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Role of the Autonomic Nervous System in Ventricular Arrhythmias During Acute Myocardial Ischemia and Infarction

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Abstract

Significant advances have been made in recent years to elucidate the neural mechanisms involved in the genesis of cardiac arrhythmias during acute myocardial ischemia and infarction. The cellular and molecular processes whereby the sympathetic nervous system serves as a trigger for arrhythmia, and those responsible for the protective effect of vagus nerve activity, have been extensively characterized. Mounting evidence supports the importance of neural remodeling following myocardial infarction, which has provided valuable clues regarding factors that impact risk for sudden cardiac death. Promising nerve stimulation strategies including vagus nerve activation and spinal cord stimulation have progressed from animal testing to clinical trials.

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Abbreviations

ICD:

Implantable cardioverter defibrillator

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Harvard-Thorndike Electrophysiology Institute, 99 Brookline Avenue, RN-301, Boston, MA, 02215-3908, USA

    Richard L. Verrier PhD, FACC & Alex Y. Tan MD

Authors
  1. Richard L. Verrier PhD, FACC
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  2. Alex Y. Tan MD
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Corresponding author

Correspondence to Richard L. Verrier PhD, FACC .

Editor information

Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Riemer H.J.A. Slart

  2. Thorax center Cardiology, University Medical Center Groningen, Groningen, The Netherlands

    René A. Tio

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Philip H. Elsinga

  4. Nuklearmedizinische Klinik, Klinikum Rechts der Isar Technische Universität München, München, Germany

    Markus Schwaiger

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Verrier, R.L., Tan, A.Y. (2015). Role of the Autonomic Nervous System in Ventricular Arrhythmias During Acute Myocardial Ischemia and Infarction. In: Slart, R., Tio, R., Elsinga, P., Schwaiger, M. (eds) Autonomic Innervation of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45074-1_4

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  • DOI: https://doi.org/10.1007/978-3-662-45074-1_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45073-4

  • Online ISBN: 978-3-662-45074-1

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