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The History and Evolution of Pancreaticoduodenectomy

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Pancreatic Cancer

Abstract

Pancreaticoduodenectomy (PD) is the procedure of choice for periampullary cancers, which include four separate malignancies occurring in the region of the ampulla of Vater: pancreatic ductal adenocarcinoma (PDAC), ampullary cancer, distal cholangiocarcinoma, and duodenal adenocarcinoma. The evolution of PD began as a series of isolated, independent resection attempts in the late 19th and early 20th centuries, but the procedure failed to gain momentum because of its great technical difficulty and dismal outcomes. Allen O. Whipple and colleagues were the first to adopt a systematic approach to radical pancreaticoduodenal resections and by 1935, they had demonstrated the technical feasibility of the procedure. However, the highly morbid operation was nearly abandoned altogether after postoperative outcomes failed to improve in the decades following Whipple’s initial success. Fortunately, a trend in centralization and standardization of care beginning in the 1980s fueled a decrease in perioperative mortality rates that now stands at 1-2% at high volume centers.

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Authors and Affiliations

  1. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA

    James F. Griffin & Christopher L. Wolfgang

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  1. James F. Griffin
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  2. Christopher L. Wolfgang
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Correspondence to Christopher L. Wolfgang .

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Editors and Affiliations

  1. Department of Surgery, Seoul National University, College of Medicine, Seoul, Korea (Republic of)

    Sun-Whe Kim

  2. Department of Surgery, Wakayama Medical University, Wakayama, Japan

    Hiroki Yamaue

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Griffin, J.F., Wolfgang, C.L. (2017). The History and Evolution of Pancreaticoduodenectomy. In: Kim, SW., Yamaue, H. (eds) Pancreatic Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47181-4_14

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  • DOI: https://doi.org/10.1007/978-3-662-47181-4_14

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