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Pain Control pp 239-260 | Cite as

The Role of Proteases in Pain

  • Jason J. McDougallEmail author
  • Milind M. Muley
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 227)

Abstract

Proteinase-activated receptors (PARs) are a family of G protein-coupled receptor that are activated by extracellular cleavage of the receptor in the N-terminal domain. This slicing of the receptor exposes a tethered ligand which binds to a specific docking point on the receptor surface to initiate intracellular signalling. PARs are expressed by numerous tissues in the body, and they are involved in various physiological and pathological processes such as food digestion, tissue remodelling and blood coagulation. This chapter will summarise how serine proteinases activate PARs leading to the development of pain in several chronic pain conditions. The potential of PARs as a drug target for pain relief is also discussed.

Keywords

Proteinase-activated receptor Pain Inflammation 

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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Departments of Pharmacology and Anaesthesia, Pain Management and Perioperative MedicineDalhousie UniversityHalifaxCanada

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