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Pemphigoid Gestationis

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Blistering Diseases

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Abstract

Pemphigoid gestationis is a rare autoimmune blistering disease of pregnancy involving autoantibodies targeting collagen XVII in the basement membrane zone of the skin. Patients usually present with pruritic urticarial papules and annular plaques eventually developing vesicles and tense bullae ranging from a few days to 4 weeks. The most common site for the lesions is the periumbilical area. Diagnosis is made by a high clinical suspicion on presentation and confirmed by histology and direct immunofluorescence. If required, indirect immunofluorescence, enzyme-linked immunosorbent assay, and immunoblotting may be done. Current management includes topical and systemic steroids, anti-inflammatory antibiotics, and immunosuppressives.

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Author information

Authors and Affiliations

  1. Department of Dermatology, St. George Hospital, Sydney, NSW, Australia

    Clarisse Garcia Mendoza MD, FPDS

  2. Department of Immunopathology, St. John’s Institute of Dermatology, London, UK

    Martin Munro Black MD, FRCP, FRC Path

  3. Department of Dermatology, St. George Hospital, University of NSW Medical School, Sydney, NSW, Australia

    Dédée F. Murrell MA(Camb),BMBCh(Oxf),FAAD,MD,FACD,FRCP

Authors
  1. Clarisse Garcia Mendoza MD, FPDS
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  2. Martin Munro Black MD, FRCP, FRC Path
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  3. Dédée F. Murrell MA(Camb),BMBCh(Oxf),FAAD,MD,FACD,FRCP
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Corresponding author

Correspondence to Dédée F. Murrell MA(Camb),BMBCh(Oxf),FAAD,MD,FACD,FRCP .

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Editors and Affiliations

  1. Department of Dermatology, St George Hospital, University of New South Wales, Sydney, New South Wales, Australia

    Dédée F. Murrell

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Mendoza, C.G., Black, M.M., Murrell, D.F. (2015). Pemphigoid Gestationis. In: Murrell, D. (eds) Blistering Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45698-9_32

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  • DOI: https://doi.org/10.1007/978-3-662-45698-9_32

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