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Peptide-Mediated Transdermal Drug Delivery

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Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

The skin offers an attractive interface for systemic delivery of drugs. Several physical and chemical approaches have been developed to overcome the natural transport barrier of the skin for therapeutically effective transdermal drug delivery. This chapter focuses on the use of peptides as novel transdermal drug delivery agents. Peptides offer several advantages over traditional methods in delivering drugs due to the ease of design and use, chemical diversity, and potentially low toxicity and immunogenicity. We discuss the potential of both the cell-penetrating and membrane-penetrating peptides in delivering a wide variety of cargoes ranging from proteins and peptide therapeutics, nanoparticles, and nucleotides across the skin. Although significant progress is evident, several challenges still remain. These are briefly discussed.

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Author information

Authors and Affiliations

  1. Department of Surgery, Research Scientist, SUNY Stony Brook, 069, Floor 19, Stony Brook, NY, 11794-8191, USA

    Gurtej Singh PhD

  2. Howard Isermann Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Rm. 3119, 110 8th St., Troy, NY, 12180, USA

    Pankaj Karande

Authors
  1. Gurtej Singh PhD
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  2. Pankaj Karande
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Corresponding author

Correspondence to Pankaj Karande .

Editor information

Editors and Affiliations

  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. Dermatology Clinic, University of California San Francisco Dermatology Clinic, San Francisco, USA

    Howard I. Maibach

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Singh, G., Karande, P. (2015). Peptide-Mediated Transdermal Drug Delivery. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47039-8_22

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  • DOI: https://doi.org/10.1007/978-3-662-47039-8_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47038-1

  • Online ISBN: 978-3-662-47039-8

  • eBook Packages: MedicineMedicine (R0)

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