Abstract
Candida-associated denture stomatitis is a common fungal infection that affects removable denture wearers. Although Candida spp. are considered commensal fungal in the oral cavity, changes in local and/or systemic predisposing factors related to the host conditions may lead to pathogenic form and cause disease. The clinical manifestations are usually associated with the predisposing factors, changing from no symptoms to severe pain and difficulty swallowing. The therapeutic strategies commonly adopted in the clinical practice are the use of topical and/or systemic antifungal, in addition to removing mechanically the plaque from denture surfaces and from underlying mucosa and give instructions about the correct oral hygiene to the patient. In this context, considering the high prevalence of this disease in the clinical practice, a review about the etiology, risk factors, clinical manifestations, and therapy management of these patients is of utmost importance.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cueto A, Martínez R, Niklander S, Deichler J, Barraza A et al (2013) Prevalence of oral mucosal lesions in an elderly population in the city of Valparaiso, Chile. Gerodontology 30(3):201–206
Daniluk T, Tokajuk G, Stokowska W, Fiedoruk K, Sciepuk M et al (2006) Occurrence rate of oral Candida albicans in denture wearer patients. Adv Med Sci 51:77–80
Davis D (2003) Adaptation to environmental pH in Candida albicans and its relation to pathogenesis. Curr Genet 44(1):1–7
de Oliveira CE, Gasparoto TH, Dionísio TJ, Porto VC, Vieira NA et al (2010) Candida albicans and denture stomatitis: evaluation of its presence in the lesion, prosthesis, and blood. Int J Prosthodont 23(2):158–159
Dorocka-Bobkowska B, Konopka K (2007) Susceptibility of candida isolates from denture-related stomatitis to antifungal agents in vitro. Int J Prosthodont 20(5):504–506
Emami E, de Grandmont P, Rompré PH, Barbeau J, Pan S et al (2008) Favoring trauma as an etiological factor in denture stomatitis. J Dent Res 87(5):440–444
Emami E, Kabawat M, Rompre PH, Feine JS (2014) Linking evidence to treatment for denture stomatitis: a meta-analysis of randomized controlled trials. J Dent 42(2):99–106
Ene IV, Adya AK, Wehmeier S, Brand AC, MacCallum DM et al (2012) Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. Cell Microbiol 14(9):1319–1335
Girtan M, Zurac S, Stăniceanu F, Bastian A, Popp C et al (2009) Oral epithelial hyperplasia in diabetes mellitus. Rom J Intern Med 47(2):201–203
Harriott MM, Noverr MC (2011) Importance of Candida-bacterial polymicrobial biofilms in disease. Trends Microbiol 19(11):557–563
Jayatilake JA (2011) A review of the ultrastructural features of superficial candidiasis. Mycopathologia 171(4):235–250
Lalla RV, Patton LL, Dongari-Bagtzoglou A (2013) Oral candidiasis: pathogenesis, clinical presentation, diagnosis and treatment strategies. J Calif Dent Assoc 41(4):263–268
Lotfi-Kamran MH, Jafari AA, Falah-Tafti A, Tavakoli E, Falahzadeh MH (2009) Candida colonization on the denture of diabetic and non-diabetic patients. Dent Res J (Isfahan) 6(1):23–27
Montejo M (2011) Epidemiology of invasive fungal infection in solid organ transplant. Rev Iberoam Micol 28(3):120–123
Nett JE, Marchillo K, Spiegel CA, Andes DR (2010) Development and validation of an in vivo Candida albicans biofilm denture model. Infect Immun 78(9):3650–3659
Newton AV (1962) Denture sore mouth: a possible etiology. Br Dent J 1:357–360
Pereira CM, Pires FR, Corrêa ME, di Hipólito JO, Almeida OP (2004) Candida in saliva of Brazilian hemophilic patients. J Appl Oral Sci 12(4):301–306
Ramage G, VandeWalle K, Bachmann SP, Wickes BL, López-Ribot JL (2002) In vitro pharmacodynamic properties of three antifungal agents against preformed Candida albicans biofilms determined by time-kill studies. Antimicrob Agents Chemother 46(11):3634–3636
Salerno C, Pascale M, Contaldo M, Esposito V, Busciolano M et al (2011) Candida-associated denture stomatitis. Med Oral Patol Oral Cir Bucal 16(2):139–143
Sánchez-Vargas LO, Estrada-Barraza D, Pozos-Guillen AJ, Rivas-Caceres R (2013) Biofilm formation by oral clinical isolates of Candida species. Arch Oral Biol 58(10):1318–1326
Santana IL, Gonçalves LM, de Vasconcellos AA, da Silva WJ, Cury JA et al (2013) Dietary carbohydrates modulate Candida albicans biofilm development on the denture surface. PLoS One 8(5), e64645
Sardi JC, Scorzoni L, Bernardi T, Fusco-Almeida AM, Mendes Giannini MJ (2013) Candida species: current epidemiology, pathogenicity, biofilm formation, natural antifungal products and new therapeutic options. J Med Microbiol 62:10–24
Soysa NS, Ellepola AN (2005) The impact of cigarette/tobacco smoking on oral candidosis: an overview. Oral Dis 11(5):268–273
Spellberg BJ, Filler SG, Edwards JE Jr (2006) Current treatment strategies for disseminated candidiasis. Clin Infect Dis 42(2):244–251
Vallejo JA, Sánchez-Pérez A, Martínez JP, Villa TG (2013) Cell aggregations in yeasts and their applications. Appl Microbiol Biotechnol 97(6):2305–2318
Vasconcellos AA, Gonçalves LM, Del Bel Cury AA, da Silva WJ (2014) Environmental pH influences Candida albicans biofilms regarding its structure, virulence and susceptibility to fluconazole. Microb Pathog 69–70:39–44
Vazquez JA, Sobel DJ (2002) Mucosal candidiasis. Infect Dis Clin North Am 16(4):793–820
Webb BC, Thomas CJ, Willcox MD, Harty DW, Knox KW (1998a) Candida-associated denture stomatitis. Aetiology and management: a review. Part 2. Oral diseases caused by Candida species. Aust Dent J 43(3):160–166
Webb BC, Thomas CJ, Willcox MD, Harty DW, Knox KW (1998b) Candida-associated denture stomatitis. Aetiology and management: a review. Part 1. Factors influencing distribution of Candida species in the oral cavity. Aust Dent J 43(1):45–50
Wilberg P, Hjermstad MJ, Ottesen S, Herlofson BB (2014) Chemotherapy-associated oral sequelae in patients with cancers outside the head and neck region. J Pain Symptom Manage 48(6):1060–1069
Williams DW, Lewis MA (2000) Isolation and identification of Candida from the oral cavity. Oral Dis 6(1):3–11
Wilson J (1998) The aetiology, diagnosis and management of denture stomatitis. Br Dent J 185(8):380–384
Zissis A, Yannikakis S, Harrison A (2006) Comparison of denture stomatitis prevalence in 2 population groups. Int J Prosthodont 19(6):621–625
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
de Vasconcellos, A.A., Gonçalves, L.M., Del Bel Cury, A.A., da Silva, W.J. (2015). Candida-Associated Denture Stomatitis: Clinical Relevant Aspects. In: Ribeiro Rosa, E. (eds) Oral Candidosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47194-4_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-47194-4_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-47193-7
Online ISBN: 978-3-662-47194-4
eBook Packages: MedicineMedicine (R0)