Abstract
Regional homogeneity (ReHo) is widely used in the analysis of fMRI data of patients with schizophrenia. However, the influence of scan duration on the results is not clear. In this work, intraclass correlation coefficient (ICC) was applied to investigate the reliability of a popular method called KCC-ReHo algorithm, using rest-state fMRI data of schizophrenia patients. The full length 6 minutes data collected was split into data with six different durations from 1 min to 6 min with 1 min equal separation. With increasing scan duration, the mean ICC value of the whole brain is found to increase monotonically from 0.55 to 0.97, and the standard deviation decreases from 0.21 to 0.02. The high ICC values mainly occurred in the superior parietal gyrus, paracentral lobule, superior frontal gyrus dorsolateral, supplementary motor area, fusiform gyrus and inferior temporal gyrus of both hemispheres.
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References
Biswal, B., Zerrin Yetkin, F., et al.: Functional connectivity in the motor cortex of resting human brain using echo‐planar mri. Magnetic Resonance in Medicine 34(4), 537–541 (1995)
Lang, S., Duncan, N., et al.: Resting-State Functional Magnetic Resonance Imaging: Review of Neurosurgical Applications. Neurosurgery 74(5), 453–465 (2014)
Karbasforoushan, H., Woodward, N.D.: Resting-State Networks in Schizophrenia. Current Topics In Medicinal Chemistry 12(21), 2404–2414 (2012)
Liu, H., Kaneko, Y., et al.: Schizophrenic patients and their unaffected siblings share increased resting-state connectivity in the task-negative network but not its anticorrelated task-positive network. Schizophr Bull. 38(2), 285–294 (2012)
Yu, Q., Allen, E.A., et al.: Brain connectivity networks in schizophrenia underlying resting state functional magnetic resonance imaging. Current Topics In Medicinal Chemistry 12(21), 2415–2425 (2012)
Lopez-Larson, M.P., Anderson, J.S., et al.: Local brain connectivity and associations with gender and age. Developmental Cognitive Neuroscience 1(2), 187–197 (2011)
Dai, X.J., Gong, H.H., et al.: Gender differences in brain regional homogeneity of healthy subjects after normal sleep and after sleep deprivation: a resting-state fMRI study. Sleep Medicine 13(6), 720–727 (2012)
Wang, L., Song, M., et al.: Regional homogeneity of the resting-state brain activity correlates with individual intelligence. Neuroscience Letters 488(3), 275–278 (2011)
Zuo, X.N., Di Martino, A., et al.: The oscillating brain: complex and reliable. Neuroimage 49(2), 1432–1445 (2010)
Yan, C.G., Zang, Y.: DPARSF: a MATLAB toolbox for pipeline data analysis of resting-state fMRI. Frontiers in Systems Neuroscience 4 (2010)
Zang, Y., Jiang, T., et al.: Regional homogeneity approach to fMRI data analysis. NeuroImage 22(1), 394–400 (2004)
Zuo, X.N., Xing, X.: Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: a systems neuroscience perspective. Neuroscience & Biobehavioral Reviews (2014)
Zhu, P., Liu, X.Y., et al.: fMRI analysis of schizophrenic patients with aggressive behavior. In: Chinese Automation Congress(CAC), 675–678. IEEE (2013)
Tian, L., Ren, J., et al.: Regional homogeneity of resting state fMRI signals predicts Stop signal task performance. NeuroImage 60(1), 539–544 (2012)
Birn, R.M., Molloy, E.K., et al.: The effect of scan length on the reliability of resting-state fMRI connectivity estimates. NeuroImage 83, 550–558 (2013)
Zuo, X.-N., Xu, T., et al.: Toward reliable characterization of functional homogeneity in the human brain: Preprocessing, scan duration, imaging resolution and computational space. NeuroImage 65, 374–386 (2013)
Yi, J.L., Wang, X.P., et al.: Magnetic resonance imaging study of smygdala functional connectivity pattern of male schizophrenic patients with aggressive behavior. Chinese Journal of Clinical Psychology 17(6), 669–671 (2009)
Shrout, P.E., Fleiss, J.L.: Intraclass correlations: uses in assessing rater reliability. Psychol. Bull. 86(2), 420–428 (1979)
Landis, J.R., Koch, G.G.: The measurement of observer agreement for categorical data. Biometrics 33(1), 159–174 (1977)
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Li, X., Zhou, J., Liu, X. (2014). Influence of Scan Duration on the Reliability of Resting-State fMRI Regional Homogeneity. In: Li, S., Liu, C., Wang, Y. (eds) Pattern Recognition. CCPR 2014. Communications in Computer and Information Science, vol 484. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45643-9_42
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DOI: https://doi.org/10.1007/978-3-662-45643-9_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-45642-2
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