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NeuroIntensiv pp 253–266Cite as

Sepsis und Multiorganversagen

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Zusammenfassung

Sepsis, septischer Schock und sepsisinduziertes Multiorganversagen haben einen wesentlichen Anteil an der Mortalität von Patienten auf Intensivstationen. Trotz vieler Weiterentwicklungen auf dem Gebiet der Intensivmedizin hat sich die Letalität der Sepsis (35−70 %) in den letzten Jahren nicht wesentlich geändert. Die verschiedenen Aspekte der Pathophysiologie bei Sepsis sind Thema unzähliger Untersuchungen und Veröffentlichungen der letzten Jahre. Obwohl viele der so gewonnenen Erkenntnisse dazu beigetragen haben, das Krankheitsbild der Sepsis besser zu verstehen, haben nur wenige auch neue oder verbesserte Therapieansätze hervorgebracht. So sind das Zusammenspiel und die Bedeutung der verschiedenen Mediatoren des inflammatorischen Systems heute besser bekannt. Wesentliche therapeutische Optionen haben sich daraus bisher aber nicht ergeben. Ein wichtiger Bestandteil der Therapie bei Sepsis und Multiorganversagen ist daher nach wie vor eine adäquate und differenzierte Kreislauftherapie.

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Authors and Affiliations

  1. Klinik für Anästhesie, Intensivmedizin, Intensivtherapie und Schmerztherapie, HELIOS Klinikum Erfurt Gmbh, Nordhäuser Str. 74, 99089, Erfurt, Deutschland

    Gerald Burgard Dr.

  2. Klinik für Anästhesie, Intensivmedizin und Schmerztherapie, HELIOS Klinikum Erfurt GmbH, Nordhäuser Str. 74, 99089, Erfurt, Deutschland

    Andreas Meier-Hellmann Prof. Dr.

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  1. Andreas Meier-Hellmann Prof. Dr.
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  2. Gerald Burgard Dr.
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Correspondence to Andreas Meier-Hellmann Prof. Dr. .

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Editors and Affiliations

  1. Neurologische Klinik, Universitätklinikum Erlangen, Erlangen, Germany

    Stefan Schwab

  2. Neurologische Klinik und Geriatrie, Johannes Wesling Klinikum Minden, Minden, Germany

    Peter Schellinger

  3. Klinik für Anästhesiologie, Klinikum der Johannes-Gutenberg-Universität Mainz, Mainz, Germany

    Christian Werner

  4. Neurochirurgische Klinik, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany

    Andreas Unterberg

  5. Neurologische Klinik, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany

    Werner Hacke

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Meier-Hellmann, A., Burgard, G. (2015). Sepsis und Multiorganversagen. In: Schwab, S., Schellinger, P., Werner, C., Unterberg, A., Hacke, W. (eds) NeuroIntensiv. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46500-4_17

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  • DOI: https://doi.org/10.1007/978-3-662-46500-4_17

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