitis in children: a retrospective series. J Bone Joint Surg 93:1122–1125
Paushter DM, Modic MT, Masaryk TJ (1985) Magnetic resonance imaging of the spine: applications and limitations. Radiol Clin North Am 23:551–562
Digby JM, Kersley JB (1979) Pyogenic non-tuberculous spinal infection: an analysis of thirty cases. J Bone Joint Surg 61:47–55
Govender S (2005) Spinal infections. J Bone Joint Surg 87:1454–1458
Eismont FJ, Bohlman HH, Soni PL, Goldberg VM, Freehafer AA (1982) Vertebral osteomyelitis in infants. J Bone Joint Surg 64:32–35
Tsirikos AI, Tome-Bermejo F (2012) Spondylodiscitis in infancy: a potentially fatal condition that can lead to major spinal complications. J Bone Joint Surg 94:1399–1402
Reiss-Zimmermann M, Hirsch W, Schuster V, Wojan M, Sorge I (2010) Pyogenic osteomyelitis of the vertebral arch in children. J Pediatr Surg 45:1737–1740. doi:10.1016/j.jpedsurg.2010.04.010
Correa AG, Edwards MS, Baker CJ (1993) Vertebral osteomyelitis in children. Pediatr Infect Dis J 12:228–233
Buoncristiani AM, McCullen G, Shin AY, Bathgate B, Akbarnia BA (1998) An unusual cause of low back pain. Osteomyelitis of the spinous process. Spine 23:839–841
Skaf GS, Domloj NT, Fehlings MG, Bouclaous CH, Sabbagh AS, Kanafani ZA, Kanj SS (2010) Pyogenic spondylodiscitis: an overview. J Infect Public Health 3:5–16
Ananthakrishnan G, Wilkinson AG, McGurk SF, Marshall T (2009) Infantile chylothorax associated with staphylococcal paravertebral discitis. Pediatr Radiol 39:1354–1356
Robson JM, Harte GJ, Osborne DR, McCormack JG (1999) Cat-scratch disease with paravertebral mass and osteomyelitis. Clin Infect Dis 28:274–278
Abdel-Haq N, Abuhammour W, Al-Tatari H, Asmar B (2005) Disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess. South Med J 98:1142–1145
Tasher D, Armarnik E, Mizrahi A, Liat BS, Constantini S, Grisaru-Soen G (2009) Cat scratch disease with cervical vertebral osteomyelitis and spinal epidural abscess. Pediatr Infect Dis J 28:848–850
Modic MT, Pavlicek W, Weinstein MA, Boumphrey F, Ngo F, Hardy R, Duchesneau PM (1984) Magnetic resonance imaging of intervertebral disk disease. Clinical and pulse sequence considerations. Radiology 152:103–111
Dagirmanjian A, Schils J, McHenry M, Modic MT (1996) MR imaging of vertebral osteomyelitis revisited. AJR Am J Roentgenol 167:1539–1543
Pui MH, Mitha A, Rae WI, Corr P (2005) Diffusion-weighted magnetic resonance imaging of spinal infection and malignancy. J Neuroimaging 15:164–170
Post MJ, Bowen BC, Sze G (1991) Magnetic resonance imaging of spinal infection. Rheum Dis Clin North Am 17:773–794
Akhaddar A, Gourinda H, el Alami Z, el Madhi T, Miri A (1999) Hydatid cyst of the sacrum. Report of a case. Rev Rhum 66:289–291
Brook I (2001) Two cases of diskitis attributable to anaerobic bacteria in children. Pediatrics 107, E26
Trobs RB, Handrick W, Lotz I, Bankwitz C, Tannapfel A (2005) Vertebral osteomyelitis in an infant presenting with pseudotumor and narrowing of the spinal canal. Pediatr Surg Int 21:316–319
Rumana M, Mahadevan A, Nayil Khurshid M, Kovoor JM, Yasha TC, Santosh V, Indira B, Shankar SK (2006) Cestode parasitic infestation: intracranial and spinal hydatid disease–a clinicopathological study of 29 cases from South India. Clin Neuropathol 25:98–104
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Alanay, A., Yilgor, C. (2016). Acute Pediatric Spinal Infections. In: Akbarnia, B., Yazici, M., Thompson, G. (eds) The Growing Spine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48284-1_26
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DOI: https://doi.org/10.1007/978-3-662-48284-1_26
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