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Drug-Induced Pemphigus

  • Chapter
European Handbook of Dermatological Treatments

Abstract

Pemphigus comprises a group of autoimmune bullous diseases characterized by acantholysis (loss of adhesion between keratinocytes) that results in the formation of intraepithelial blisters in skin and mucous membranes. Drug-induced pemphigus (DIP) is a rare but well-established type of pemphigus, Multiple drugs are reported to induce pemphigus, most commonly thiol drugs. The mechanisms include autoantibody formation and direct acantholysis. Withdrawal of an offending drug may lead to remission or reduced disease severity in many patients.

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Abbreviations

HLA:

Human leukocyte antigen

IL-1:

Interleukin-1

TNF-α:

Tumour necrosis factor alpha

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Author information

Authors and Affiliations

  1. University Hospitals, Leicester, UK

    Olga Golberg & Karen Elizabeth Harman

Authors
  1. Olga Golberg
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  2. Karen Elizabeth Harman
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Editor information

Editors and Affiliations

  1. Department of Dermatology, Andreas Syggros Hospital University of Athens, Athens, Greece

    Andreas D. Katsambas  & Clio Dessinioti  & 

  2. University of Rome “G. Marconi”, Rome, Italy

    Torello M. Lotti

  3. Centro Studi per la Ricerca Multidisciplinare Rigenerativa (CSRMR), Rome, Italy

    Torello M. Lotti

  4. Unit of Dermatology, University of Pisa, Pisa, Italy

    Angelo Massimiliano D’Erme

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Golberg, O., Harman, K.E. (2015). Drug-Induced Pemphigus. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D’Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45139-7_72

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  • DOI: https://doi.org/10.1007/978-3-662-45139-7_72

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45138-0

  • Online ISBN: 978-3-662-45139-7

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