Zusammenfassung
Das Ersttrimesterscreening (ETS) zwischen 11 und 13 SSW – zunächst als Screeninguntersuchung auf Chromosomenstörungen konzipiert – umfasst heute weitere Screeninguntersuchungen auf typische Schwangerschaftskomplikationen. Damit wurde die klassische Schwangerenvorsorge revolutioniert, da mit der Etablierung des erweiterten ETS zahlreiche wichtige Fragen bereits in der Frühschwangerschaft beantwortet werden können und eine risikoadaptierte Schwangerenvorsorge möglich wurde.
Im Sinne einer primären Prävention kann so bereits vor klinischer Manifestation einer Schwangerschaftserkrankung das Risikokollektiv auf der Basis von anamnestischen Einflussfaktoren in Kombination mit biochemischen und biophysikalischen Parametern definiert werden, um effektive Maßnahmen zur Verhinderung der entsprechenden Komplikation treffen zu können. Wünschenswerte Konsequenz ist eine deutliche Absenkung der Prävalenz typischer Schwangerschaftskomplikationen, insbesondere der Präeklampsie und der Frühgeburt.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Akolekar R, Syngelaki A, Sarquis R, Zvanca M, Nicolaides KH (2011) Prediction of early, intermediate and late pre-eclampsia from maternal factors, biophysical and biochemical markers at 11–13 Weeks. Prenat Diagn 31(1):66–74
Akolekar R, Syngelaki A, Poon L, Wright D, Nicolaides KH (2013) Competing risks model in early screening for preeclampsia by biophysical and biochemical markers. Fetal Diagn Ther 33(1):8–15
Anderson UD, Olsson MG, Kristensen KH, Åkerström B, Hansson SR (2012) Review: biochemical markers to predict preeclampsia. Placenta 33:42–47
Bujold E, Roberge S, Lacasse Y, Bureau M, Audibert F, Marcoux S et al (2010) Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol 116(2 Pt 1):402–414
Greco E, Lange A, Ushakov F, Calvo JR, Nicolaides KH (2010) Prediction of spontaneous preterm delivery from endocervical length at 11 to 13 weeks. Prenat Diagn 31(1):84–89
Greco E, Gupta R, Syngelaki A, Poon LCY, Nicolaides KH (2012) First-trimester screening for spontaneous preterm delivery with maternal characteristics and cervical length. Fetal Diagn Ther 31(3):154–161
Kagan KO, Hoopmann M, Abele H, Wallwiener D (2012) Future developments in obstetrics. Gynakologe 45(9):684–689
Khalil A, Nicolaides KH (2013) How to record uterine artery doppler in the first trimester. Ultrasound Obstet Gynecol 42:478
Khalil A, Sodre D, Syngelaki A, Akolekar R, Nicolaides KH (2012) Maternal hemodynamics at 11–13 weeks of gestation in pregnancies delivering small for gestational age neonates. Fetal Diagn Ther 32(4):231–238
Kim YJ (2013) Pathogenesis and promising non-invasive markers for preeclampsia. Obstet Gynecol Sci Ultrasound 56(1):2
Meads CA, Cnossen JS, Meher S, Juarez-Garcia A, ter Riet G, Duley L et al (2008) Methods of prediction and prevention of pre-eclampsia: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technol Assess(Winchester, Engl) 12(6):iii–iv, 1–270
Myers JE, Kenny LC, McCowan L, Chan E, Dekker GA, Poston L et al (2013) Angiogenic factors combined with clinical risk factors to predict preterm pre-eclampsia in nulliparous women: a predictive test accuracy study. BJOG 120(10):1215–1223
Nicolaides KH (2011) A model for a new pyramid of prenatal care based on the 11 to 13 weeks’ assessment. Prenat Diagn 31(1):3–6
Onwudiwe N, Yu CKH, Poon LCY, Spiliopoulos I, Nicolaides KH (2008) Prediction of pre-eclampsia by a combination of maternal history, uterine artery doppler and mean arterial pressure. Ultrasound Obstet Gynecol 32(7):877–883
Papageorghiou AT, Yu CK, Bindra R, Pandis G, Nicolaides KHF, Medicine Foundation Second Trimester Screening Group et al (2001) Multicenter screening for pre-eclampsia and fetal growth restriction by transvaginal uterine artery doppler at 23 weeks of gestation. Ultrasound Obstet Gynecol 18(5):441–449
Papantoniou N, Bagiokos V, Agiannitopoulos K, Kolialexi A, Destouni A, Tounta G et al (2013) RASSF1A in maternal plasma as a molecular marker of preeclampsia. Prenat Diagn 33(7):682–687
Papastefanou I, Souka AP, Pilalis A, Eleftheriades M, Michalitsi V, Kassanos D (2011) First trimester prediction of small- and large-for-gestation neonates by an integrated model incorporating ultrasound parameters, biochemical indices and maternal characteristics. Acta Obstet Gynecol Scand 91(1):104–111
Plasencia W, Akolekar R, Dagklis T, Veduta A, Nicolaides KH (2011) Placental volume at 11–13 Weeks’ gestation in the prediction of birth weight percentile. Fetal Diagn Ther 30(1):23–28
Plasencia W, González Dávila E, Tetilla V, Padrón Pérez E, García Hernández JA, González González NL (2012) First-trimester screening for large-for-gestational-age infants. Ultrasound Obstet Gynecol 39(4):389–395
Poon LCY, Musci T, Song K, Syngelaki A, Nicolaides KH (2013a) Maternal plasma cell-free fetal and maternal DNA at 11-13 weeks' gestation: relation to fetal and maternal characteristics and pregnancy outcomes. Fetal Diagn Ther 33(4):215–223
Poon LCY, Syngelaki A, Akolekar R, Lai J, Nicolaides KH (2013b) Combined screening for preeclampsia and small for gestational age at 11–13 weeks. Fetal Diagn Ther 33(1):16–27
Retzke JD, Sonek JD, Lehmann J, Yazdi B, Kagan KO (2013) Comparison of three methods of cervical measurement in the first trimester: single-line, two-line, and tracing. Prenat Diagn 33(3):262–268
Roberge S, Nicolaides KH, Demers S, Villa P, Bujold E (2013) Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis. Ultrasound Obstet Gynecol Ultrasound 41(5):491–499
Roberts JM, Myatt L, Spong CY, Thom EA, Hauth JC, Leveno KJ et al (2010) Vitamins C and E to prevent complications of pregnancy-associated hypertension. NEJM 362(14):1282–1291
Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS, ACTS Study Group (2006) Vitamins C and E and the risks of preeclampsia and perinatal complications. NEJM 354(17):1796–1806
Velauthar L, Plana MN, Kalidindi M, Zamora J, Thilaganathan B, Illanes SE et al (2013) Uterine artery doppler in the first trimester as a risk factor for adverse pregnancy outcomes: a meta-analysis involving 55,974 women. Ultrasound Obstet Gynecol 43:500
Villa PM, Hämäläinen E, Mäki A, Räikkönen K, Pesonen A-K, Taipale P et al (2013) Vasoactive agents for the prediction of early- and late-onset preeclampsia in a high-risk cohort. BMC Pregnancy Childbirth 13:110
Wright D, Akolekar R, Syngelaki A, Poon LCY, Nicolaides KH (2012) A competing risks model in early screening for preeclampsia. Fetal Diagn Ther 32(3):171–178
Xiong X, Demianczuk NN, Saunders LD, Wang F-L, Fraser WD (2002) Impact of preeclampsia and gestational hypertension on birth weight by gestational age. Am J Epidemiol 155(3):203–209
Yu CKH, Papageorghiou AT, Parra M, Palma Dias R, Nicolaides KHF, Medicine Foundation Second Trimester Screening Group et al (2003) Randomized controlled trial using Low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery doppler at 23 weeks' gestation. Ultrasound Obstet Gynecol 22(3):233–239
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kagan, K.O., Kürzl, R. (2016). Risikostratifizierung im 1. Trimester. In: Schneider, H., Husslein, P., Schneider, KT. (eds) Die Geburtshilfe. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45064-2_11
Download citation
DOI: https://doi.org/10.1007/978-3-662-45064-2_11
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-45063-5
Online ISBN: 978-3-662-45064-2
eBook Packages: Medicine (German Language)