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Necrobiosis Lipoidica

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European Handbook of Dermatological Treatments

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Abstract

Necrobiosis lipoidica (NBL) presents as solitary or multiple chronic granulomatous infiltrative lesions of unknown etiology in the dermis of predominantly female patients. It has a higher prevalence in diabetic patients, but the association between NBL and diabetes is debated.

Microangiopathy and tissue hypoxia may play a leading role in the pathogenesis; ulceration and infection may contribute to persistence. Possibility of genetic predisposition might be of importance as well as oncogene expression. Treatment is difficult, often resulting only in partial response and frequent relapses. Topically applied steroids or calcineurin inhibitors in combination with compression serve as baseline therapy, while various forms of phototherapy come as second line. New approaches emerge, such as photodynamic therapy and fractional laser therapy, local fumaric acid ester, intravenous immunoglobulin, and systemic targeted therapy with biologicals, but their effectiveness needs to be further evaluated.

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Abbreviations

DM:

Diabetes mellitus

NBL:

Necrobiosis lipoidica

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Authors and Affiliations

  1. Department of Dermatology, Clinical Center, University of Debrecen, Debrecen, Hungary

    Istvan Juhasz

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  1. Istvan Juhasz
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Correspondence to Istvan Juhasz .

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Editors and Affiliations

  1. Department of Dermatology, Andreas Syggros Hospital University of Athens, Athens, Greece

    Andreas D. Katsambas  & Clio Dessinioti  & 

  2. University of Rome “G. Marconi”, Rome, Italy

    Torello M. Lotti

  3. Centro Studi per la Ricerca Multidisciplinare Rigenerativa (CSRMR), Rome, Italy

    Torello M. Lotti

  4. Unit of Dermatology, University of Pisa, Pisa, Italy

    Angelo Massimiliano D’Erme

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Juhasz, I. (2015). Necrobiosis Lipoidica. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D’Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45139-7_66

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  • DOI: https://doi.org/10.1007/978-3-662-45139-7_66

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45138-0

  • Online ISBN: 978-3-662-45139-7

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