Skip to main content
SpringerLink
Log in
Book cover

Peste des Petits Ruminants Virus pp 119–131Cite as

Pathology of Peste des Petits Ruminants Virus Infection in Small Ruminants and Concurrent Infections

  • Chapter
  • First Online:

  • 801 Accesses

Abstract

Peste des petits ruminant (PPR) is a systemic viral disease of goats and sheep characterized by gastrointestinal and respiratory system lesions with high rate of mortality. Rhinitis, conjunctivitis, serous-mucopurulent naso-ocular discharge, pneumonia, coughing, dispnea, erosive–ulcerative oral lesions, and diarrhea are the most prominent clinicopathological features of the disease. Histopathologically, pseudomembraneous stomatitis, necrotic tonsillitis, fibrinohemorrhagic enteritis, and proliferative interstitial pneoumonia are seen. Syncytial cells and cytoplasmic and/or nuclear eosinophilic inclusion bodies are considered as pathognomonic. Like the other morbilli viruses, PPR virus can also cause lesions in the kidney, brain, and abomasum. The PPRV tropism can be explained by the mechanism in which PPRV binds to receptors on the cell surface. The PPR in small ruminants often shows co-association with secondary viral, bacterial, and parasitary infections.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abu Elzein EME, Housawi FMT, Bashareek Y, Gameel AA, Al-Afaleq AI, Anderson E (2004) Severe PPR infection in gazelles kept under semi-free range conditions. J Vet Med B 51:68–71

    Article  Google Scholar 

  • Abubakar M, Qurban A, Khan HA (2007) Prevalance and mortality rate of peste des petits ruminants: possible association with abortion in goat. Trop Anim Health Prod 40:317–321

    Article  Google Scholar 

  • Alcigir G, Vural S, Toplu N (1996) Erstepathomorphologische und immunhistologichebeschreibung der peste des petitsruminantsbei den lammern in der Turkei. Ankara Univ Vet Fak Derg 43:181–189

    Google Scholar 

  • Amjad H, Qamar-ul-Islam A, Forsyt M, Barrett T, Rossiter PB (1996) Peste des petits ruminants in goats in Pakistan. Vet Rec 139:118–119

    Article  CAS  PubMed  Google Scholar 

  • Aruni AW, Lalitha PS, Mohan AC, Chitravelu P, Anbumani SP (1998) Histopathological study of a natural outbreak of peste des petits ruminants in goats of Tamilnadu. Small Ruminant Res 28:233–240

    Article  Google Scholar 

  • Atmaca HT, Kul O (2012) Examination of epithelial tissue cytokine response to natural peste des petits ruminants virus (PPRV) infection in sheep and goats by immunohistochemistry. HistolHistopathol 27:69–78

    CAS  Google Scholar 

  • Bailey D, Banyard A, Dash P, Ozkul A, Barrett T (2005) Full genome sequence of peste des petitsruminants virus, a member of the Morbillivirus genus. Virus Res 110:119–124

    Article  CAS  PubMed  Google Scholar 

  • Brown CC, Mariner JC, Olander HJ (1991) An immunohistochemical study of the pneumonia caused by peste des petits ruminants virus. Vet Pathol 28:166–170

    Article  CAS  PubMed  Google Scholar 

  • Bundza A, Afshar A, Dukes WD, Myers DJ, Dulac GC, Becker SAW (1988) Experimental peste des petits ruminants (goat plaque) in goats and sheeps. Can J Vet Res 52:46–52

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chinnakannan SK, Nanda SK, Baron MD (2013) Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. PLoS One 8(2). doi:10.1371/journal.pone.0057063

  • Diallo A (1988) Rinderpest and peste des petits ruminants; constant threats to animal farming in many developing countries. Impact Sci Soc 150:179–192

    Google Scholar 

  • Emikpe BO, Sabri MY, Akpayie SO, Zamri-Saad M (2010) Experimental infection of peste des Petit Ruminant virus and Mannheimia haemolytica A2 in goats: immunolocalisation of Mannheimia haemolytica antigens. Vet Res Commun 34:569–578

    Article  PubMed  Google Scholar 

  • Galbraith SE, McQuaid S, Hamill L, Pullen L, Barrett T, Cosby SL (2002) Rinderpest and peste des petits ruminants viruses exhibit neurovirulence in mice. J Neurovirol 8:45–52

    Article  PubMed  Google Scholar 

  • Gibbs EPJ, Taylor WP, Lavman MJP, Bryant J (1979) Classification of peste des petitsruminants virus as the fourth member of genus Morbillivirus. Intervirology 11:268–274

    Article  CAS  PubMed  Google Scholar 

  • Gulyaz V, Ozkul A (2005) Pathogenicity of a local peste des petits ruminants virus isolate in sheep in Turkey. Trop Anim Health Pro 37:541–547

    Article  CAS  Google Scholar 

  • Hammouchi M, Loutfi C, Sebbar G, Touil N, Chaffai N, Batten C, Harif B, Oura C, El Harrak M (2012) Experimental infection of alpine goats with a Moroccan strain of peste des petits ruminants virus (PPRV). Vet Microbiol 160:240–244

    Article  PubMed  Google Scholar 

  • Jagtap SP, Rajak KK, Garg UK, Sen A, Bhanuprakash V, Sudhakar SB, Balamurugan V, Patel A, Ahuja A, Singh RK, Vanamaya PR (2012) Effect of immunosuppression on pathogenesis of peste des petits ruminants (PPR) virus infection in goats. Microb Pathog 52:217–226

    Article  PubMed  Google Scholar 

  • Kennedy S, Smyth JA, Cush PF, Duignan P, Platten M, McCullough SJ, Allan GM (1989) Histopathologic and immunohistochemical studies of distemper in seals. Vet Pathol 26:97–103

    Article  CAS  PubMed  Google Scholar 

  • Kennedy S, Smyth JA, Cush PF, McAliskey M, McCullough SJ, Rima BK (1991) Histopathologic and immunohistochemical studies of distemper in harbor porpoises. Vet Pathol 28:97–103

    Article  Google Scholar 

  • Kul O, Kabakci N, Atmaca HT, Ozkul A (2007) Natural peste des petits ruminants virus infection: Novel pathological findings resembling other Morbillivirus infections. Vet Pathol 44:479–486

    Article  CAS  PubMed  Google Scholar 

  • Kul O, Kabakci N, Özkul A, Kalender K, Atmaca HT (2008) Concurrent peste des petits ruminants virus and pestivirus infection in stillborn twin lambs. Vet Pathol 45:2

    Article  Google Scholar 

  • Kul O, Toplu N, Atmaca HT (2012) Peste des petits ruminants in Turkey and Pakistan: investigation on the pathogenesis and vertical transmission of peste des petits ruminants in naturally infected sheep and goat flocks. Scientific Project Report, Project No.: 108O706, Turkish Scientific Research Council

    Google Scholar 

  • Kulkarni DD, Bhikane MS, Shaila MS, Varalakshmi P, Apte MP, Narladkar BW (1996) Peste des petits ruminants in goats India. Vet Rec 138:187–188

    Article  CAS  PubMed  Google Scholar 

  • Kumar P, Tripathi BN, Sharma AK, Kumar R, Sreenivasa BP, Singh RP, Dhar P, Bandyopadhyay SH (2004) Pathological and immunohistochemical study of experimental peste des petits ruminants virus infections in goats. J Vet Med B 51:153–159

    Article  CAS  Google Scholar 

  • Malik YS, Singh D, Chandrashekar KM, Shukla S, Sharma K, Vaid N, Chakravarti S (2011) Occurrence of dual infection of peste-des-petits-ruminants and goatpox in indigenous goats of central India. Transbound Emerg Dis 58:268–273

    Article  CAS  PubMed  Google Scholar 

  • Obi TU, Ojo MO, Durojaiye OA, Kasali OB, Akparie S, Opasina DB (1983) Peste des petits ruminants in goats in Nigeria: clinical, microbiological and pathological features. Zentralblatt fur VeterinaerMedizin B 30:751–761

    Article  CAS  Google Scholar 

  • Ozkul A, Akca Y, Alkan F, Barrett T, Karaoglu T, Dagalp SB, Anderson J, Yesilbag K, Cokcalıskan C, Gencay A, Burgu I (2002) Prevalence, distribution, and host range of peste des petits ruminants virus, Turkey. Emerg Infect Dis 8:708–712

    Article  PubMed  Google Scholar 

  • Perl S, Alexander A, Yakobson B, Nyska A, Harmelin A, Abramson M, Rapaport E (1994) Peste des petits ruminants of sheep in Israel. Case report. Isr J Vet Med 49:59–62

    Google Scholar 

  • Plowright W (1968) Virology monographs 3: rinderpest virus. Springer, New York/Vienna, pp 25–110

    Google Scholar 

  • Rajak KK, Sreenivasa BP, Hosamani M, Singh RP, Singh SK, Singh RK, Bandyopadhyay SK (2005) Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats. Comp Immunol Microbiol 28:287–296

    Article  CAS  Google Scholar 

  • Saravanan P, Balamurugan V, Sen A, Sarkar J, Sahay B, Rajak KK, Hosamani M, Yadav P, Singh RK (2007) Mixed infection of peste des petits ruminants and orf on a goat farm in Shahjahanpur, India. Vet Rec 160:410–412

    Article  CAS  PubMed  Google Scholar 

  • Taylor WP, Diallo A, Gopalakrishna S, Sreeramalu P, Wilsmore AJ, Nanda YP, Libeau G, Rajasekhar M, Mukhopadhay AK (2002) Peste des petits ruminants has been widely present in southern India since, if not before, the late 1980s. Prev Vet Med 52:305–312

    Article  CAS  PubMed  Google Scholar 

  • Toplu N (2004) Characteristic and non-characteristic pathological findings in peste des petits ruminants (PPR) of sheep in the Ege district of Turkey. J Comp Pathol 131:135–141

    Article  CAS  PubMed  Google Scholar 

  • Toplu N, Oguzoglu TC, Albayrak H (2012) Dual infection of fetal and neonatal small ruminants with border disease virus and peste des petits ruminants virus (PPRV): neuronal tropism of PPRV as a novel finding. J Comp Path 146:289–297

    Article  CAS  PubMed  Google Scholar 

  • Ugochukwu EI, Agwu CO (1991) Aerobic bacteria from nasal discharge of goats suffering from clinical PPR: isolation and identification. Microbios 65(263):81–85

    CAS  PubMed  Google Scholar 

  • Wohlsein P, Saliki JT (2006) Rinderpest and peste des petits ruminants—the diseases: Clinical signs and pathology. In: Barrett T, Pastoret P-P, Taylor WP (eds) Rinderpest and peste des petits ruminants. Academic Press, New York, pp 68–85

    Chapter  Google Scholar 

  • Yesilbag K, Yilmaz Z, Golcu E, Ozkul A (2005) Peste des petits ruminants outbreak in western Turkey. Vet Rec 27:260

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkiye

    Oguz Kul & Hasan Tarık Atmaca

  2. The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK

    Muhammad Munir

Authors
  1. Oguz Kul
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hasan Tarık Atmaca
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Muhammad Munir
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Oguz Kul .

Editor information

Editors and Affiliations

  1. The Pirbright Institute, Pirbright, Surrey, United Kingdom

    Muhammad Munir

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kul, O., Atmaca, H.T., Munir, M. (2015). Pathology of Peste des Petits Ruminants Virus Infection in Small Ruminants and Concurrent Infections. In: Munir, M. (eds) Peste des Petits Ruminants Virus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45165-6_7

Download citation

Publish with us

Policies and ethics

Search

Navigation