Abstract
The two major obstacles to noninvasive administration of biologicals in dermatology are that delivery of proteins across the skin is highly limited and traditional permeation enhancers are ineffective for large compounds. Biphasic vesicles are a novel-type formulation in which permeation-enhancing components are structurally organized as a complex lipid vesicle. Biphasic vesicles can encapsulate macromolecules; using interferon alpha as a model protein, cutaneous delivery and a novel nanopathway, characterized by lamellar-to-cubic polymorphic-phase change in the stratum corneum lipid channels, were demonstrated. This opens up possibilities to design delivery systems capable of structural reorganization of lamellar membranes resulting in enhanced permeability.
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The authors thank Marina Ivanova for editing the manuscript.
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Foldvari, M., Kumar, P. (2016). Permeation Enhancement by Molecular Organization Switching (MOS): Biphasic Vesicles for the Cutaneous Delivery of Proteins. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47862-2_20
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DOI: https://doi.org/10.1007/978-3-662-47862-2_20
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