Skip to main content

Infectious Diseases of the Small Intestine

  • Chapter
  • First Online:
Video Capsule Endoscopy

Abstract

Most infections that involve the small bowel are self-limiting, and endoscopic examination is rarely indicated in these cases. Suspicion of microbial enteritis can be confirmed by stool cultures and, if necessary, by detection of toxins or antigens. Persistent diarrhea and associated symptoms such as weight loss, fever, arthralgia, and neurologic deficits or findings such as anemia, inflammatory signs, eosinophilia, or signs of malabsorption warrant further investigation. Besides microscopic stool examination, the main tool for this purpose is flexible endoscopy with tissue sampling from the duodenum, terminal ileum, and colon. Video capsule endoscopy (VCE) can sometimes reveal changes in the jejunum or ileum, and it has a high negative predictive value to exclude such lesions. Its usefulness is limited by its inability to obtain biopsy specimens, but it can direct the type and approach of subsequent enteroscopy by providing information on localization and extent of the detected lesions.

The work was first published in 2006 by Springer Medizin Verlag Heidelberg with the following title: Atlas of Video Capsule Endoscopy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bentley SD, Maiwald M, Murphy LD, et al. Sequencing and analysis of the genome of the Whipple’s disease bacterium Tropheryma whipplei. Lancet. 2003;361:637–44.

    Article  CAS  PubMed  Google Scholar 

  2. Schneider T, Moos V, Loddenkemper C, et al. Whipple’s disease: new aspects of pathogenesis and treatment. Lancet Infect Dis. 2008;8:179–90.

    Article  CAS  PubMed  Google Scholar 

  3. Kolfenbach S, Monkemuller K, Rocken C, Malfertheiner P. Whipple’s disease: magnification endoscopy and histological characteristics. Endoscopy. 2008;40 Suppl 2:E112.

    Article  PubMed  Google Scholar 

  4. Fritscher-Ravens A, Swain CP, von Herbay A. Refractory Whipple’s disease with anaemia: first lessons from capsule endoscopy. Endoscopy. 2004;36:659–62.

    Article  CAS  PubMed  Google Scholar 

  5. Gay G, Roche JF, Delvaux M. Capsule endoscopy, transit times, and Whipple’s disease. Endoscopy. 2005;37:272–3.

    Article  CAS  PubMed  Google Scholar 

  6. Keane MG, Shariff M, Stocks J, et al. Imaging of the small bowel by capsule endoscopy in Whipple’s disease. Endoscopy. 2009;41 Suppl 2:E139.

    Article  PubMed  Google Scholar 

  7. Mateescu BR, Bengus A, Marinescu M, et al. First Pillcam Colon 2 capsule images of Whipple’s disease: case report and review of the literature. World J Gastrointest Endosc. 2012;4:575–8.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Bhat M, Laneuville P, Marliss EB, et al. Secondary intestinal lymphangiectasia due to multiple myeloma. Gastrointest Endosc. 2011;74:718–20.

    Article  PubMed  Google Scholar 

  9. Ratnaike RN. Whipple’s disease. Postgrad Med J. 2000;76:760–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Dzirlo L, Blaha B, Muller C, et al. Capsule endoscopic appearance of the small-intestinal mucosa in Whipple’s disease and the changes that occur during antibiotic therapy. Endoscopy. 2007;39 Suppl 1:E207–8.

    Article  PubMed  Google Scholar 

  11. Lagier JC, Fenollar F, Lepidi H, Raoult D. Failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic Whipple’s disease. J Antimicrob Chemother. 2010;65:2005–12.

    Article  CAS  PubMed  Google Scholar 

  12. Pantongrag-Brown L, Nelson AM, Brown AE, et al. Gastrointestinal manifestations of acquired immunodeficiency syndrome: radiologic-pathologic correlation. Radiographics. 1995;15:1155–78.

    Article  CAS  PubMed  Google Scholar 

  13. Aldeman NL, Guimaraes LM, Cabral MM. Atypical duodenal mycobacteriosis in a patient with AIDS. Braz J Infect Dis. 2012;16:209–10.

    Article  PubMed  Google Scholar 

  14. Escapa VM, Beltran VP, Viudez LA, et al. Intestinal involvement by Micobacterium genavense in an immunodepressed patient. Gastrointest Endosc. 2010;72:1108–10.

    Article  PubMed  Google Scholar 

  15. Collado C, Stirnemann J, Ganne N, et al. Gastrointestinal tuberculosis: 17 cases collected in 4 hospitals in the northeastern suburb of Paris. Gastroenterol Clin Biol. 2005;29:419–24.

    Article  PubMed  Google Scholar 

  16. Radzi M, Rihan N, Vijayalakshmi N, Pani SP. Diagnostic challenge of gastrointestinal tuberculosis: a report of 34 cases and an overview of the literature. Southeast Asian J Trop Med Public Health. 2009;40:505–10.

    PubMed  Google Scholar 

  17. Cordova J, Shiloh R, Gilman RH, et al. Evaluation of molecular tools for detection and drug susceptibility testing of Mycobacterium tuberculosis in stool specimens from patients with pulmonary tuberculosis. J Clin Microbiol. 2010;48:1820–6.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Loureiro AI, Pinto CS, Oliveira AI, et al. Ulcerated lesion of the cecum as a form of presentation of gastrointestinal tuberculosis. [Article in Portuguese]. Acta Med Port. 2011;24:371–4.

    PubMed  Google Scholar 

  19. Kim ES, Keum B, Jeen YT, Chun HJ. Isolated small bowel tuberculosis with stricture diagnosed by capsule endoscopy. Dig Liver Dis. 2012;44:84.

    Article  PubMed  Google Scholar 

  20. Lee CW, Chang WH, Shih SC, et al. Gastrointestinal tract pseudo-obstruction or obstruction due to Mycobacterium tuberculosis breakthrough. Int J Infect Dis. 2009;13:e185–7.

    Article  PubMed  Google Scholar 

  21. Pulimood AB, Amarapurkar DN, Ghoshal U, et al. Differentiation of Crohn’s disease from intestinal tuberculosis in India in 2010. World J Gastroenterol. 2011;17:433–43.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Ramchandani M, Reddy DN, Gupta R, et al. Diagnostic yield and therapeutic impact of single-balloon enteroscopy: series of 106 cases. J Gastroenterol Hepatol. 2009;24:1631–8.

    Article  PubMed  Google Scholar 

  23. Reddy DN, Sriram PV, Rao GV, Reddy DB. Capsule endoscopy appearances of small-bowel tuberculosis. Endoscopy. 2003;35:99.

    Article  PubMed  Google Scholar 

  24. Chang DK, Kim JJ, Choi H, et al. Double balloon endoscopy in small intestinal Crohn’s disease and other inflammatory diseases such as cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). Gastrointest Endosc. 2007;66:S96–8.

    Article  PubMed  Google Scholar 

  25. Matsumoto T, Kudo T, Esaki M, et al. Prevalence of non-steroidal anti-inflammatory drug-induced enteropathy determined by double-balloon endoscopy: a Japanese multicenter study. Scand J Gastroenterol. 2008;43:490–6.

    Article  CAS  PubMed  Google Scholar 

  26. Park SH, Yang SK, Yang DH, et al. Prospective randomized trial of six-month versus nine-month therapy for intestinal tuberculosis. Antimicrob Agents Chemother. 2009;53:4167–71.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Tsinganou E, Gebbers JO. Human intestinal spirochetosis–a review. Ger Med Sci. 2010;8:Doc01. doi:10.3205/000090.

    PubMed Central  PubMed  Google Scholar 

  28. Lozano C, Arellano L, Yaquich P. Human intestinal spirochetosis: clinical series and literature review. [Article in Spanish]. Rev Chilena Infectol. 2012;29:449–52.

    Article  PubMed  Google Scholar 

  29. Koulaouzidis A, Campbell S, Ahmed S, et al. Colonic spirochetosis associated with dermatomyositis. Endoscopy. 2007;39 Suppl 1:E30–1.

    Article  PubMed  Google Scholar 

  30. Al-Saleem T, Al-Mondhiry H. Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. Blood. 2005;105:2274–80.

    Article  CAS  PubMed  Google Scholar 

  31. Mesnard B, De VB, Maunoury V, Lecuit M. Immunoproliferative small intestinal disease associated with Campylobacter jejuni. Dig Liver Dis. 2012;44:799–800.

    Article  PubMed  Google Scholar 

  32. Mönkemüller K, Safatle-Ribeiro AV, Olano C, Fry LC. Unusual findings in the small bowel. VJGIEN. 2013;1:286–8. http://dx.doi.org/10.1016/S2212-0971(13)70125-0.

    Google Scholar 

  33. Ersoy O, Akin E, Demirezer A, Atalay R, Buyukasik S. Capsule-endoscopic findings in immunoproliferative small-intestinal disease. Endoscopy. 2012;44(Suppl 2 UCTN):E61–2.

    PubMed  Google Scholar 

  34. Safatle-Ribeiro AV, Iriya K, Couto DS, et al. Secondary lymphangiectasia of the small bowel: utility of double balloon enteroscopy for diagnosis and management. Dig Dis. 2008;26:383–6.

    Article  PubMed  Google Scholar 

  35. Cha JM, Lee JI, Choe JW, et al. Cytomegalovirus enteritis causing ileal perforation in an elderly immunocompetent individual. Yonsei Med J. 2010;51:279–83.

    Article  PubMed Central  PubMed  Google Scholar 

  36. Kalaitzis J, Basioukas P, Karzi E, et al. Small-bowel necrosis complicating a cytomegalovirus-induced superior mesenteric vein thrombosis in an immunocompetent patient: a case report. J Med Case Rep. 2012;6:118.

    Article  PubMed Central  PubMed  Google Scholar 

  37. Papadimitriou G, Koukoulaki M, Vardas K, et al. Small bowel obstruction caused by inflammatory cytomegalovirus tumor in a renal transplant recipient: report of a rare case and review of the literature. Transplant Infect Dis. 2012;14:E111–5.

    Article  CAS  Google Scholar 

  38. Sakai E, Endo H, Tokoro C, et al. Cytomegalovirus-induced small-bowel bleeding detected by capsule endoscopy. Gastrointest Endosc. 2011;73:1058–60.

    Article  PubMed  Google Scholar 

  39. Kakugawa Y, Kim SW, Takizawa K, et al. Small intestinal CMV disease detected by capsule endoscopy after allogeneic hematopoietic SCT. Bone Marrow Transplant. 2008;42:283–4.

    Article  CAS  PubMed  Google Scholar 

  40. Jha AK, Uppal B, Chadha S, et al. Clinical and microbiological profile of HIV/AIDS cases with diarrhea in North India. J Pathog. 2012;2012:971958.

    PubMed Central  PubMed  Google Scholar 

  41. Nawabi DH, Ffolkes L, O’Bichere A. Cryptococcal small-bowel obstruction in an HIV-positive patient. J R Soc Med. 2005;98:513–4.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  42. Tzimas D, Wan D. Small bowel perforation in a patient with AIDS. Diagnosis: small bowel infection with Cryptococcus neoformans. Gastroenterology. 2011;140:1882. 2150.

    Article  PubMed  Google Scholar 

  43. Marco-Lattur MD, Payeras A, Campins AA, et al. Intestinal lymphangiectasia: an undescribed cause of malabsorption and incomplete immunological recovery in HIV-infected patients. Enferm Infecc Microbiol Clin. 2011;29:117–20.

    Article  PubMed  Google Scholar 

  44. Cello JP, Day LW. Idiopathic AIDS enteropathy and treatment of gastrointestinal opportunistic pathogens. Gastroenterology. 2009;136:1952–65.

    Article  CAS  PubMed  Google Scholar 

  45. Venkataramani A, Behling CA, Lyche KD. Sclerosing mesenteritis: an unusual cause of abdominal pain in an HIV-positive patient. Am J Gastroenterol. 1997;92:1059–60.

    CAS  PubMed  Google Scholar 

  46. Fonseca LC, Mignone C. Paracoccidioidomycosis of the small intestine. Radiologic and anatomo clinical aspects of 125 cases. Rev Hosp Clin Fac Med Sao Paulo. 1976;31:199–207.

    CAS  PubMed  Google Scholar 

  47. Lemos LB, Baliga M, Guo M. Blastomycosis: the great pretender can also be an opportunist. Initial clinical diagnosis and underlying diseases in 123 patients. Ann Diagn Pathol. 2002;6:194–203.

    Article  PubMed  Google Scholar 

  48. Avritchir Y, Perroni AA. Radiological manifestations of small intestinal South American Blastomycosis. Radiology. 1978;127:607–9.

    Article  CAS  PubMed  Google Scholar 

  49. Sawatzki M, Peter S, Hess C. Therapy-resistant diarrhea due to Giardia lamblia in a patient with common variable immunodeficiency disease. Digestion. 2007;75:101–2.

    Article  CAS  PubMed  Google Scholar 

  50. Rossignol JF. Cryptosporidium and Giardia: treatment options and prospects for new drugs. Exp Parasitol. 2010;124:45–53.

    Article  PubMed  Google Scholar 

  51. Perez-Roldan F, Mate-Valdezate A, Villafanez-Garcia MC, et al. Nodular lymphoid hyperplasia by Giardia lamblia. Endoscopy. 2008;40 Suppl 2:E116–7.

    Article  PubMed  Google Scholar 

  52. Sriram PV, Rao GV, Reddy DN. Wireless capsule endoscopy: experience in a tropical country. J Gastroenterol Hepatol. 2004;19:63–7.

    Article  CAS  PubMed  Google Scholar 

  53. Croese J, Speare R. Intestinal allergy expels hookworms: seeing is believing. Trends Parasitol. 2006;22:547–50.

    Article  CAS  PubMed  Google Scholar 

  54. De Simone P, Feron P, Loi P, et al. Acute intestinal bleeding due to Taenia solium infection. Chir Ital. 2004;56:151–6.

    PubMed  Google Scholar 

  55. Karanikas ID, Sakellaridis TE, Alexiou CP, et al. Taenia saginata: a rare cause of bowel obstruction. Trans R Soc Trop Med Hyg. 2007;101:527–8.

    Article  CAS  PubMed  Google Scholar 

  56. Floro L, Pak G, Sreter L, Tulassay Z. Wireless capsule endoscopy in the diagnosis of helminthiasis. Gastrointest Endosc. 2007;65:1078. discussion 9.

    Article  PubMed  Google Scholar 

  57. Mittal S, Sagi SV, Hawari R. Strongyloidiasis: endoscopic diagnosis. Clin Gastroenterol Hepatol. 2009;7:e8.

    Article  PubMed  Google Scholar 

  58. Somani SK, Goyal R, Awasthi G. Duodenal mucosal nodularity in Strongyloides stercoralis infection. Trop Gastroenterol. 2009;30:47–8.

    PubMed  Google Scholar 

  59. Thompson BF, Fry LC, Wells CD, et al. The spectrum of GI strongyloidiasis: an endoscopic-pathologic study. Gastrointest Endosc. 2004;59:906–10.

    Article  PubMed  Google Scholar 

  60. Hosoe N, Imaeda H, Okamoto S, et al. A case of beef tapeworm (Taenia saginata) infection observed by using video capsule endoscopy and radiography (with videos). Gastrointest Endosc. 2011;74:690–1.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Peter Baltes .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Baltes, P., Safatle-Ribeiro, A., Keuchel, M., Reddy, D.N. (2014). Infectious Diseases of the Small Intestine. In: Keuchel, M., Hagenmüller, F., Tajiri, H. (eds) Video Capsule Endoscopy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44062-9_28

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-44062-9_28

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-44061-2

  • Online ISBN: 978-3-662-44062-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics