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Pathological Classification

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Pancreatic Cancer

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Abstract

Pancreatic neoplasms are morphologically and genetically heterogeneous and include a wide variety of tumors ranging from benign to malignant with an extremely poor clinical outcome. Over the past decade, there have been substantial improvements in our knowledge of pancreatic neoplasms and their precursor lesions. Extensive genetic analyses, recently using high-throughput molecular techniques and next-generation sequencing methodologies, have improved our understanding of the genetic basis of pancreatic neoplasms. In this chapter, the scheme we have adopted to classify neoplasms of the pancreas is based on the classification systems presented in the 2010 World Health Organization (WHO) “blue book” publication. In addition, we have added more recent improvements in our understanding of the biology, genetics, and clinical behavior of selected entities. As our knowledge grows, we fully anticipate that more new entities will be described and that new facets of previously described entities will be uncovered. It is our hope that the classification system presented will clarify clinical diagnoses and facilitate comparative studies on pancreatic neoplasia.

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  1. Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Room H 180B, Atlanta, GA, 30322, USA

    Yue Xue, Michelle D. Reid & Nazmi Volkan Adsay MD

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    Sun-Whe Kim

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    Hiroki Yamaue

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Xue, Y., Reid, M.D., Adsay, N.V. (2017). Pathological Classification. In: Kim, SW., Yamaue, H. (eds) Pancreatic Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47181-4_3

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