Abstract
Sex steroid hormones, estrogen, progesterone, and androgen play an important role in the gender-based pathophysiological differences observed in skin structure, function, and pathology. Age-related hormonal disturbances also have an impact on skin thickness, elasticity and moisture, skin aging, sebum production, and cellular immunity of the skin. Postmenopausal women experience drastic reduction in skin thickness, elasticity, and moisture as well as impaired wound healing. Marked menopausal changes are also observed in hair growth and sebum production. Estrogen and/or hormone replacement therapy do improve many of these pathophysiological changes. On the other hand, skin diseases such as melanoma seem to be progressive in the presence of estrogen. Thus, overall, age-related hormonal changes are responsible for many dermatologic alterations.
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References
McEwen BS, Alves SE. Estrogen actions in the central nervous system. Endocr Rev. 1999;20(3):279–307.
Burger HG, Dudley EC, Robertson DM, Dennerstein L. Hormonal changes in the menopause transition. Recent Prog Horm Res. 2002;57:257–75.
Birge SJ. HRT and cognition: what the evidence shows. OBG Manag. 2000;42:40–59.
Kanda N, Watanabe S. Regulatory roles of sex hormones in cutaneous biology and immunology. J Dermatol Sci. 2005;38(1):1–7.
Pelletier G, Ren L. Localization of sex steroid receptors in human skin. Histol Histopathol. 2004;19(2):629–36.
Zouboulis CC, Degitz K. Androgen action on human skin – from basic research to clinical significance. Exp Dermatol. 2004;13(4):5–10.
Farage MA, Miller KW, Zouboulis CC, Piérard GE, Maibach HI. Gender differences in skin aging and the changing profile of the sex hormones with age. J Steroids Horm Sci. 2012;3:109.doi:10.4172/2157-7536.1000109.
Haczynski J, Tarkowski R, Jarzabek K, Slomczynska M, Wolczynski S, Magoffin DA, et al. Human cultured skin fibroblasts express estrogen receptor alpha and beta. Int J Mol Med. 2002;10(2):149–53.
Zouboulis CC, Chen WC, Thornton MJ, Qin K, Rosenfield R. Sexual hormones in human skin. Horm Metab Res. 2007;39(2):85–95.
Fritsch M, Orfanos CE, Zouboulis CC. Sebocytes are the key regulators of androgen homeostasis in human skin. J Invest Dermatol. 2001;116(5):793–800.
Sawaya ME, Price VH. Different levels of 5alpha-reductase type I and II, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol. 1997;109(3):296–300.
Quatresooz P, Piérard-Franchimont C, Gaspard U, Piérard GE. Skin climacteric aging and hormone replacement therapy. J Cosmet Dermatol. 2006;5(1):3–8.
Dao HJ, Kazin RA. Gender differences in skin: a review of the literature. Gend Med. 2007;4(4):308–28.
Brincat M, Versi E, Moniz CF, Magos A, de Trafford J, Studd JW. Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet Gynecol. 1987;70(1):123–7.
Chen L, Dyson M, Rymer J, Bolton PA, Young SR. The use of high-frequency diagnostic ultrasound to investigate the effect of hormone replacement therapy on skin thickness. Skin Res Technol. 2001;7(2):95–7.
Baulieu EE, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci U S A. 2000;97(8):4279–84.
Jemec GB, Serup J. Scaling, dry skin and gender. A bioengineering study of dry skin. Acta Derm Venereol Suppl (Stockh). 1992;177:26–8.
Jackson SM, Williams ML, Feingold KR, Elias PM. Pathobiology of the stratum corneum. West J Med. 1993;158(3):279–85.
Südel KM, Venzke K, Mielke H, Breitenbach U, Mundt C, Jaspers S, et al. Novel aspects of intrinsic and extrinsic aging of human skin: beneficial effects of soy extract. Photochem Photobiol. 2005;81(3):581–7.
Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. Int J Dermatol. 1996;35(9):669–74.
Dunn LB, Damesyn M, Moore AA, Reuben DB, Greendale GA. Does estrogen prevent skin aging? Results from the First National Health and Nutrition Examination Survey (NHANES I). Arch Dermatol. 1997;133(3):339–42.
Grosman N. Study on the hyaluronic acid-protein complex, the molecular size of hyaluronic acid and the exchangeability of chloride in skin of mice before and after oestrogen treatment. Acta Pharmacol Toxicol (Copenh). 1973;33(3):201–8.
Pochi PE, Strauss JS, Downing DT. Age-related changes in sebaceous gland activity. J Invest Dermatol. 1979;73(1):108–11.
Paquet F, Piérard-Franchimont C, Fumal I, Goffin V, Paye M, Piérard GE. Sensitive skin at menopause; dew point and electrometric properties of the stratum corneum. Maturitas. 1998;28(3):221–7.
Piérard-Franchimont C, Letawe C, Goffin V, Piérard GE. Skin water-holding capacity and transdermal estrogen therapy for menopause: a pilot study. Maturitas. 1995;22(2):151–4.
Shah MG, Maibach HI. Estrogen and skin. An overview. Am J Clin Dermatol. 2001;2(3):143–50.
Henry F, Piérard-Franchimont C, Cauwenbergh G, Piérard GE. Age-related changes in facial skin contours and rheology. J Am Geriatr Soc. 1997;45(2):220–2.
Castelo-Branco C, Figueras F, Martínez de Osaba MJ, Vanrell JA. Facial wrinkling in postmenopausal women. Effects of smoking status and hormone replacement therapy. Maturitas. 1998;29(1):75–86.
Piérard-Franchimont C, Piérard GE. Postmenopausal aging of the sebaceous follicle: a comparison between women receiving hormone replacement therapy or not. Dermatology. 2002;204(1):17–22.
Shu YY, Maibach HI. Estrogen and skin: therapeutic options. Am J Clin Dermatol. 2011;12(5):297–311.
Makrantonaki E, Vogel K, Fimmel S, Oeff M, Seltmann H, Zouboulis CC. Interplay of IGF-I and 17beta-estradiol at age-specific levels in human sebocytes and fibroblasts in vitro. Exp Gerontol. 2008;43(10):939–46.
Grove GL. Physiologic changes in older skin. Clin Geriatr Med. 1989;5(1):115–25.
Holt DR, Kirk SJ, Regan MC, Hurson M, Lindblad WJ, Barbul A. Effect of age on wound healing in healthy human beings. Surgery. 1992;112(2):293–7; discussion 297–8.
Gilliver SC, Ashworth JJ, Ashcroft GS. The hormonal regulation of cutaneous wound healing. Clin Dermatol. 2007;25(1):56–62.
Gilliver SC, Ruckshanthi JPD, Atkinson SJ, Ashcroft GS. Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing. Lab Invest. 2007;87(9):871–81.
Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol. 1999;155(4):1137–46.
Ashcroft GS, Dodsworth J, van Boxtel E, Tarnuzzer RW, Horan MA, Schultz GS, et al. Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels. Nat Med. 1997;3(11):1209–15.
Hardman MJ, Waite A, Zeef L, Burow M, Nakayama T, Ashcroft GS. Macrophage migration inhibitory factor: a central regulator of wound healing. Am J Pathol. 2005;167(6):1561–74.
Farage MA, Miller KW, Berardesca E, Maibach H. Sex hormones, the skin and the immune system: interactions and implication for skin testing. Treat Strateg Dermatol. 2011;1(1):62–70.
Ackerman LS. Sex hormones and the genesis of autoimmunity. Arch Dermatol. 2006;142(3):371–6.
Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521–74.
Lahita RG. The role of sex hormones in systemic lupus erythematosus. Curr Opin Rheumatol. 1999;11(5):352–6.
Paus R, Cotsarelis G. The biology of hair follicles. N Engl J Med. 1999;341(7):491–7.
Rebora A. Pathogenesis of androgenetic alopecia. J Am Acad Dermatol. 2004;50(5):777–9.
Price VH. Androgenetic alopecia in women. J Investig Dermatol Symp Proc. 2003;8(1):24–7.
Hoffmann R, Niiyama S, Huth A, Kissling S, Happle R. 17alpha-estradiol induces aromatase activity in intact human anagen hair follicles ex vivo. Exp Dermatol. 2002;11(4):376–80.
Dinh QQ, Sinclair R. Female pattern hair loss: current treatment concepts. Clin Interv Aging. 2007;2(2):189–99.
Rittmaster RS. Hirsutism. Lancet. 1997;349(9046):191–5.
Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci. 2008;30(2):87–95.
Gupta A, Driscoll MS. Do hormones influence melanoma? Facts and controversies. Clin Dermatol. 2010;28(3):287–92.
Strouse JJ, Fears TR, Tucker MA, Wayne AS. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J Clin Oncol. 2005;23(21):4735–41.
de Giorgi V, Gori A, Grazzini M, Rossari S, Scarfì F, Corciova S, et al. Estrogens, estrogen receptors and melanoma. Expert Rev Anticancer Ther. 2011;11(5):739–47.
Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462–70.
Lavker RM. Cutaneous aging: chronologic versus photoaging. In: Gilchrest B, editor. Photodamage. Cambridge: Blackwell Science; 1995. p. 123–35.
Yaar M, Gilchrest BA. Aging of skin. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, editors. Fitpatrick’s dermatology in general medicine. New York: McGraw-Hill; 2003. p. 1386–98.
Sauerbronn AV, Fonseca AM, Bagnoli VR, Saldiva PH, Pinotti JA. The effects of systemic hormonal replacement therapy on the skin of postmenopausal women. Int J Gynaecol Obstet. 2000;68(1):35–41.
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Farage, M.A., Miller, K.W., Tzeghai, G.E., Berardesca, E., Maibach, H.I. (2015). Skin and Effect of Hormones and Menopause. In: Farage, M., Miller, K., Fugate Woods, N., Maibach, H. (eds) Skin, Mucosa and Menopause. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44080-3_7
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