Abstract
Several thousands of synthetic or natural (mixtures of) fragrances are used mainly for perfuming cosmetic products, but partly also in household or technical products, topical medicines or toys. Routine patch testing uses fragrance mix I (seven synthetics and one natural extract), II (five synthetics – one, hydroxyisohexyl 3-cyclohexene carboxaldehyde, presently also tested as single allergen at 5 % in petrolatum) and Myroxylon pereirae resin (Balsam of Peru). Around 16 % of consecutively patch-tested patients are positive to these markers. The patient’s history as well as clinical presentation may either be suggestive of fragrances as cause of contact dermatitis (e.g. fine fragrances, after shaves, deodorants) or less suggestive if, e.g. fragranced body lotions, hand creams, etc. have caused dermatitis. Patch testing of own products and, in case of diagnostic doubt, repeated open application testing are valuable tools to better diagnose or verify contact sensitisation to a fragrance compound. Secondary prevention relies on ingredient information (not only, but foremost, in cosmetics) as (1) basis for adequate patch testing and (2) later allergen avoidance.
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References
Api AM, Basketter DA, et al. Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Regul Toxicol Pharmacol. 2008;52(1):3–23.
Bonefeld CM, Nielsen MM, et al. Enhanced sensitization and elicitation responses caused by mixtures of common fragrance allergens. Contact Dermatitis. 2011;65(6):336–42.
Bruze M, Svedman C, et al. Patch test concentrations (doses in mg/cm2) for the 12 non-mix fragrance substances regulated by European legislation. Contact Dermatitis. 2012;66(3):131–6.
Buckley DA, Rycroft RJ, et al. The frequency of fragrance allergy in patch-tested patients increases with their age. Br J Dermatol. 2003;149(5):986–9.
Frosch PJ, Geier J, et al. Patch testing with the patient’s own products. In: Johansen JD, Frosch PJ, Lepoittevin JP, editors. Contact dermatitis. Heidelberg: Springer; 2011. p. 1107–19.
Johansen JD, Frosch PJ, et al. Allergic contact dermatitis in humans: experimental and quantitative aspects. In: Johansen JD, Frosch PJ, Lepoittevin JP, editors. Contact dermatitis. Heidelberg: Springer; 2011. p. 241–51.
Karlberg A-T, Börje A, et al. Activation of non-sensitizing or low-sensitizing fragrance substances into potent sensitizers - prehaptens and prohaptens. Contact Dermatitis. 2013;69(6):323–34.
Pfützner W, Thomas P, et al. Systemic contact dermatitis elicited by oral intake of Balsam of Peru. Acta Derm Venereol. 2003;83(4):294–5.
Salam TN, Fowler Jr JF. Balsam-related systemic contact dermatitis. J Am Acad Dermatol. 2001;45(3):377–81.
SCCS. SCCS (Scientific Committee on Consumer Safety), opinion on fragrance allergens in cosmetic products. Brussels: European Commission, DG SANCO; 2012.
Schnuch A, Oppel E, et al. Experimental inhalation of fragrance allergens in predisposed subjects: effects on skin and airways. Br J Dermatol. 2010;162(3):598–606.
Uter W, Geier J, et al. Risk factors associated with sensitization to hydroxyisohexyl 3-cyclohexene carboxaldehyde. Contact Dermatitis. 2013;69(2):72–7.
Uter W, Johansen JD, et al. Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure-activity relationships. Contact Dermatitis. 2013;69(4):196–230.
Uter W, Schnuch A, et al. Association between occupation and contact allergy to the fragrance mix: a multifactorial analysis of national surveillance data. Occup Environ Med. 2001;58(6):392–8.
Uter W, Yazar K, et al. Coupled exposure to ingredients of cosmetic products: I. fragrances. Contact Dermatitis. 2013;69:335–41.
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Uter, W. (2016). Fragrances. In: Johansen, J., Lepoittevin, JP., Thyssen, J. (eds) Quick Guide to Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47714-4_12
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DOI: https://doi.org/10.1007/978-3-662-47714-4_12
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