Hematopoietic Growth Factors

  • Anurag K. Agrawal
  • Jeffrey D. HordEmail author
Part of the Pediatric Oncology book series (PEDIATRICO)


Several recombinant human hematopoietic growth factors are approved and in clinical use but not all are approved for use in children with cancer. Here we review the evidence-based guidelines for neutrophil stimulating factors granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) as well as evidence regarding erythropoietins and platelet growth factors interleukin-11 (IL-11) and thrombopoietin (TPO)-receptor agonists. Among these hematopoietic growth factors, only G-CSF and GM-CSF are approved in children with cancer; we review the evidence regarding their use in different clinical scenarios as well as the appropriate timing and dose of therapy. Evidence regarding the current status of the other hematopoietic cytokines in regard to pediatric oncology patients is also reviewed.


Febrile Neutropenia Immune Thrombocytopenic Purpura Darbepoetin Alfa Hematopoietic Growth Factor Pediatric Oncology Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Hematology/OncologyChildren’s Hospital and Research Center OaklandOaklandUSA
  2. 2.Pediatric Hematology/OncologyChildren’s Hospital Medical Center of AkronAkronUSA

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