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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement pp 121–136Cite as

Surface-Charged Vesicles for Penetration Enhancement

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Abstract

This chapter aims to summarize the current approaches employed in delivering drugs through the skin, focusing in vesicle systems. In recent years, several vesicles have been developed to improve the permeation of drugs through the skin. Different types of lipid vesicles are formulated depending on the additives used for preparation: Transfersome™, flexosomes, ethosomes, niosomes, vesosomes, invasomes, and polymerosomes. In addition, an exhaustive revision about different strategies to provide positive or negative charge to the liposomes has been reported. Also, the influence of physicochemical properties of drug on the permeation behavior from these vesicles has been analyzed. Finally, new strategies and advances in the use of charged liposomes have also included.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, C/ Prof. García González, 2, Seville, 41012, Spain

    María Luisa González-Rodríguez, María José Cózar-Bernal & Antonio María Rabasco

  2. Department of Metals Science, Electrochemistry and Chemical Technique, University of Bologna, Via San Donato 15, Bologna, 40127, Italy

    Adamo Fini

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  1. María Luisa González-Rodríguez
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  2. María José Cózar-Bernal
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  3. Adamo Fini
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  4. Antonio María Rabasco
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Correspondence to María Luisa González-Rodríguez .

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  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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González-Rodríguez, M.L., Cózar-Bernal, M.J., Fini, A., Rabasco, A.M. (2016). Surface-Charged Vesicles for Penetration Enhancement. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47862-2_8

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