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Concept and Scientific Background of Personalized Medicine

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Book cover Personalized Treatment Options in Dermatology

Abstract

Tailoring a treatment to the special needs of a given individual has always been the overall goal in life and medical sciences. Progress in our understanding the pathophysiology and genetics of complex diseases has strongly contributed to consider many diseases under a new light and to project more sofisticated therapeutic approaches. Providing the right drug at the right dosis to the right patient the right time point is the substantial basis for personalized medicine, away from the classical, more or less evidence based “one size fits for all” model. Although the goal of personalized medicine sound obvious for all stakeholders, the way to reach it remains highly complex and needs the development of many different tools, including biobanks and the identification and validation of biomarkers. We will assist to a progressive change in our definition of the diseases, moving from the phenotypic taxonomy to a molecular taxonomy. The ultimate result will end in a more or less pronounced stratification of complex diseases into variable groups of patients, all characterized by various combinations of phenotypic and endophenotypic profiles. Moreover, this new medical evolutionary process will also induce a shift from the current curative medicine towards a more predictive, preventive, personalized and participatory (P4) medicine.

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References

  1. Spear BB, Heath-Chiozzi M, Huff J. Clinical application of pharmacogenetics. Trends Mol Med. 2001;7(5):201–4.

    Article  CAS  PubMed  Google Scholar 

  2. Roden DM, Tyndale RF. Genomic medicine, precision medicine, personalized medicine: what’s in a name? Clin Pharmacol Ther. 2013;94(2):169–72.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Bieber T. Stratified medicine: a new challenge for academia, industry, regulators and patients. London: Future Science; 2013.

    Book  Google Scholar 

  4. Shen B, Hwang J. The clinical utility of precision medicine: properly assessing the value of emerging diagnostic tests. Clin Pharmacol Ther. 2010;88(6):754–6.

    Article  CAS  PubMed  Google Scholar 

  5. Ross JS, Linette GP, Stec J, Clark E, Ayers M, Leschly N, et al. Breast cancer biomarkers and molecular medicine. Expert Rev Mol Diagn. 2003;3(5):573–85.

    Article  CAS  PubMed  Google Scholar 

  6. Eng C. Molecular genetics to genomic medicine practice: at the heart of value-based delivery of healthcare. Mol Genet Genomic Med. 2013;1(1):4–6.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Smart A, Martin P, Parker M. Tailored medicine: whom will it fit? The ethics of patient and disease stratification. Bioethics. 2004;18(4):322–42.

    Article  PubMed  Google Scholar 

  8. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160(4):636–45.

    Article  PubMed  Google Scholar 

  9. Bieber T, Cork M, Reitamo S. Atopic dermatitis: a candidate for disease-modifying strategy. Allergy. 2012;67(8):969–75.

    Article  CAS  PubMed  Google Scholar 

  10. Suarez-Farinas M, Shah KR, Haider AS, Krueger JG, Lowes MA. Personalized medicine in psoriasis: developing a genomic classifier to predict histological response to Alefacept. BMC Dermatol. 2010;10:1.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Broder S, Venter JC. Whole genomes: the foundation of new biology and medicine. Curr Opin Biotechnol. 2000;11(6):581–5.

    Article  CAS  PubMed  Google Scholar 

  12. Ocana A, Pandiella A. Personalized therapies in the cancer “omics” era. Mol Cancer. 2010;9:202.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Chen R, Snyder M. Promise of personalized omics to precision medicine. Wiley Interdiscip Rev Syst Biol Med. 2013;5(1):73–82.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Bieber T, Broich K. Personalised medicine. Aims and challenges. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013;56(11):1468–72.

    Article  CAS  PubMed  Google Scholar 

  15. Dorfman R, Khayat Z, Sieminowski T, Golden B, Lyons R. Application of personalized medicine to chronic disease: a feasibility assessment. Clin Transl Med. 2013;2(1):16.

    Article  PubMed Central  PubMed  Google Scholar 

  16. van den Broek M, Visser K, Allaart CF, Huizinga TW. Personalized medicine: predicting responses to therapy in patients with RA. Curr Opin Pharmacol. 2013;13(3):463–9.

    Article  PubMed  Google Scholar 

  17. Trusheim MR, Berndt ER, Douglas FL. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat Rev Drug Discov. 2007;6(4):287–93.

    Article  CAS  PubMed  Google Scholar 

  18. Olson JE, Bielinski SJ, Ryu E, Winkler EM, Takahashi PY, Pathak J, et al. Biobanks and personalized medicine. Clin Genet. 2014;86:50–5.

    Article  CAS  PubMed  Google Scholar 

  19. Suh KS, Sarojini S, Youssif M, Nalley K, Milinovikj N, Elloumi F, et al. Tissue banking, bioinformatics, and electronic medical records: the front-end requirements for personalized medicine. J Oncol. 2013;2013:368751.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Fernald GH, Capriotti E, Daneshjou R, Karczewski KJ, Altman RB. Bioinformatics challenges for personalized medicine. Bioinformatics. 2011;27(13):1741–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326(5960):1694–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324(5931):1190–2.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Momper JD, Wagner JA. Therapeutic drug monitoring as a component of personalized medicine: applications in pediatric drug development. Clin Pharmacol Ther. 2014;95(2):138–40.

    Article  CAS  PubMed  Google Scholar 

  24. Robison JE, Perreard L, Bernard PS. State of the science: molecular classifications of breast cancer for clinical diagnostics. Clin Biochem. 2004;37(7):572–8.

    Article  CAS  PubMed  Google Scholar 

  25. Bieber T. Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy. 2012;67(12):1475–82.

    CAS  PubMed  Google Scholar 

  26. Morgan XC, Huttenhower C. Chapter 12: Human microbiome analysis. PLoS Comput Biol. 2012;8(12):e1002808.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  27. Kesselheim AS, Shiu N. The evolving role of biomarker patents in personalized medicine. Clin Pharmacol Ther. 2014;95(2):127–9.

    Article  CAS  PubMed  Google Scholar 

  28. Schleidgen S, Marckmann G. Re-focusing the ethical discourse on personalized medicine: a qualitative interview study with stakeholders in the German healthcare system. BMC Med Ethics. 2013;14:20.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Phillips KA, Ann Sakowski J, Trosman J, Douglas MP, Liang SY, Neumann P. The economic value of personalized medicine tests: what we know and what we need to know. Genet Med. 2014;16(3):251–7.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Koelsch C, Przewrocka J, Keeling P. Towards a balanced value business model for personalized medicine: an outlook. Pharmacogenomics. 2013;14(1):89–102.

    Article  CAS  PubMed  Google Scholar 

  31. Hayes DF, Markus HS, Leslie RD, Topol EJ. Personalized medicine: risk prediction, targeted therapies and mobile health technology. BMC Med. 2014;12:37.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, et al. Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med. 2011;3(7):43.

    Article  PubMed Central  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology and Allergy, Center of Translational Medicine, University of Bonn, Sigmund Freud Str. 25, Bonn, 53105, Germany

    Thomas Bieber MD, PhD, MDRA

Authors
  1. Thomas Bieber MD, PhD, MDRA
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Correspondence to Thomas Bieber MD, PhD, MDRA .

Editor information

Editors and Affiliations

  1. Department of Dermatology and Allergy, Center of Translational Medicine, University of Bonn, Bonn, Germany

    Thomas Bieber

  2. St. John's Institute of Dermatology, London, United Kingdom

    Frank Nestle

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© 2015 Springer-Verlag Berlin Heidelberg

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Bieber, T. (2015). Concept and Scientific Background of Personalized Medicine. In: Bieber, T., Nestle, F. (eds) Personalized Treatment Options in Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45840-2_1

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  • DOI: https://doi.org/10.1007/978-3-662-45840-2_1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45839-6

  • Online ISBN: 978-3-662-45840-2

  • eBook Packages: MedicineMedicine (R0)

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