Protein Contact Dermatitis and Testing

  • Ana Gimenez-ArnauEmail author


Protein contact dermatitis (PCD) was defined in 1976 as an immediate eczema induced after contact with proteins. PCD and contact urticaria (CoU) are both induced by environmental triggers and belong to a more general syndrome, the contact urticaria syndrome (CUS). The global incidence and occupational relevance of PCD is not known, but immediate contact reactions are common in dermatological practice. A combination of type I and type IV allergic skin reactions has been suggested as PCD pathogenesis. Diagnosis of PCD as of any of the diseases included in the CUS is based on full medical history and skin testing with suspected substances. The best way to treat PCD is based in a correct etiological diagnosis. The knowledge of PCD shows some challenges that still need further research.


Contact urticaria Dermatitis Eczema Immediate contact reaction Immunology Protein contact dermatitis Syndrome Urticaria 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of DermatologyHospital del Mar, Universitat Autònoma de BarcelonaBarcelonaSpain

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