Effects of Hormone Replacement Therapy on Skin Viscoelasticity During Climacteric Aging

  • Gérald E. Piérard
  • Trinh Hermanns-Lê
  • Sébastien Piérard
  • Claudine Piérard-Franchimont


During perimenopause, the skin and a series of other organs become altered as prominent sex hormone declines. The natural climacteric is associated with a decline in functional properties of various tissues including viscoelasticity of the dermal connective tissue. There are many ways for assessing in vivo skin viscoelasticity, and the various procedures frequently measure distinct physical characteristics. The suction method has been selected by a majority of investigators looking at dermal functional changes during climacteric. Some women benefit from oral hormone replacement therapy (HRT) or transdermal estrogen therapy (TET) for controlling some unpleasant climacteric changes (osteoporosis, vasomotor instability, skin withering, dermal depletion in versican-hyaluronic acid, etc.). In particular, the hormonal repair exhibits some preventive and corrective effects in the functional decline of the dermal physical properties.


Hormone Replacement Therapy Stratum Corneum Menopausal Woman Papillary Dermis Suction Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Gérald E. Piérard
    • 1
  • Trinh Hermanns-Lê
    • 1
  • Sébastien Piérard
    • 2
  • Claudine Piérard-Franchimont
    • 1
  1. 1.Department of DermatopathologyUniversity Hospital of LiègeLiègeBelgium
  2. 2.Telecommunications and Imaging LaboratoryMontefiore Institute, Intelsig, University of LiègeLiègeBelgium

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