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Vesicular Carriers for Transcutaneous Immunization

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Book cover Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

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Abstract

Transcutaneous immunization (TCI) is a novel strategy of vaccine delivery that utilizes a topical application of an adjuvant and vaccine antigen to intact skin to induce an immune response. It has received wide interest due to its easy-to-use, needle-free, and noninvasive delivery. To overcome the limitations involved with vaccine delivery, novel drug delivery systems are being investigated which successfully overcome the problems regarding the patient compliance, safety, and opened up both opportunities/options for alternative therapeutic strategies to evoke immunological responses without breaching the skin barrier. Topical immunization through the vesicular approach is gaining a worldwide recognition nowadays. It includes the utilization of carriers like liposomes, niosomes, ethosomes, and transferosomes, since they are proficient in transferring immunogens as deoxyribonucleic acid (DNA) and antigens across the intact skin by enhancing skin permeability. These vesicular carriers utilize different pathways in the skin, i.e., either through keratinocytes intercellularly or through follicles, to cross the barrier and reach the desired cells.

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Authors and Affiliations

  1. Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Vishwavidyalaya, Sagar, MP, 470003, India

    Udita Agrawal, Madhu Gupta & Suresh P. Vyas

Authors
  1. Udita Agrawal
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  2. Madhu Gupta
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  3. Suresh P. Vyas
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Corresponding author

Correspondence to Suresh P. Vyas .

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Editors and Affiliations

  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Agrawal, U., Gupta, M., Vyas, S.P. (2016). Vesicular Carriers for Transcutaneous Immunization. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47862-2_21

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  • DOI: https://doi.org/10.1007/978-3-662-47862-2_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47861-5

  • Online ISBN: 978-3-662-47862-2

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