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PET Imaging of Myocardial β-Adrenoceptors

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Autonomic Innervation of the Heart

Abstract

β-adrenoceptors are important in the regulation of heart function and have been studied extensively in recent decades. In vitro studies have shown downregulation of β-adrenoceptor density in heart failure and cardiac conditions that may lead to heart failure.

Novel methods have been developed to measure β-adrenoceptors in vivo with the use of positron emission tomography (PET). A PET study with the radioligand [11C]-CGP-12177 has shown promising results and measurements of β-adrenoceptor density with [11C]-CGP-12177 were shown to be reproducible and in agreement with in vitro studies. [11C]-CGP-12388 using a simpler method of radiochemical synthesis has been presented as an alternative. Also, transportable [18F]-labeled PET ligands are in development and applicable for more general use in PET centers lacking a cyclotron. Most PET studies with CGP radioligands were performed in the 1990s. The main limitation of [11C]-CGP-12177 and [11C]-CGP-12388, besides the troublesome production of the former, is the lack of subtype selectivity. Future perspectives may include the development of subtype-selective β-adrenergic receptor ligands to obtain more information about the pathophysiological role of the different subpopulations in vivo.

Using the full potential of PET, performance of regional measurements and longitudinal studies might add further knowledge to the pathophysiological role of the β-adrenoceptor in cardiac disease and the effect of interventions. This chapter will give an overview of the background of different β-adrenergic receptor types, their role in cardiac diseases, current PET imaging possibilities of the β-adrenergic receptor, and new developments in this field.

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Abbreviations

CRT:

Cardiac synchronization therapy

DCM:

Dilated cardiomyopathy

eNOS:

Endothelial isoform of NO synthase

ICD:

Implantable cardioverter defibrillator

IDC:

Idiopathic dilated cardiomyopathy

LV:

Left ventricle

LVEF:

Left ventricular ejection fraction

NO:

Nitric oxide

PET:

Positron emission tomography

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Authors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 30001, Groningen, 9700 RB, The Netherlands

    Riemer H. J. A. Slart MD, PhD & Philip H. Elsinga PhD

  2. Division Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Peter van der Meer MD, PhD, René A. Tio MD, PhD & Dirk J. van Veldhuisen MD, PhD

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  1. Riemer H. J. A. Slart MD, PhD
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  2. Peter van der Meer MD, PhD
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  3. René A. Tio MD, PhD
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  4. Dirk J. van Veldhuisen MD, PhD
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Correspondence to Riemer H. J. A. Slart MD, PhD .

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Editors and Affiliations

  1. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Riemer H.J.A. Slart

  2. Thorax center Cardiology, University Medical Center Groningen, Groningen, The Netherlands

    René A. Tio

  3. Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands

    Philip H. Elsinga

  4. Nuklearmedizinische Klinik, Klinikum Rechts der Isar Technische Universität München, München, Germany

    Markus Schwaiger

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Slart, R.H.J.A., van der Meer, P., Tio, R.A., van Veldhuisen, D.J., Elsinga, P.H. (2015). PET Imaging of Myocardial β-Adrenoceptors. In: Slart, R., Tio, R., Elsinga, P., Schwaiger, M. (eds) Autonomic Innervation of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45074-1_11

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  • Print ISBN: 978-3-662-45073-4

  • Online ISBN: 978-3-662-45074-1

  • eBook Packages: MedicineMedicine (R0)

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