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Molekulare Mechanismen der Zellalterung und ihre Bedeutung für Alterserkrankungen des Menschen pp 109–121Cite as

Ausgewählte altersbedingte Erkrankungen

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Zusammenfassung

Alte Menschen sind häufig von mehreren altersbedingten Beeinträchtigungen und Erkrankungen gleichzeitig betroffen (Multimorbidität), was die Untersuchung und das Verständnis der Verknüpfung zwischen der Alterung als dem entscheidenden Risikofaktor und einzelnen Syndromen schwierig macht. In einigen Kapiteln dieses Buchs wurden schon Verbindungen zwischen den molekularen Mechanismen der Alterung und der Pathogenese altersassoziierter Krankheiten aufgezeigt. Hier nun liegt der Fokus auf der Alzheimer‐Krankheit (AD, Alzheimer’s disease) und Krebs. Während Krebs mittlerweile in vielen Fällen pharmakologisch und/oder chirurgisch erfolgreich behandelt und manchmal sogar geheilt werden kann, ist AD noch immer eine unheilbare, tödlich verlaufende Erkrankung. Wie bei fast keiner anderen Krankheit ist das Auftreten von AD strikt mit dem Alter verknüpft und lässt einen starken Anstieg der Zahl der Krankheitsfälle für unsere alternde Gesellschaft erwarten. Die Autoren sind der Überzeugung, dass die eigentlichen Ursachen der Alzheimer‐Krankheit nur identifiziert werden können, wenn die Biochemie alternder Neuronen verstanden wird, speziell im Kontext bekannter Risikofaktoren.

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Authors and Affiliations

  1. Institut für Pathobiochemie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland

    Christian Behl & Christine Ziegler

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  1. Christian Behl
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  2. Christine Ziegler
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Correspondence to Christian Behl or Christine Ziegler .

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Behl, C., Ziegler, C. (2016). Ausgewählte altersbedingte Erkrankungen. In: Molekulare Mechanismen der Zellalterung und ihre Bedeutung für Alterserkrankungen des Menschen. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48250-6_4

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