Skip to main content

Acute Pediatric Spinal Infections

  • Chapter
Book cover The Growing Spine

Abstract

Acute pyogenic infections of the spine in pediatric age group are reviewed in this chapter. Spinal infections are uncommon in childhood; therefore, the clinical workup should begin with a high level of suspicion. Discitis and vertebral osteomyelitis have distinct epidemiologic, clinical, and radiographic features; however, they are considered to be different manifestations of the same pathological process. Child’s inability to communicate or localize symptoms and nonspecific laboratory findings generally cause a delay in the diagnosis that can be avoided with the early use of spinal imaging. Treatment should include intravenous antibiotics followed by oral intake, and rest and/or immobilization to improve comfort especially in the initial stages. Surgical interventions can occasionally be necessary especially in the setting of neurologic findings. The efficacy and duration of treatment can be followed via the levels of ESR and CRP. Functional deficits generally do not occur regardless of the radiological changes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

CRP:

C-reactive protein

ESR:

Erythrocyte sedimentation rate

MRI:

Magnetic resonance imaging

PCR:

Polymerase chain reaction

PPD:

Purified protein derivative

References

  1. Gouliouris T, Aliyu SH, Brown NM (2010) Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother 65(Suppl 3):iii11–iii24

    CAS  PubMed  Google Scholar 

  2. Fernandez M, Carrol CL, Baker CJ (2000) Discitis and vertebral osteomyelitis in children: an 18-year review. Pediatrics 105:1299–1304

    Article  CAS  PubMed  Google Scholar 

  3. van Dalen IV, Heeg M (2000) Neonatal infectious spondylitis of the cervical spine presenting with quadriplegia: a case report. Spine 25:1450–1452

    Article  PubMed  Google Scholar 

  4. Nussinovitch M, Sokolover N, Volovitz B, Amir J (2002) Neurologic abnormalities in children presenting with diskitis. Arch Pediatr Adolesc Med 156:1052–1054

    Article  PubMed  Google Scholar 

  5. Tomaszewski R, Bijata W (2011) Acute haematogenous upper cervical osteomyelitis in neonates: a report of two cases. J Bone Joint Surg 93:849–852

    Article  CAS  Google Scholar 

  6. Kayser R, Mahlfeld K, Greulich M, Grasshoff H (2005) Spondylodiscitis in childhood: results of a long-term study. Spine 30:318–323

    Article  PubMed  Google Scholar 

  7. Early SD, Kay RM, Tolo VT (2003) Childhood diskitis. J Am Acad Orthop Surg 11:413–420

    PubMed  Google Scholar 

  8. Cushing AH (1993) Diskitis in children. Clin Infect Dis 17:1–6

    Article  CAS  PubMed  Google Scholar 

  9. Brown R, Hussain M, McHugh K, Novelli V, Jones D (2001) Discitis in young children. J Bone Joint Surg 83:106–111

    Article  CAS  Google Scholar 

  10. Spencer SJ, Wilson NI (2012) Childhood discitis in a regional children's hospital. J Pediatr Orthop B 21:264–268

    Article  PubMed  Google Scholar 

  11. Miranda I, Salom M, Burguet S (2014) Discitis en niños menores de 3 anõs. Serie de casos y revisión de la literatura. Rev Esp Cir Ortop Traumatol 58:92–100

    CAS  PubMed  Google Scholar 

  12. Wenger DR, Bobechko WP, Gilday DL (1978) The spectrum of intervertebral disc-space infection in children. J Bone Joint Surg Am 60:100–108

    CAS  PubMed  Google Scholar 

  13. Karabouta Z, Bisbinas I, Davidson A, Goldsworthy LL (2005) Discitis in toddlers: a case series and review. Acta Paediatr 94:1516–1518

    Article  PubMed  Google Scholar 

  14. Arthurs OJ, Gomez AC, Heinz P, Set PA (2009) The toddler refusing to weight-bear: a revised imaging guide from a case series. Emerg Med J 26:797–801

    Article  CAS  PubMed  Google Scholar 

  15. Menelaus MB (1964) Discitis. An inflammation affecting the intervertebral discs in children. J Bone Joint Surg Br 46:16–23

    CAS  PubMed  Google Scholar 

  16. Spiegel PG, Kengla KW, Isaacson AS, Wilson JC Jr (1972) Intervertebral disc-space inflammation in children. J Bone Joint Surg Am 54:284–296

    CAS  PubMed  Google Scholar 

  17. Kemp HB, Jackson JW, Jeremiah JD, Hall AJ (1973) Pyogenic infections occurring primarily in intervertebral discs. J Bone Joint Surg 55:698–714

    CAS  Google Scholar 

  18. Boston HC Jr, Bianco AJ Jr, Rhodes KH (1975) Disk space infections in children. Orthop Clin North Am 6:953–964

    PubMed  Google Scholar 

  19. Fischer GW, Popich GA, Sullivan DE, Mayfield G, Mazat BA, Patterson PH (1978) Diskitis: a prospective diagnostic analysis. Pediatrics 62:543–548

    CAS  PubMed  Google Scholar 

  20. Scoles PV, Quinn TP (1982) Intervertebral discitis in children and adolescents. Clin Orthop Relat Res 162:31–36

    PubMed  Google Scholar 

  21. Crawford AH, Kucharzyk DW, Ruda R, Smitherman HC Jr (1991) Diskitis in children. Clin Orthop Relat Res 266:70–79

    PubMed  Google Scholar 

  22. Jansen BR, Hart W, Schreuder O (1993) Discitis in childhood. 12-35-year follow-up of 35 patients. Acta Orthop Scand 64:33–36

    Article  CAS  PubMed  Google Scholar 

  23. Ryoppy S, Jaaskelainen J, Rapola J, Alberty A (1993) Nonspecific diskitis in children. A nonmicrobial disease? Clin Orthop Relat Res 297:95–99

    PubMed  Google Scholar 

  24. Ring D, Johnston CE 2nd, Wenger DR (1995) Pyogenic infectious spondylitis in children: the convergence of discitis and vertebral osteomyelitis. J Pediatr Orthop 15:652–660

    Article  CAS  PubMed  Google Scholar 

  25. Ventura N, Gonzalez E, Terricabras L, Salvador A, Cabrera M (1996) Intervertebral discitis in children: a review of 12 cases. Int Orthop 20:32–34

    Article  CAS  PubMed  Google Scholar 

  26. Ceroni D, Cherkaoui A, Kaelin A, Schrenzel J (2010) Kingella kingae spondylodiscitis in young children: toward a new approach for bacteriological investigations? A preliminary report. J Child Orthop 4:173–175

    Article  PubMed Central  PubMed  Google Scholar 

  27. Lew DP, Waldvogel FA (1997) Osteomyelitis. N Engl J Med 336:999–1007

    Article  CAS  PubMed  Google Scholar 

  28. Gutierrez K (2005) Bone and joint infections in children. Pediatr Clin North Am 52(779–794):vi

    Google Scholar 

  29. Fucs PM, Meves R, Yamada HH (2012) Spinal infections in children: a review. Int Orthop 36:387–395

    Article  PubMed  Google Scholar 

  30. Galil A, Gorodischer R, Bar-Ziv J, Hallel T, Malkin C, Garty R (1982) Intervertebral disc infection (discitis) in childhood. Eur J Pediatr 139:66–70

    Article  CAS  PubMed  Google Scholar 

  31. Wiley AM, Trueta J (1959) The vascular anatomy of the spine and its relationship to pyogenic vertebral osteomyelitis. J Bone Joint Surg 41-B:796–809

    CAS  Google Scholar 

  32. Whalen JL, Parke WW, Mazur JM, Stauffer ES (1985) The intrinsic vasculature of developing vertebral end plates and its nutritive significance to the intervertebral discs. J Pediatr Orthop 5:403–410

    Article  CAS  PubMed  Google Scholar 

  33. Song KS, Ogden JA, Ganey T, Guidera KJ (1997) Contiguous discitis and osteomyelitis in children. J Pediatr Orthop 17:470–477

    CAS  PubMed  Google Scholar 

  34. Glazer PA, Hu SS (1996) Pediatric spinal infections. Orthop Clin North Am 27:111–123

    CAS  PubMed  Google Scholar 

  35. Ratcliffe JF (1985) Anatomic basis for the pathogenesis and radiologic features of vertebral osteomyelitis and its differentiation from childhood discitis. A microarteriographic investigation. Acta Radiol Diagn (Stockh) 26:137–143

    CAS  Google Scholar 

  36. Garron E, Viehweger E, Launay F, Guillaume JM, Jouve JL, Bollini G (2002) Nontuberculous spondylodiscitis in children. J Pediatr Orthop 22:321–328

    PubMed  Google Scholar 

  37. King HA (1999) Back pain in children. Orthop Clin North Am 30(467–474):ix

    Google Scholar 

  38. Dormans JP, Moroz L (2007) Infection and tumors of the spine in children. J Bone Joint Surg Am 89(Suppl 1):79–97

    Article  PubMed  Google Scholar 

  39. du Lac P, Panuel M, Devred P, Bollini G, Padovani J (1990) MRI of disc space infection in infants and children. Report of 12 cases. Pediatr Radiol 20:175–178

    Article  PubMed  Google Scholar 

  40. Maliner LI, Johnson DL (1997) Intervertebral disc space inflammation in children. Childs Nerv Syst 13:101–103; discussion 104

    Article  CAS  PubMed  Google Scholar 

  41. Sobottke R, Seifert H, Fatkenheuer G, Schmidt M, Gossmann A, Eysel P (2008) Current diagnosis and treatment of spondylodiscitis. Dtsch Arztebl Int 105:181–187

    PubMed Central  PubMed  Google Scholar 

  42. Rothman SL (1996) The diagnosis of infections of the spine by modern imaging techniques. Orthop Clin North Am 27:15–31

    CAS  PubMed  Google Scholar 

  43. Chandrasenan J, Klezl Z, Bommireddy R, Calthorpe D (2011) Spondylodiscitis in children: a retrospective series. J Bone Joint Surg 93:1122–1125

    Article  CAS  Google Scholar 

  44. Paushter DM, Modic MT, Masaryk TJ (1985) Magnetic resonance imaging of the spine: applications and limitations. Radiol Clin North Am 23:551–562

    CAS  PubMed  Google Scholar 

  45. Digby JM, Kersley JB (1979) Pyogenic non-tuberculous spinal infection: an analysis of thirty cases. J Bone Joint Surg 61:47–55

    CAS  Google Scholar 

  46. Govender S (2005) Spinal infections. J Bone Joint Surg 87:1454–1458

    Article  CAS  Google Scholar 

  47. Eismont FJ, Bohlman HH, Soni PL, Goldberg VM, Freehafer AA (1982) Vertebral osteomyelitis in infants. J Bone Joint Surg 64:32–35

    CAS  Google Scholar 

  48. Tsirikos AI, Tome-Bermejo F (2012) Spondylodiscitis in infancy: a potentially fatal condition that can lead to major spinal complications. J Bone Joint Surg 94:1399–1402

    Article  CAS  Google Scholar 

  49. Reiss-Zimmermann M, Hirsch W, Schuster V, Wojan M, Sorge I (2010) Pyogenic osteomyelitis of the vertebral arch in children. J Pediatr Surg 45:1737–1740. doi:10.1016/j.jpedsurg.2010.04.010

    Article  PubMed  Google Scholar 

  50. Correa AG, Edwards MS, Baker CJ (1993) Vertebral osteomyelitis in children. Pediatr Infect Dis J 12:228–233

    Article  CAS  PubMed  Google Scholar 

  51. Buoncristiani AM, McCullen G, Shin AY, Bathgate B, Akbarnia BA (1998) An unusual cause of low back pain. Osteomyelitis of the spinous process. Spine 23:839–841

    Article  CAS  PubMed  Google Scholar 

  52. Skaf GS, Domloj NT, Fehlings MG, Bouclaous CH, Sabbagh AS, Kanafani ZA, Kanj SS (2010) Pyogenic spondylodiscitis: an overview. J Infect Public Health 3:5–16

    Article  CAS  PubMed  Google Scholar 

  53. Ananthakrishnan G, Wilkinson AG, McGurk SF, Marshall T (2009) Infantile chylothorax associated with staphylococcal paravertebral discitis. Pediatr Radiol 39:1354–1356

    Article  PubMed  Google Scholar 

  54. Robson JM, Harte GJ, Osborne DR, McCormack JG (1999) Cat-scratch disease with paravertebral mass and osteomyelitis. Clin Infect Dis 28:274–278

    Article  CAS  PubMed  Google Scholar 

  55. Abdel-Haq N, Abuhammour W, Al-Tatari H, Asmar B (2005) Disseminated cat scratch disease with vertebral osteomyelitis and epidural abscess. South Med J 98:1142–1145

    Article  PubMed  Google Scholar 

  56. Tasher D, Armarnik E, Mizrahi A, Liat BS, Constantini S, Grisaru-Soen G (2009) Cat scratch disease with cervical vertebral osteomyelitis and spinal epidural abscess. Pediatr Infect Dis J 28:848–850

    Article  PubMed  Google Scholar 

  57. Modic MT, Pavlicek W, Weinstein MA, Boumphrey F, Ngo F, Hardy R, Duchesneau PM (1984) Magnetic resonance imaging of intervertebral disk disease. Clinical and pulse sequence considerations. Radiology 152:103–111

    Article  CAS  PubMed  Google Scholar 

  58. Dagirmanjian A, Schils J, McHenry M, Modic MT (1996) MR imaging of vertebral osteomyelitis revisited. AJR Am J Roentgenol 167:1539–1543

    Article  CAS  PubMed  Google Scholar 

  59. Pui MH, Mitha A, Rae WI, Corr P (2005) Diffusion-weighted magnetic resonance imaging of spinal infection and malignancy. J Neuroimaging 15:164–170

    Article  PubMed  Google Scholar 

  60. Post MJ, Bowen BC, Sze G (1991) Magnetic resonance imaging of spinal infection. Rheum Dis Clin North Am 17:773–794

    CAS  PubMed  Google Scholar 

  61. Akhaddar A, Gourinda H, el Alami Z, el Madhi T, Miri A (1999) Hydatid cyst of the sacrum. Report of a case. Rev Rhum 66:289–291

    CAS  Google Scholar 

  62. Brook I (2001) Two cases of diskitis attributable to anaerobic bacteria in children. Pediatrics 107, E26

    Article  CAS  PubMed  Google Scholar 

  63. Trobs RB, Handrick W, Lotz I, Bankwitz C, Tannapfel A (2005) Vertebral osteomyelitis in an infant presenting with pseudotumor and narrowing of the spinal canal. Pediatr Surg Int 21:316–319

    Article  PubMed  Google Scholar 

  64. Rumana M, Mahadevan A, Nayil Khurshid M, Kovoor JM, Yasha TC, Santosh V, Indira B, Shankar SK (2006) Cestode parasitic infestation: intracranial and spinal hydatid disease–a clinicopathological study of 29 cases from South India. Clin Neuropathol 25:98–104

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ahmet Alanay MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Alanay, A., Yilgor, C. (2016). Acute Pediatric Spinal Infections. In: Akbarnia, B., Yazici, M., Thompson, G. (eds) The Growing Spine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48284-1_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-48284-1_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-48283-4

  • Online ISBN: 978-3-662-48284-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics