Skip to main content

Bullous Pemphigoid

  • Chapter
  • 205 Accesses

Abstract

Bullous pemphigoid (BP) is an acquired, subepidermal autoimmune blistering disease. Urticarial and figured erythemas are common prodromal eruptions, and subsequently, large tense blisters arise with a base of normal or erythematous skin. Diagnosis is made by biopsy and direct and indirect immunofluorescence. Topical steroids should be considered first-line treatment in localized or moderate BP, and systemic corticosteroids are rapidly inducing remission in the majority of patients. Other immunosuppressive agents used, among others, are azathioprine, cyclophosphamide, chlorambucil, and mycophenolate mofetil.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Further Reading

  • Bastuji-Garin S, et al. Risk factors for bullous pemphigoid in the elderly: a prospective case–control study. J Invest Dermatol. 2011;131:637–43.

    Article  CAS  Google Scholar 

  • Bouscrarat F, et al. Treatment of bullous pemphigoid with dapsone: retrospective study of thirty six cases. J Am Acad Dermatol. 1996;34:683–7.

    Article  Google Scholar 

  • Du-Thanh A, et al. Combined treatment with low-dose methotrexate and initial short- term superpotent topical steroids in bullous pemphigoid: an open, multicentre, retrospective study. Br J Dermatol. 2011;165:1337–43.

    Article  CAS  Google Scholar 

  • Engineer L, Ahmed AR. Role of intravenous immunoglobulin in the treatment of bullous pemphigoid. J Am Acad Dermatol. 2001;44:83–8.

    Article  CAS  Google Scholar 

  • Hideyuki U, Akihiko S, et al. What’s new in bullous pemphigoid. J Dermatol. 2010;37:194–204.

    Article  Google Scholar 

  • Huilgol SC, Black MM. Management of immunobullous diseases. I. Pemphigoid. Clin Exp Dermatol. 1995;20:189–201.

    Article  CAS  Google Scholar 

  • Kolbach DN, et al. Bullous pemphigoid successfully controlled by tetracycline and nicotinamide. Br J Dermatol. 1995;133:88–92.

    Article  CAS  Google Scholar 

  • Orvis AK, et al. Mycophenolate mofetil in dermatology. J Am Acad Dermatol. 2009;60(2):183–99.

    Article  Google Scholar 

  • Schmidt E, Obe K, Brocker EB, Zillikens D. Serum levels of autoantibodies to BP 180 correlates with disease activity in patients with bullous pemphigoid. Arch Dermatol. 2000;136:174–8.

    Article  CAS  Google Scholar 

  • Tee S, Yosipovitch G, et al. Prevention of glucocorticoid-induced osteoporosis in immunobullous diseases with alendronate: a randomized, double-blind, placebo- controlled study. Arch Dermatol. 2012;148:307–14.

    Article  CAS  Google Scholar 

  • Venning VA, et al. British Association of Dermatologists’ guidelines for the management of bullous pemphigoid 2012. Br J Dermatol. 2012;167:1200–14.

    Article  CAS  Google Scholar 

  • Yancey KB, Egan CA. Pemphigoid. Clinical, histology, immunopathology, and therapeutic considerations. JAMA. 2000;284(3):350–6.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Panagiotis G. Stavropoulos .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Stavropoulos, P.G., Remoudaki, E. (2015). Bullous Pemphigoid. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D’Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45139-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-45139-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45138-0

  • Online ISBN: 978-3-662-45139-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics