Abstract
This study is to detect the flow field characters of NIVAD and the hemolysis test in vitro and to evaluate the hemodynamic performance and the influence on calves. The flow field characters of NIVAD were calculated by CFD. In hemolysis test in vitro, controlled flow of NIVAD 5 L/min and the outflow tract pressure 100 mmHg, the plasma free hemoglobin (FHB) content and the hematocrit (HCT) were measured at 0, 0.5, 1, …4 hours. Then NIH (Normal Index of Hemolysis) of NIVAD was calculated. In vivo experiments, NIVAD was implanted in 8 calves. Physiological index and biochemical data of serum were taken during the experiments. The nephograms show the speed and pressure change of NIVAD flow field by CFD. The hemolysis, which was evaluated by NIH was 0.065±0.014mg/L in vitro, by FHB was below 10 mg/dl in vivo. There was no obvious thrombus and adverse events on the animals and pumps. Biochemical data of serum evaluation showed that implantation of NIVAD in calves did not impair end organ function. Gross and microscopic sections of kidney, liver, and lung revealed no evidence of microemboli, edma or infracts. The index of NIVAD satisfy the request of clinic use. The results of experiments in vitro and in vivo lay foundations for clinic use in future.
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References
Kwon, M.H., Moriguchi, J.D., Ardehali, A., et al.: Use of ventricular assist device as a bridge to cardiac transplantation: impact of age and other determinants on outcomes. J. Tex. Heart. Inst. 36, 214–219 (2009)
Fan, H.M., Hong, F.W., Zhang, G.P., et al.: Application of CFD techniques in the design and flow analysis of implantable axial flow blood pump. J. Hydrodynamics 22, 518–525 (2002)
Fan, H.M., Hong, F.W., Zhou, L.D., et al.: Design of implantable axial- flow blood pump and numerical studies on its performance. J. Hydrodynamics 21, 445–452 (2009)
Tuzun, E., Eya, K., Chee, H.K., et al.: Myocardial hemodynamics, physiology, and perfusion with an axial flow left ventricular aAssist device in the calf. J. ASAIO 50, 47–53 (2004)
Frazier, O.H., Cohn, W.E., Tuzun, E., et al.: Continuous-Flow total artificial heart supports long-term survival of a calf. J. Tex. Heart. Inst. 36, 568–574 (2009)
Hoshi, H., Shinshi, T., Takatani, S.: Third generation blood pumps with mechanical non-contact magnetic bearing. J. Artif. Organs. 30, 324–339 (2006)
Nojiri, C., Kijima, T., Maekawa, J., et al.: Development status of Terumo implantable left ventricular assist system. J. Artif. Organs. 25, 411–413 (2001)
Asama, J., Shinshi, T., Hoshi, H., et al.: A compact highly efficient and low hemolytic centrifugal blood pump with a magnetically levitated impeller. J. Artif. Organs. 30, 160–167 (2006)
Zhang, J., Gellman, B., Koert, A., et al.: Computational and experimental evaluation of the fluid dynamics and hemocompatibility of the CentriMag blood pump. J. Artif. Organs. 30, 168–177 (2006)
Fossum, T.W., Morley, D., Benkowski, R., et al.: Chronic survival of calves implanted with the Debakey ventricular assist device. J. Artif. Organs. 23, 802–806 (1999)
Kerkhoffs, W., Schumacher, O., Meyns, B., et al.: Design, development, and first in vivo results of an implantable ventricular assist device, MicroVad. J. Artif. Organs. 28, 904–910 (2004)
Ye, L., Fan, H.M., Lu, R., et al.: Establishment of an animal model for implantable ventricular assist device. J. Acta. Lab. Anim. Sci. Sin. 17, 457–459 (2009)
Li, T.Y., Ye, L., Zhang, Z.G., et al.: The hemolysis research of the national implantable ventricular assist device. J. Tongji. Uni (Med. Sci.) 32, 47–50 (2011)
Fan, H.M., Lu, R., Liu, Z.M.: Experimental study of domestic implantable ventricular assist device. J. Tongji. Uni (Med. Sci.) 27, 6–9 (2006)
Kirklin, J.K., Holman, W.L.: Mechanical circulatory support therapy as a bridge to transplant or recovery (new advances). J. Curr. Opin. Cardiol. 21, 120–126 (2006)
Takahama, T., Kanai, F., Onishi, K.: Anticoagulation during use of a left ventricular assist device. J. ASAIO 46, 354–357 (2000)
Schmitto, J.D., Ortmann, P., Akdis, M., et al.: Miniaturized HIA microdiagonal pump as left ventricular assist device in a sheep model. J. ASAIO 54, 233–236 (2008)
Carney, E.L., Clark, J.B., Myers, J.L., et al.: Animal model development for the Penn State Pediatric ventricular assist device. J. Artif. Organs. 33, 953–957 (2009)
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Li, T., Ye, L., Lu, R., Fan, H., Liu, Z. (2014). Circulation System Modelling with National Implantable Ventricular Assist Device (NIVAD): Hydrodynamic Characters, Hemolysis Test in Vitro and Animal Experiments. In: Ma, S., Jia, L., Li, X., Wang, L., Zhou, H., Sun, X. (eds) Life System Modeling and Simulation. ICSEE LSMS 2014 2014. Communications in Computer and Information Science, vol 461. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45283-7_25
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DOI: https://doi.org/10.1007/978-3-662-45283-7_25
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