Abstract
Basics and recent advances in blood vessel wall biomechanics are overviewed. The structure of blood vessel walls is first introduced with special reference to heterogeneity in the mechanical properties of artery walls at a microscopic level. Then basic characteristics of the mechanical properties of blood vessel walls are explained from the viewpoints of mechanical parameters used in clinical investigations, elastic and viscoelastic analysis, and effects of smooth muscle contraction. As examples of mechanical analysis of blood vessel walls, stress and strain analyses of artery walls as thin- and thick-walled cylinders, analyses considering residual stress and microscopic heterogeneity, are introduced. One of the most important topics in the blood vessel mechanics, mechanical responses and adaptations of blood vessel walls, is then discussed from the viewpoints of long- and short-term responses of artery walls to increases in blood pressure or flow. And finally, the importance of studying microscopic mechanical environment to elucidate these mechanical adaptations is pointed out.
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References
Wolinsky H, Glagov S (1967) A lamellar unit of aortic medial structure and function in mammals. Circ Res 20:99–111
Urry DW, Okamoto K, Harris RD, Hendrix CF, Long MM (1976) Synthetic, cross-linked polypentapeptide of tropoelastin: an anisotropic, fibrillar elastomer. Biochemistry 15:4083–4089
Fung YC, Sobin SS (1981) The retained elasticity of elastin under fixation agents. J Biomech Eng 103:121–122
Matsumoto T, Fukunaga A, Narita K, Nagayama K (2008) Microscopic mechanical analysis of aortic wall: estimation of stress in the intramural elastic laminas and smooth muscle cells in a physiological state. In: Proceedings of the 2008 summer Bioengineering conference (CD-ROM), 192450.pdf
Svendsen KH, Thomson G (1984) A new clamping and stretching procedure for determination of collagen fiber stiffness and strength relations upon maturation. J Biomech 17:225–229
Yamamoto N, Ohno K, Hayashi K, Kuriyama K, Yasuda K, Kaneda K (1993) Effects of stress shielding on the mechanical properties of patellar tendon. ASME J Biomech Eng 115:23–28
Matsumoto T, Nagayama K (2012) Tensile properties of vascular smooth muscle cells: bridging vascular and cellular biomechanics (review). J Biomech 45:745–755
Patel DJ, Fry DL (1969) The elastic symmetry of arterial segments in dogs. Circ Res 24:1–8
Schriefl AJ, Zeindlinger G, Pierce DM, Regitnig P, Holzapfel GA (2012) Determination of the layer-specific distributed collagen fiber orientations in human thoracic and abdominal aortas and common iliac arteries. J R Soc Interface 9:1275–1286
Roy S, Boss C, Rezakhaniha R, Stergiopulos N (2010) Experimental characterization of the distribution of collagen fiber recruitment. J Biorheol 24:84–93
Fischer GM, Llaurado JG (1966) Collagen and elastin content in canine arteries selected from functionally different vascular beds. Circ Res 19:394–399
Carew TE, Vaishnav RN, Patel DJ (1968) Compressibility of the arterial wall. Circ Res 23:61–68
Ohashi T, Sugita S, Matsumoto T, Kumagai K, Akimoto H, Tabayashi K, Sato M (2003) Rupture properties of blood vessel walls measured by pressure-imposed test. JSME Int J Ser C 46:1290–1296
Sugita S, Matsumoto T, Ohashi T, Kumagai K, Akimoto H, Tabayashi K, Sato M (2012) Evaluation of rupture properties of thoracic aortic aneurysms in a pressure-imposed test for rupture risk estimation. Cardiovasc Eng Technol 3:41–51
Patel D, Janicki J, Carew T (1969) Static anisotropic elastic properties of the aorta in living dogs. Circ Res 25:765–779
Biomechanical engineering: a first course. Japan Society of Mechanical Engineers, Maruzen, Tokyo (1997)
Bergel DH (1961) The static elastic properties of the arterial wall. J Physiol 156:445–457
Peterson L, Jensen R, Parnell R (1960) Mechanical properties of arteries in vivo. Circ Res 8:622–639
Hayashi K, Handa H, Nagasawa S, Okumura A, Moritake K (1980) Stiffness and elastic behavior of human intracranial and extracranial arteries. J Biomech 13:175–184
Bergel DH (1961) The dynamic elastic properties of the arterial wall. J Physiol 156:458–469
Cox RH (1979) Contribution of smooth muscle to arterial wall mechanics. Basic Res Cardiol 74:1–9
Dobrin PB, Rovick AA (1969) Influence of vascular smooth muscle on contractile mechanics and elasticity of arteries. Am J Physiol 217:1644–1652
Fung YC (1993) Chapter 7: Bioviscoelastic solids, and Chapter 8: Mechanical properties and active remodeling of blood vessels. In: Biomechanics: mechanical properties of living tissues, 2nd edn. Springer, New York
Humphrey JD (2002) Cardiovascular solid mechanics: cells, tissues, and organs. Springer, New York
Matsumoto T, Hayashi K (1996) Stress and strain distributions in hypertensive and normotensive rat aorta considering residual strain. ASME J Biomech Eng 118:62–73
Fung YC, Liu SQ (1989) Change of residual strains in arteries due to hypertrophy caused by aortic constriction. Circ Res 65:1340–1349
Matsumoto T, Tsuchida M, Sato M (1996) Change in intramural strain distribution in rat aorta due to smooth muscle contraction and relaxation. Am J Physiol Heart Circ Physiol 271:H1711–H1716
Vaishnav RN, Vossoughi J (1983) Estimation of residual strains in aortic segments. In: Hall CW (ed) Biomedical engineering II, recent developments. Pergamon Press, New York
Fung YC (1984) Section 2.9: The need for a new hypothesis for residual stress distribution. In: Biodynamics: circulation. Springer, New York
Takamizawa K, Hayashi K (1987) Strain energy density function and uniform strain hypothesis for arterial mechanics. J Biomech 20:7–17
Fung YC (1990) Chapter 11: Stress, strain and stability of organs. In: Biomechanics: motion, flow, stress, and growth. Springer, New York
Matsumoto T, Goto T, Sato M (2004) Microscopic residual stress caused by the mechanical heterogeneity in the lamellar unit of the porcine thoracic aortic wall. JSME Int J Ser A 47:341–348
Kamiya A, Togawa T (1980) Adaptive regulation of wall shear stress to flow change in the canine carotid artery. Am J Physiol 239:H14–H21
Masuda H, Zhuang YJ, Singh TM, Kawamura K, Murakami M, Zarins CK, Glagov S (1999) Adaptive remodeling of internal elastic lamina and endothelial lining during flow-induced arterial enlargement. Arterioscler Thromb Vasc Biol 19:2298–2307
Sugiyama T, Kawamura K, Nanjo H, Sageshima M, Masuda H (1997) Loss of arterial dilation in the reendothelialized area of the flow-loaded rat common carotid artery. Arterioscler Thromb Vasc Biol 17:3083–3091
Koller A, Sun D, Kaley G (1993) Role of shear stress and endothelial prostaglandins in flow-and viscosity-induced dilation of arterioles in vitro. Circ Res 72:1276–1284
Matsumoto T, Hayashi K (1994) Mechanical and dimensional adaptation of rat aorta to hypertension. J Biomech Eng 116:278–283
Wolinsky H (1971) Effects of hypertension and its reversal on the thoracic aorta of male and female rats. Circ Res 28:622–637
Wolinsky H (1972) Long-term effects of hypertension on the rat aortic wall and their relation to concurrent aging changes. Circ Res 30:301–309
Vaishnav RN, Vossoughi J, Patel DJ, Cothran LN, Coleman BR, Ison-Franklin EL (1990) Effect of hypertension on elasticity and geometry of aortic tissue from dogs. ASME J Biomech Eng 112:70–74
Berry C, Greenwald S (1976) Effects of hypertension on the static mechanical properties and chemical composition of the rat aorta. Cardiovasc Res 10:437–451
Furchgott RF (1983) Role of endothelium in responses of vascular smooth muscle. Circ Res 53:557–573
Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery. J Am Coll Cardiol 39:257–265
Anderson EA, Mark AL (1989) Flow-mediated and reflex changes in large peripheral artery tone in humans. Circulation 79:93–100
Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340:1111–1115
Cox DA, Vita JA, Treasure CB, Fish RD, Alexander RW, Ganz P, Selwyn AP (1989) Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans. Circulation 80:458–465
Fung YC (1997) Section 5.13: Local control of blood flow. In: Biomechanics: circulation, 2nd edn. Springer, New York
Bayliss WM (1902) On the local reactions of the arterial wall to changes of internal pressure. J Physiol 28:220–231
Matsumoto T, Nagayama K, Takezawa K, Masuda H (2008) US patent application no: 12/071873
Yaguchi T, Nagayama K, Tsukahara H, Masuda H, Matsumoto T (2013) Development of a non-invasive multifaceted evaluation system for arterial function under transmural pressure manipulation. International symposium on micro-nanomechatronics and human science (MHS2013). doi:10.1109/MHS.2013.6710460
Acknowledgements
This work was supported in part by the “Knowledge Hub” of AICHI, The Priority Research Project and JSPS KAKENHIs (nos. 22240055 and 24650295 for T.M., 24650256 and 26709002 for S.S., and 24700495 for T.Y.).
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Matsumoto, T., Sugita, S., Yaguchi, T. (2015). Biomechanics of Blood Vessels: Structure, Mechanics, and Adaptation. In: Niinomi, M., Narushima, T., Nakai, M. (eds) Advances in Metallic Biomaterials. Springer Series in Biomaterials Science and Engineering, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46836-4_4
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