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Synergy Between Chemical Penetration Enhancers

  • Chapter
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

Synergistic combinations of chemical penetration enhancers are important considerations in drug formulation because they can greatly influence transdermal drug delivery, positively or negatively. This chapter describes how synergistic actions between chemical penetration enhancers can be defined, discovered and measured. The chapter considers literature reports where both positive and negative synergism between chemical penetration enhancers have been described. The underlying mechanisms of action that result in enhancer synergy are also discussed.

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Authors and Affiliations

  1. Department of Pharmaceutics, School of Pharmacy, University of Reading, Whiteknights, 226, Reading, RG6 6AP, UK

    Keng Wooi Ng, Wing Man Lau & Adrian C. Williams

Authors
  1. Keng Wooi Ng
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  2. Wing Man Lau
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  3. Adrian C. Williams
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Corresponding author

Correspondence to Adrian C. Williams .

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Editors and Affiliations

  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. Dermatology Clinic, University of California San Francisco Dermatology Clinic, San Francisco, USA

    Howard I. Maibach

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Ng, K.W., Lau, W.M., Williams, A.C. (2015). Synergy Between Chemical Penetration Enhancers. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_24

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  • DOI: https://doi.org/10.1007/978-3-662-47039-8_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47038-1

  • Online ISBN: 978-3-662-47039-8

  • eBook Packages: MedicineMedicine (R0)

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