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Antitussiva und Expektorantien

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Zusammenfassung

Seit 1995 sind die Verordnungen der Antitussiva und der Expektorantien stark zurückgegangen. Hauptgrund des rückläufigen Trends ist die zweifelhafte Wirksamkeit dieser Substanzen. Auch der Ausschluss rezeptfreier Arzneimittel aus der Erstattung hat die Abnahme des Verordnungsvolumens seit 2004 weiter beschleunigt. Im Jahre 2014 ist eine weitere Abnahme der Verordnungen zu verzeichnen.

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Literatur

  • AgenceNationaledeSecuriteduMedicamentetdesProduitsdeSante(Afssaps)(2010):Retraitdesspecialitemucolytiqueschezlenourrisson:derniereetapedel'operationderappel.MED10/A17/B09.29.4.2010

    Google Scholar 

  • American Academy of Pediatrics Committee on Drugs(1997):Useofcodeine-anddex-tromethorphan-containingcoughremediesinchildren.Pediatrics99:918–920

    Article  Google Scholar 

  • ArzneimittelkommissionderdeutschenÄrzteschaft(2009):Arzneiverordnungen,22.Auflage;

    Google Scholar 

  • Arzneimittelkommission,Hrsg.Neu-Isenburg:Med.MedienInformationsGmbH,p. 793Bundesgesundheitsamt(1981):Monographieentwürfefüranthroposophischeundphyto-therapeutischeArzneimittel.DtschApothZtg52:2910–2913

    Google Scholar 

  • CeglaUH(1988):Langzeittherapieüber2JahremitAmbroxol(Mucosolvan)RetardkapselnbeiPatientenmitchronischerBronchitis.ErgebnisseeinerDoppelblindstudiean180Patienten.PraxKlinPneumol42:715–721

    CAS  Google Scholar 

  • Celli BR, Decramer M, Wedzicha JA, Wilson KC, Augusti A, et al. (2015). An official Ameriocan Thoracis Society/>European Respiratory Society statement: reseach questions in COPD. Eur Respir J 45:879–905

    Article  PubMed  Google Scholar 

  • Cotgreave IA, Eklund A, Larsson K, Moldeus PW (1987): No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid. Eur J Respir Dis 70: 73–77

    CAS  PubMed  Google Scholar 

  • Cwientzek U, Ottillinger B, Arenberger P (2011): Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract. Phytomedicine 18: 1105–1109

    Article  PubMed  Google Scholar 

  • Decramer M, Rutten-van Molken M, Dekhuijzen PN, Troosters T, van Herwaarden C, Pellegrino R, van Schayck CP, Oliveri D, Del Donno M, De Backer W, Lankhorst I, Ardia A (2005): Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet365: 1552–1560

    Google Scholar 

  • Dicpinigaitis PV, Morice AH, Birrung SS, McGarvey L, Smith JA, Canning BJ, Page CP (2014): Antitussive drugs - past, present, and future. Pharmacol Rev 66: 468–512

    Article  CAS  PubMed  Google Scholar 

  • European Medicines Agency (2011): Community herbal monograph on Hedera helix L., folium. Final assessment report on Hedera helix L., folium. Internet: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/herbal/medicines/herbal_med_000115. jsp & mid=WC0b01ac058001fa1d

  • European Medicines Agency (2012): Opinion of the HMPC on a community herbal monograph on Hedera helix L., folium. Internet: http://www.ema-europa.eu/docs/en_GB/document_ library/Herbal_-_HMPC_opinion_on_Community_herbal_monograph/2012/01/WC500120649.pdf

  • European Medicines Agency (2015): Ambroxol and bromhexine expectorants: safety information to be updated. Press Release 25. February EMA/130676/2015.

    Google Scholar 

  • Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2010: Global Strategy for the Diag- nosis, Management and Prevention of COPD. Available from: http://www.goldcopd.org

  • Grandjean EM, Berthet PH, Ruffmann R, Leuenberger PH (2000): Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther 22: 209–221

    Google Scholar 

  • Guyatt GH, Townsend M, Kazim F, Newhouse MT (1987): A controlled trial of ambroxol in chronic bronchitis. Chest 92: 618–620

    Article  CAS  PubMed  Google Scholar 

  • Jones AP, Wallis C (2010): Dornase alfa for cystic fibrosis. Cochrane Database Syst Rev 2010 Mar 17; (3): CD001127

    Google Scholar 

  • Kayser O, Kolodziej H (1997): Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med 63: 508–510

    Article  CAS  PubMed  Google Scholar 

  • Kurz H (1986): Expektorantien und Antitussiva. Dtsch Apoth Ztg 126: 1024–1029

    Google Scholar 

  • Lemmer B (2000): Antitussiva und Expektorantien. In: Schwabe U, Paffrath D (Hrsg): Arzneiver- ordnungs-Report 2001, Springer-Verlag, Berlin Heidelberg, S. 234–256

    Google Scholar 

  • Lemmer B (2012): Antitussiva und Expektorantien. In: Schwabe U, Paffrath D (Hrsg): Arzneiver- ordnungs-Report 2012, Springer-Verlag, Berlin Heidelberg, S. 469-84

    Google Scholar 

  • Malerba M, Ponticiello A, Radaeli A, Bensi G, Grassi V (2004): Effect of twelve-months therapy with oral ambroxol in preventing exacerbations in patients with COPD. Double-blind, randomised, mulicenter, placebo-controlled study (the AMETHIST Trial). Pulm Pharmacol Therpeut 17: 27–34

    Google Scholar 

  • Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P (2013): Arzneimittelwirkungen, 10. Aufl., Wissenschaftliche Verlagsgesellschaft Stuttgart, S. 581–582

    Google Scholar 

  • Müller S, Jaffan L, Kloiber E, Läer S (2014): Dextrometorphan-Missbrauch bei Jugendlichen: Wie kann sich der Apotheker verhalten? Med Mo Pharm 37: 95–100

    Google Scholar 

  • Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh E.E. (2014): Honey for acute cough in children. Cochrane Database Syst Rev Dec 13;12:CD 007094.

    Google Scholar 

  • Olivieri D, Zavattini G, Tomasini G (1987): Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Respiration 51: Suppl 1, 42–51

    Article  PubMed  Google Scholar 

  • Olsson B, Johansson M, Gabrielsson J, Bolme P (1988): Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34: 77-82 0ymar K, Skjerven HO, Mikalsen IB (2014): Acute bronchiolitis in infants, a review. Scand J Trauma Resusc Emerg Med 22: 2–3

    Google Scholar 

  • Poole P, Black PN, Cates CJ. (2012): Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 15: 8: CD001287 Schmidt M, Thomsen M, Schmidt U (2012): Suitability of ivy extract for the treatment of paediatric cough. Phytother Res 26: 1942–1947

    Google Scholar 

  • Sharfstein JM, North M, Serwint JR (2007): Over the counter but no longer under the radar - pediatric cough and cold medications. N Engl J Med 357: 2321–2324

    Article  CAS  PubMed  Google Scholar 

  • Smith SM, Schroeder K, Fahey T (2008): Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev 1:CD0011831 Stauss-Grabo M, Atiye S, Warnke A, Wedemeyer RS, Donath F, Blume HH. (2010): Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan® Cough Tablets) in the treatment of colds accompanied by coughing. Phytomedicine. 15: 433–436

    Google Scholar 

  • Timmer A, Günther J, Rücker G, Motschall E, Antes G, Kern WV (2013): Pelargonium sidoides extract for acute respiratory tract infections. Cochrane Database Syst Rev. 2013 Oct 22; 1D: CD00632–3

    Google Scholar 

  • Tse HN, Raiteri L, Wong KY, Yee KS, Wai KY, Loo CK, Houng CM. (2013): High-Dose N-acetyl- cysteine in stable chronic obstructive pulmonary disease: the 1-year, double-blind, rand- omized, placebo-controlled HIACE study. Chest 144: 106–118

    Article  CAS  PubMed  Google Scholar 

  • Virchow JC, Backer V, de Blay F, Kuna P, Lj0rring C, Prieto JL, Villesen HH (2015): Defining moderate asthma exacerbations in clinical trials based on ATS/ERS joint statement. Resp Med 109: 547–556

    Google Scholar 

  • Wark P, McDonald VM (2009): Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev. 2009 Apr 15; (2): CD00150–6

    Google Scholar 

  • Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP (2013): Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2013 Jul 31; 7: CD006458 54–4

    Google Scholar 

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  1. Björn Lemmer
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    Lemmer, B. (2015). Antitussiva und Expektorantien. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2015. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47186-9_16

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    • DOI: https://doi.org/10.1007/978-3-662-47186-9_16

    • Publisher Name: Springer, Berlin, Heidelberg

    • Print ISBN: 978-3-662-47185-2

    • Online ISBN: 978-3-662-47186-9

    • eBook Packages: Medicine (German Language)

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