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Embryologie und Teratologie

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Die Geburtshilfe

Part of the book series: Springer Reference Medizin ((SRM))

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Zusammenfassung

Im Verlauf der intrauterinen Entwicklung durchläuft die Frucht Stadien unterschiedlicher Empfindlichkeit gegenüber äußeren Einflüssen. Während sich die Reaktion auf schädigende Agenzien in den ersten beiden Wochen nach Konzeption weitgehend auf die Alternativen vollständige Heilung des Defekts oder Absterben beschränkt, können Einflüsse von Woche 3–8 nach Konzeption zu Störungen der Organdifferenzierung und damit zu Fehlbildungen führen.

In der Fetalperiode stehen Wachstums- und Funktionsstörungen durch exogene Noxen im Vordergrund.

Seit nach Einnahme von Thalidomid ca. 10.000 Kinder mit schweren Gliedmaßendefekten geboren wurden, herrscht bei pharmazeutischer Industrie, Ärzten und Patientinnen berechtigte Vorsicht gegenüber dem Einsatz von Arzneimitteln in der Schwangerschaft. Ein therapeutischer Nihilismus bei chronisch kranken Schwangeren kann jedoch zu einer dramatischen Verschlechterung der Grunderkrankung und damit zu einer erheblichen Gefährdung der fetalen Entwicklung führen.

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Authors and Affiliations

  1. Inst. für Reproduktionstoxikologie, Oberschwabenklinik, KH St. Elisabeth, Akad. Lehrkrankenhaus der Universität Ulm, Elisabethenstr. 17, 88212, Ravensburg, Deutschland

    Wolfgang E. Paulus

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  1. Wolfgang E. Paulus
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Correspondence to Wolfgang E. Paulus .

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Editors and Affiliations

  1. Frauenklinik, Universitätsklinikum, Bern, Switzerland

    Henning Schneider

  2. Frauenklinik, Medizinische Universität Wien, Wien, Austria

    Peter Husslein

  3. Frauenklinik u. Poliklinik, TU, Klinikum Rechts d. Isar, München, Germany

    Karl-Theo M. Schneider

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Paulus, W.E. (2016). Embryologie und Teratologie. In: Schneider, H., Husslein, P., Schneider, KT. (eds) Die Geburtshilfe. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45064-2_6

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  • DOI: https://doi.org/10.1007/978-3-662-45064-2_6

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