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Injectable Tissue-Engineered Soft Tissue

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Innovations and Advances in Wound Healing

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Abstract

Autologous tissues including dermis and fat have long been used for soft tissue augmentation to correct facial wrinkles or skin contour defects. Additionally, given the advances in molecular biology and tissue engineering, soft tissue filler products are widely used. However, their variable degrees of resorption require repeated injections. To overcome these drawbacks, the author created a new injectable filler consisting of a mixture of hyaluronic acid filler and living autologous cells. In this chapter, the author’s basic research and clinical experiences with the tissue-engineered injectable soft tissue using cultured dermal fibroblasts, adipose-derived stromal vascular fraction cells and adipose-derived in vitro-differentiated adipocytes are presented. The injection of tissue-engineered soft tissue has many advantages. It is a simple procedure and can be carried out at an office without entering the operation room. Moreover, it almost eliminates communication errors between the physician and patient, because patients can immediately assess the results. In addition, patients feel more comfortable because autologous tissue is used.

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Authors and Affiliations

  1. Professor of Plastic Surgery, Director of Diabetic Wound Center, Director of Cell Therapy Laboratory, Korea University College of Medicine and Korea University Guro Hospital, Seoul, Republic of Korea (South Korea)

    Seung-Kyu Han

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  1. Seung-Kyu Han
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Han, SK. (2016). Injectable Tissue-Engineered Soft Tissue. In: Innovations and Advances in Wound Healing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46587-5_12

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  • DOI: https://doi.org/10.1007/978-3-662-46587-5_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-46586-8

  • Online ISBN: 978-3-662-46587-5

  • eBook Packages: MedicineMedicine (R0)

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