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Skelettveränderungen bei Erkrankungen des retikulohistiozytären Systems

  • J. Freyschmidt

Zusammenfassung

Erkrankungen des retikulohistiozytären Systems können – seinen verschiedenartigen Aufgaben und zellulären Zusammensetzung entsprechend – ein breites Spektrum von Krankheiten im muskuloskelettalen Apparat auslösen, zu denen so seltene erbliche Krankheitsbilder wie Lipid- und Glykogenspeicherkrankheiten, aber auch geläufige Erkrankungen wie die Langerhans-Zell-Histiozytose und die Mastozytose zählen. Die seltene Lipoidgranulomatose zählt man heute zu den Non-Langerhans-Zell-Histiozytosen. Die radiologischen Veränderungen am Knochen sind vielschichtig und in den meisten Fällen sehr spezifisch.

Literatur

  1. Adam C, Hélie O, Lévêque CR (2005) Case 78: Erdheim-Chester disease with central nervous system involvement. Radiology 234:11–1CrossRefGoogle Scholar
  2. Amini B, Kumar R, Wang WL (2013) Soft tissue Langerhanscell histiocytosis with secondary bone involvement in extremities: evolution in two cases. Skeletal Radiol 42:130–1CrossRefGoogle Scholar
  3. Avila NA, Ling A, Metcalfe DD et al (1998) Mastocytosis: magnetic resonance imaging patterns of marrow disease. Skeletal Radiol 27:11–9CrossRefGoogle Scholar
  4. Bancroft LW, Berquist TH (1998) Erdheim-Chester disease: radiografic findings in five patients. Skeletal Radiol 27:12–7Google Scholar
  5. Bartholdy N, Thommesen P (1983) Histiocytosis X. VII. Prognostic significance of skull lesions. Acta Radiol Oncol 22:12–5Google Scholar
  6. Benz-Bohm, G, Georgi P (1981) Szintigrafische und radiologische Befunde beim eosinophilen Granulom. Radiologe 21:19–5Google Scholar
  7. Bergholz M, Schauer A, Poppe H (1979) Diagnostic and differential diagnostic aspects in Histiocytosis X disease. Pathol Res Pract 166:5–9CrossRefGoogle Scholar
  8. Berning W, Freyschmidt J (1985) Zur Klinik und Radiologie der Histozytose X am Skelett - eine retrospektive Studie an 18 Patienten. Röntgenblätter 38:40–0Google Scholar
  9. Biehler EU, Wohlenberg H, Utech CH (1985) Die ossären Manifestationen bei der generalisierten Mastozytose im Skelettszintigramm im Vergleich zum Röntgenbefund. RÖFO 142:52–2Google Scholar
  10. Bonakdarpur A, Mayer DP, Clanay M et al (1982) Case report 208. Diagnosis: Eosinophilic granuloma of the right pedicle, and posterior elements of Thai. Skeletal Radiol 8:31–9Google Scholar
  11. Brecht G, Kanzow G (1983) Klinisch stumme Mastozytose - Haut und isolierter Rippenbefall. RÖFO 139: 9–9Google Scholar
  12. Brinkley AB, O’Brian MW (1985) Localized eosinophilic fibrohistiocystic lesions of bone (tibia) - a localized form of mastocytosis. Skeletal Radiol 14:6–8CrossRefGoogle Scholar
  13. Brower AC, Worsham GF, Dudley AH (1984) ErdheimChester disease: a distinct lipiodosis or part of the spectrum of histiocytosis? Radiology 151:3–5CrossRefGoogle Scholar
  14. Burgener FA (1977) Die Röntgenmanifestation der disseminierten Histiozytosis X beim Erwachsenen. RÖFO 126:46–6Google Scholar
  15. Chester W (1930) Über Lipoidgranulomatose. Virchows Arch Pathol Anat 279:56–1Google Scholar
  16. Chevrant-Breton J, Laudren A, Mazdas D et al (1981) Maladie de Fabry. Lymphoedhle et acropathie ulcro-mutilante - un cas. Ann Derm Venereol (Paris) 108:89–9Google Scholar
  17. Cheyne C (1971) Histiocytosis X. J Bone Joint Surg [Br] 53:36–6Google Scholar
  18. Cohen M, Zornoza J, Cangir A et al (1980) Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone. Radiology 136:28–9CrossRefGoogle Scholar
  19. Colombi A., Kostyal A, Bracher R et al (1967) Angioceratoma corporis diffusum - Fabry's disease. Helv Med Acta 34:6–7Google Scholar
  20. Cyndy T, Beneton MNC, Darby AJ et al (1987) Osteopenia in systemic mastocytosis: natural history and responses to inhibitors of bone resorption. Bone 8:14–9Google Scholar
  21. Dalinka MK, Turner ML, Thomson JJ et al (1982) Lipid granulomatosis of the ribs. Radiology 142:29–7CrossRefGoogle Scholar
  22. Dion E, Graef C, Miguel A et al (2006) Bone involvement in Erdheim-Chester disease: Imaging finding including periostitis and partial epiphyseal involvement. Radiology 238:63–2CrossRefGoogle Scholar
  23. Dempsey H, Hartley MW, Carroll J et al (1965) Fabry's disease (angioceratoma corporis diffusum). Case report on a rare disease. Ann Intern Med 63:105–9CrossRefGoogle Scholar
  24. Enriquez P, Dahlin DC, Hayles AG, Henderson ED (1967) Histiocytosis X: a clinical study. Mayo Clin Proc 42:8–8Google Scholar
  25. Fallon MD, Whyte MP, Craig B et al (1983) Mast cell proliferation in post-menopausal osteoporosis. Calcif Tissue Int 33:2–9Google Scholar
  26. Fischer E (1986) Morbus Fabry, eine Erkrankung mit Rheumaaspekten: Radiologie der Weichteil- und Knochenveränderungen an der Hand. Z Rheumatol 45:3–6Google Scholar
  27. Fone DJ, King WE (1964) Angioceratoma corporis diffusum (Fabry's syndrome). Aust Ann Med 13:33–9Google Scholar
  28. Frame B, Nixon RK (1968) Bone-marrow mast cells in osteoporosis of aging. N Eng J Med 279: 62–6CrossRefGoogle Scholar
  29. Freyschmidt J, Ostertag H, Lang W (1986) Erdheim-Chester disease (case report 365) Skeletal Radiol 15:31–6Google Scholar
  30. Gandolfi A (1983) Vertebral histiocytosis-X causing spinal cord compression. Surg Neurol 19:36–9Google Scholar
  31. Goldblatt J, Sacks S, Beighton P (1978) The orthopedic aspects of Gaucher's disease. Clin Orthp 137:20–8Google Scholar
  32. Golduran AB, Jacobs B (1984) Femoral neck fractures complicating Gaucher disease in children. Skeletal Radiol 12:16–2Google Scholar
  33. Greenfield GB (1970) Bone changes in chronic adult Gaucher's disease. AJR 110: 80–0CrossRefGoogle Scholar
  34. Greinacher I, Gutjahr P (1978) Histiocytosis X. Röntgenbefunde an der Wirbelsäule des Kindes. Radiologe 18:22–8Google Scholar
  35. Griffith GC, Nichols G, Asher JD et al (1965) Heparin osteoporosis. JAMA 193:9–1CrossRefGoogle Scholar
  36. Groen J (1964) Gaucher's disease: hereditary transmission and racial distribution. Arch Intern Med 113: 54–3CrossRefGoogle Scholar
  37. Herman G, Shapiro R, Abdelwahab IF et al (1994) Extraosseous extension of Gaucher cell deposits mimicking malignancy. Skeletal Radiol 23:25–3Google Scholar
  38. Hindman BW, THomas RD, Young LW et al (1998) Langerhans cell histiocytosis: unusual skeletal manifestations observed in thirty-four cases. Skeletal Radiol 27:17–7CrossRefGoogle Scholar
  39. Hoffmann B, Mayatepek E (2009) Morbus Fabry-oft gesehen, selten erkannt. Deutsches Ärzteblatt 106:44–0Google Scholar
  40. Horev G, Kornreich L, Hadar H (1991) Hemorrhage associated with »bone crisis« in Gaucher's disease identified by magnetic resonance imaging. Skeletal Radiol 20:47–9CrossRefGoogle Scholar
  41. Horny HP, Parwaresch MR, Lennert K (1983) Klinisches Bild und Prognose generalisierter Mastozytosen. Klin Wschr 61:78–5CrossRefGoogle Scholar
  42. Ivan D, Neto A, Lemos L et al (2003) Erdheim-Chester disease: a unique presentation with liver involvement and vertebral osteolytic lesions. Arch Pathol Lab Med 127:33–7Google Scholar
  43. Jaffe HL (1972) Metabolic, degenerative and inflammatory diseases of bones and joints. Lea & Febiger, Philadelphia, pp 535–541Google Scholar
  44. Jaspers C, Bauer R, König E et al (1994) Ungewöhnlicher Verlauf einer schweren Osteoporose. Internist 35:93–4Google Scholar
  45. Jennings CD, Stelling CB, Powell DE (1982) Case report 199. Diagnosis: Eosinophilic granuloma of the right third metacarpal. Skeletal Radiol 8:22–9CrossRefGoogle Scholar
  46. Joo CU, Go YS, Kim JH et al (2005) Erdheim-Chester disease in a child with MR imaging showing regression of marrow changes. Skeletal Radiol 34:29–9CrossRefGoogle Scholar
  47. Kellinghaus H, Raidt H, Steinmeier R et al (1982) Histiocytosis X bei Erwachsenen. Med Welt 33: 184–0Google Scholar
  48. Kenn W, Stäbler A, Zachoval R et al (1999) Erdheim-Chester disease: a case report and literature overview. Eur Radiol 9:15–3CrossRefGoogle Scholar
  49. Kilborn TN, Teh J, Goodman TR (2003) Pediatric manifestations of Langerhans cell histiocytosis: a review of the clinical and radiological findings. Clinical Radiol 58:26–9CrossRefGoogle Scholar
  50. Kluin-Nelemans HC, Jansen JP, Breukelman H et al (1992) Response to interferon alfa-2b in a patient with systemic mastocytosis. N Engl J Med 362:61–9Google Scholar
  51. Lachmann R, Crocker A, Schulman J et al (1973) Radiological findings in Niemann-Pick disease. Radiology 108:65–9Google Scholar
  52. Lacroux R (1960) Angiokératome diffus (angiokeratoma corporis diffusum) de Fabry. Bull Soc Franc Derm Syph 67:47–4Google Scholar
  53. Lanir A, Hadar H, Cohen I et al (1986) Gaucher disease: assessment with MR imaging. Radiology 161:23–9CrossRefGoogle Scholar
  54. Lichtenstein L (1953) Histiocytosis X. Integration of eosinophilic granuloma of bone, »Letterer-Siwe disease«, and »Schuller-Christian disease« as related manifestations of a single nosologic entity. Arch Pathol Lab Med 56:5–6Google Scholar
  55. Lidor C, Frisch B, Gazit D et al (1990) Osteoporosis as the sole presentation of bone marrow mastocytosis. J Bone Min Res 5:87–1Google Scholar
  56. Lyders EM, Kauslik S, Perez-Berenguer J et al (2003) Aggressive and atypical manifestations of Erdheim-Chester disease. Clin Rheumatol 22:46–4CrossRefGoogle Scholar
  57. Madewell JE, Ragsdale BD, Sweet DE (1981) Radiologic and pathologic analysis of solitary bone lesions. Radiol Clin NA 19:71–5Google Scholar
  58. Manger B, Mengel E, Schaefer R et al (2006) M. Gaucher, M. Fabry und Mukopolysaccharidose Typ I. Z Rheumatol 65:3–2CrossRefGoogle Scholar
  59. McCullough CJ (1980) Eosinophilic granuloma of bone. Acta orthop stand 51:38–9Google Scholar
  60. Miller JH, Stanley P, Gates GF (1979) Radiografy of glycogen storage diseases. AJR 132:37–9CrossRefGoogle Scholar
  61. Nauert C, Zornoza J, Ayala A, Harle TS (1983) Eosinophilic granuloma of bone: diagnosis and management. Skeletal Radiol 10:22–7CrossRefGoogle Scholar
  62. Netzelof C, Basset F, Rousseau MF (1973) Histiocytosis X: Histogenetic arguments for a Langerhans cell origin. Biomedicine 18:36–5Google Scholar
  63. Pankow W, Ehlenz K, Buhr T et al (1992) Osteoporotische Wirbelkörperfrakturen bei systemischer Mastozytose ohne Hautbeteiligung. Dtsch Med Wochenschr 117:171–7CrossRefGoogle Scholar
  64. Poll LW, Koch J-A, Dahl S von et al (2000) Type I Gaucher disease: extraosseous extension of skeletal disease. Skeletal Radiol 29:1–5CrossRefGoogle Scholar
  65. Poll LW, Maas M, Terk MR et al (2002) Response of Gaucher bone disease to enzyme replacement therapy. Br J Radiol 75 (Suppl 1):A25–36PubMedGoogle Scholar
  66. Poll LW, Dahl S von, Koch J-A et al (2001) Morbus Gaucher: Analyse der Knochenmarkveränderungen in der MRT während Enzymersatztherapie. Fortschr Röntgenstr 173:93–1CrossRefGoogle Scholar
  67. Poll LW, Willers R, Häussinger D et al (2010) MRI bone marrow findings in 63 patients with Type I Gaucher disease. Fortschr Röntgenstr 182:97–9CrossRefGoogle Scholar
  68. Prager PJ, Menges V, Di Base M, Wurster KH, Krastel A, Assmus H (1976) Das eosinophile Knochengranulom bei Erwachsenen. Radiologe 16:2–1Google Scholar
  69. Preger L (1969) Roentgenografic skeletal changes in the glycogen storage diseases. AJR 107:84–0Google Scholar
  70. Remy R, Göbel U, Goerz G, Müntefering H (1979) Spontanremission einer konnatalen Histiozytose X. Klin Pädiatr 191:22–5Google Scholar
  71. Resnick D (1981) Lipidosis histiocytosis and hyperlipoproteinemias. In: Resnick D, Niwayama G Diagnosis of bone and joint disorders. Saunders, Philadelphia, pp 1948–1991Google Scholar
  72. Resnick D, Greenway G, Genant H et al (1982) Erdheim-Chester disease. Radiology 142:28–9CrossRefGoogle Scholar
  73. Roberts II. LJ, Sweetman BJ, Lewis RA et al (1980) Increased production of prostaglandin D2 in patients with systemic mastocytosis. N Engl J Med 303:140–0Google Scholar
  74. Rodenberg JC, Maegaard KK, Svanholm H (1986) Systemic mastocytosis (case report 369). Skeletal Radiol 15:33–4CrossRefGoogle Scholar
  75. Rohner HG, Bartl R, Klingmüller G et al (1980) Die Mastozytose - eine Krankheit mit häufiger Systemisierung. Therapiewoche 30:677–3Google Scholar
  76. Rosenbaum RC, Frieri M, Metcalfe DD (1984) Patterns of skeletal scintigrafy and their relationship to plasma and urinary histamine levels in systemic mastocytosis. J Nucl Med 25:85–9Google Scholar
  77. Ruff St, Chapman GK, Taylor TKF, Ryan MD (1983) The evolution of eosinophilic granuloma of bone: a case report. Skeletal Radiol 10:3–7CrossRefGoogle Scholar
  78. Sartoris DJ, Parker BR (1984) Histiocytosis X; rate and pattern of resolution of osseous lesions. Radiology 152:67–9Google Scholar
  79. Schajowicz F, Slullitel J (1973) Eosinophilic granuloma of bone and its relationship to Hand-Schüller-Christian and Letterer-Siwe syndromes. J Bone Joint Surg [Br] 55:54–5Google Scholar
  80. Schweitzer ME, Irwin GAL (1989) Systemic mastocytosis. Skeletal Radiol 18:41–1Google Scholar
  81. Semerak M (1980) Urticaria pigmentosa mit Skelettbeteiligung - Masto zytosesyndrom. RÖFO 133: 67–3Google Scholar
  82. Siegelman SS (1997) Taking the X out of histiocytosis X. Radiology 204: 32–2CrossRefGoogle Scholar
  83. Simpson FG, Robinson PJ, Hardy GJ et al (1979) Erdheim-Chester disease associated with retroperitoneal xanthogranuloma. Br J Radiol 52:23–2CrossRefGoogle Scholar
  84. Strouse PJ, Ellis BJ, Shifrin LZ et al (1992) Case report 710. Skeletal Radiol 21:6–4CrossRefGoogle Scholar
  85. Takahashi M, Martel W, Oberman HA (1966) The variable roentgenografic appearance of idiopathic histiocytosis. Clin Radiol 17:4–8CrossRefGoogle Scholar
  86. Terk MR, Dardashi S, Liebman HA (2000) Bone marrow response in treated patients with Gaucher disease: evaluation by T1-weighted magnetic resonance imaging and correlation with reduction in liver and spleen volume. Skeletal Radiol 29:56–3CrossRefGoogle Scholar
  87. Travis WD, Li CY, Bergstralh EJ et al (1988) Systemic mast cell disease: analysis of 58 cases and literature review. Medicine 67:34–5CrossRefGoogle Scholar
  88. Vassallo R, Ryu JH, Colby TV (2000) Pulmonary Langerhans' cell histiocytosis. N Engl J Med 342:196–9CrossRefGoogle Scholar
  89. Vassallo R, Ryu JH, Schroeder DR et al (2002) Clinical outcome of pulmonary Langerhans' cell histiocytosis in adults. N Engl J Med 346:48–4CrossRefGoogle Scholar
  90. Veyssier-Belot C, Cacoub T, Caparros-Lefebore et al (1996) Erdheim-Chester disease: clinical and radiologic characteristics of 59 cases. Medicine 75:15–7Google Scholar
  91. Weisstein JS, Steinbach LS, Diamond CA (2001) Pseudo-osteomyelitic crisis upon presentation of Gaucher disease. Skeletal Radiol 30:40–7CrossRefGoogle Scholar
  92. Wittenberg KN, Swensen SJ, Myers JL (2000) Pulmonary involvement with Erdheim-Chester disease: radiografic and CT findings. AJR 174:132–7CrossRefGoogle Scholar
  93. Wright RA, Hermann RC, Parisi JE (1999) Neurological manifestations of Erdheim-Chester disease. J Neurol Neurosurg Psychiatry 66:7–2CrossRefGoogle Scholar
  94. Zimran A, Gelbart T, Westwood B et al (1991) High frequency of the Gaucher disease mutation at nucleotide 1226 among Ashkenazi Jews. Am J Hum Genet 49:8Google Scholar

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© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • J. Freyschmidt
    • 1
  1. 1.Klinikum Bremen-Mitte Beratungsstelle und ReferenzzentrumBremen

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