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Imaging the Cardiac Automatic Nervous System in Diabetes Mellitus

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Autonomic Innervation of the Heart

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Abstract

Patients with diabetes mellitus are at an increased risk of silent myocardial infarction and are associated with poor outcome related to ventricular arrhythmias and sudden cardiac death. Although the cardiac sympathetic nervous system can be evaluated via the relatively simple and non-invasive assessment of heart rate variability, the evaluation with cardiac nuclear imaging using [123I]-metaiodobenzylguanidine ([123I]-MIBG) scintigraphy seems to be more sensitive. In addition, cardiac [123I]-MIBG-derived semiquantitative parameters are important predictors of outcome in patients with diabetes mellitus and heart failure.

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Abbreviations

CAD:

Coronary artery disease

CAN:

Cardiac autonomic neuropathy

DM:

Diabetes mellitus

ECG:

Electrocardiogram

H/M:

Heart/mediastinum

HF:

Heart failure

HRV:

Heart rate variability

LV:

Left ventricle

LVEF:

Left ventricular ejection fraction

NYHA:

New York Heart Association

PET:

Positron emission tomography

RR:

R-wave to R-wave interval

SPECT:

Single-photon emission computer tomography

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Author information

Authors and Affiliations

  1. Department of Cardiology, Leiden University Medical Center, University of Leiden, Leiden, The Netherlands

    Arthur J. H. A. Scholte MD, PhD

  2. Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Hein J. Verberne MD, PhD

Authors
  1. Arthur J. H. A. Scholte MD, PhD
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  2. Hein J. Verberne MD, PhD
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Corresponding author

Correspondence to Arthur J. H. A. Scholte MD, PhD .

Editor information

Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Riemer H.J.A. Slart

  2. Thorax center Cardiology, University Medical Center Groningen, Groningen, The Netherlands

    René A. Tio

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Philip H. Elsinga

  4. Nuklearmedizinische Klinik, Klinikum Rechts der Isar Technische Universität München, München, Germany

    Markus Schwaiger

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Scholte, A.J.H.A., Verberne, H.J. (2015). Imaging the Cardiac Automatic Nervous System in Diabetes Mellitus. In: Slart, R., Tio, R., Elsinga, P., Schwaiger, M. (eds) Autonomic Innervation of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45074-1_15

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  • DOI: https://doi.org/10.1007/978-3-662-45074-1_15

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45073-4

  • Online ISBN: 978-3-662-45074-1

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