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Raman-Spektroskopie in der Dermatologie

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Nichtinvasive physikalische Diagnostik in der Dermatologie

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Zusammenfassung

Die Dermatologie ist ein geeignetes Fachgebiet, um optische und spektroskopische Untersuchungen zur Analyse der Haut, aber auch zur Penetration topisch applizierter Substanzen durchzuführen. Der Penetration topisch applizierter Substanzen in Form von Arzneimitteln und Pflegeprodukten kommt hierbei eine besondere Bedeutung zu. Während laserscanmikroskopische Untersuchungen hauptsächlich dazu dienen, die zelluläre Struktur abzubilden, wird mit Hilfe der Raman-Spektroskopie die inelastische Streuung von Licht an Molekülen oder Festkörpern erfasst. Damit ermöglicht die Raman-Spektroskopie den Nachweis von Stoffen in und auf der Haut. Hierbei wird Laserlicht in die Haut eingestrahlt. Neben der eingestrahlten Frequenz werden noch weitere Frequenzen beobachtet, deren Unterschiede zur Frequenz des eingestrahlten Lichts Informationen über die Rotationsschwingungs- und Photonen- oder Spin-Flip-Prozesse liefern. Mit den erhaltenen Spektren können Substanzen selektiv nachgewiesen werden.

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Authors and Affiliations

  1. Klinik für Dermatologie, Venerologie und Allergologie, Bereich Hautphysiologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland

    Jürgen Lademann Prof. Dr. med.

  2. Klinik für Dermatologie, Venerologie und Allergologie, Bereich Hautphysiologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland

    Martina C. Meinke PD Dr. rer. nat., Alexa Patzelt Dr. med. & Maxim E. Darvin Dr. rer. med.

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  1. Jürgen Lademann Prof. Dr. med.
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  2. Martina C. Meinke PD Dr. rer. nat.
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  3. Alexa Patzelt Dr. med.
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  4. Maxim E. Darvin Dr. rer. med.
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Editors and Affiliations

  1. Klinik für Dermatologie, Klinikum Augsburg Süd, Augsburg, Germany

    Julia Welzel

  2. Klinik für Dermatologie und Allergo, Ludwig-Maximilians-Universität, München, Germany

    Elke Sattler

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Lademann, J., Meinke, M.C., Patzelt, A., Darvin, M.E. (2016). Raman-Spektroskopie in der Dermatologie. In: Welzel, J., Sattler, E. (eds) Nichtinvasive physikalische Diagnostik in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46389-5_8

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