Abstract
Saliva, crucial to the function and protection of the oral cavity, has recently become also a “diagnostic fluid.” Protein composition and function of saliva are altered during disease, allowing it to become a medium in detection of many systemic illnesses. Furthermore, its safe and noninvasive collection makes saliva an ideal specimen over blood. To appreciate the role of salivary proteomics in predicting disease, saliva’s production, composition, and excretion in health must be understood. A summary of salivary gland anatomy, histology, saliva formation, and secretion is reviewed in this chapter.
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References
Etzel K. Role of salivary glands in nutrition. In: Dobrosielski-Vergona K, editor. Biology of the salivary glands. Boca Raton: CRC Press, Inc; 1993. p. 129–52.
Holsinger CF, Bui DT. Anatomy, function, and evaluation of the salivary glands. In: Myers EN, Ferris RL, editors. Salivary gland disorders. Berlin/Heidelberg: Springer; 2007. p. 1–16.
Edgar WM. Saliva and dental health: clinical implications of saliva: report of a consensus meeting. Br Dent J. 1990;169(3–4):96–8.
Fox PC, van der Ven PF, Sonies BC, Weiffenbach JM, Baum BJ. Xerostomia: evaluation of a symptom with increasing significance. JADA. 1985;110:519–25.
Bardow A, Lagerlof F, Nauntofte B, Tenovuo J. The role of saliva. In: Fejerskov O, Kidd E, editors. Dental caries: the disease and its clinical management. 2nd ed. Singapore: Wiley; 2008. p. 190–207.
Nanci A. Salivary glands. In: Ten Cate’s oral histology. 8th ed. Nanci A, Development, structure, and function. St. Louis: Elsevier; 2013. p. 253–77.
Roth G, Calmes R. Salivary glands and saliva. In: Oral biology. Eds. Roth G and Calmes R, St Louis: CV Mosby; 1981. p. 196–236.
McNabb PC, Tomasi TB. Host defense mechanisms at mucosal surfaces. Annu Rev Microbiol. 1981;35:477–96.
Dowd FJ. Saliva and dental caries. Dent Clin North Am. 1999;43:579–97.
Matsuo R. Role of saliva in the maintenance of taste sensitivity. Crit Rev Oral Biol Med. 2000;11(2):216–29.
Tabak LA, Levine MJ, Mandel ID, Ellison SA. Role of salivary mucins in the protection of the oral cavity. J Oral Pathol. 1982;11:1–17.
Saracco CG, Crabill EV. Anatomy of the human salivary glands. In: Dobrosielski-Vergona K, editor. Biology of the salivary glands. Boca Raton: CRC Press, Inc; 1993. p. 1–14.
Sreebny LM. Dry mouth and salivary gland hypofunction, part I: diagnosis. Compendium. 1988;9(7):569–70. 573–4, 576 passim.
Nagato T, Yoshida H, Yoshida A, Uehara Y. A scanning electron microscope study of myoepithelial cells in exocrine glands. Cell Tissue Res. 1980;209(1):1–10.
Nauntofte B. Regulation of electrolyte and fluid secretion in salivary acinar cells. Am J Physiol. 1992;263(6):823–37.
Turner RJ, Sugiya H. Understanding salivary fluid and protein secretion. Oral Dis. 2002;8(1):3–11.
Catalán MA, Nakamoto T, Melvin JE. The salivary gland fluid secretion mechanism. J Med Invest. 2009;56(Suppl):192–6.
Petersen OH. Calcium-activated potassium channels and fluid secretion by exocrine glands. Am J Physiol. 1986;25:G1–13.
Hay DI, Smith DJ, Schluckebier SK, Moreno EC. Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva. J Dent Res. 1984;63(6):857–63.
García-Godoy F, Hicks MJ. Maintaining the integrity of the enamel surface. The role of dental biofilm, saliva and preventive agents in enamel demineralization and remineralization. JADA. 2008;139(2):25S–34.
Fine DH, Furgang D, Beydouin F. Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitis. J Periodontol. 2002;73(6):624–30.
Valenti P, Berlutti F, Conte MP, Longhi C, Seganti L. Lactoferrin functions: current status and perspectives. J Clin Gastroenterol. 2004;38(6):S127–9.
Walz A, Stühler K, Wattenberg A, Hawranke E, Meyer HE, Schmalz G, et al. Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by two-dimensional gel electrophoresis. Proteomics. 2006;6(5):1631–9.
Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG. Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches. J Biol Chem. 2003;278(7):5300–8. 14.
Malamud D, Abrams WR, Barber CA, Weissman D, Rehtanz M, Golub E. Antiviral activities in human saliva. Adv Dent Res. 2011;23(1):34–7.
Pfaffe T, Cooper-White J, Beyerlein P, Kostner K, Punyadeera C. Diagnostic potential of saliva: current state and future applications. Clin Chem. 2011;57(5):675–87.
Acknowledgments
The authors would like to thank the following colleagues:
Dr. Streckfus for his continuous mentorship
Dr. Barry Rittman for his gracious support of this chapter by providing all the histology pictures
Dedication
Shalizeh A. Patel
To my parents: for all the sacrifices they’ve made for me
To my husband: for loving me unconditionally
To my daughters: for making life so beautiful
Juliana A. Barros
To my Dad for encouraging and supporting my dreams
To my husband and kids for making life meaningful
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Patel, S.A., Barros, J.A. (2015). Introduction. In: Streckfus, C. (eds) Advances in Salivary Diagnostics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45399-5_1
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DOI: https://doi.org/10.1007/978-3-662-45399-5_1
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